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ICPT

Intercept

$116.67

-2.15 (-1.81%)

07:12
06/12/17
06/12
07:12
06/12/17
07:12

Intercept announces new data analysis from FLINT trial of OCA

Intercept Pharmaceuticals announced a retrospective analysis of the Phase 2 FLINT trial in patients who had a diagnosis of nonalcoholic steatohepatitis, or NASH, and type 2 diabetes. The poster entitled "Improvements in Liver Histology with Obeticholic Acid in Patients with Nonalcoholic Steatohepatitis and Type 2 Diabetes Mellitus" was presented at the American Diabetes Association's 77th Scientific Sessions in San Diego, California. Obeticholic acid, or OCA, is an investigational therapy for the treatment of NASH. Both type 2 diabetes and advanced fibrosis are associated with lower transplant-free survival in patients with NASH. In FLINT, 149 NASH patients had type 2 diabetes and, within this population, 45% had advanced bridging fibrosis. In a retrospective analysis of FLINT patients with a diagnosis of NASH and type 2 diabetes at baseline, a greater percentage of OCA-treated patients achieved the primary endpoint of the trial, a greater than or equal to2-point improvement in NAFLD activity score, or NAS, without worsening of fibrosis, at week 72 as compared to placebo. More than twice as many OCA-treated patients with fibrosis experienced greater than or equal to1 stage of fibrosis improvement as compared to patients in the placebo group. This benefit was observed for every fibrosis stage. OCA treatment resulted in a mean 3.3 kg reduction in body weight from baseline compared to a 0.3 kg increase in the placebo group.

  • 13

    Jun

ICPT Intercept
$116.67

-2.15 (-1.81%)

02/23/17
FBCO
02/23/17
NO CHANGE
FBCO
Intercept shares defended at Credit Suisse
02/24/17
BMOC
02/24/17
NO CHANGE
BMOC
Intercept price target raised to $221 from $198 at BMO Capital
BMO Capital analyst M. Ian Somaiya raised his price target on Intercept as he believes that updated launch metrics on the company's Ocaliva drug suggest that 2017 sales of the product will exceed expectations. He keeps an Outperform rating on the stock.
02/28/17
SBSH
02/28/17
NO CHANGE
Target $240
SBSH
Buy
Intercept price target lowered to $240 from $275 at Citi
Citi analyst Joel Beatty lowered his price target for Intercept Pharmaceuticals to $240 citing less upside potential over the next year with REGENERATE trial results still likely at least two years away. The analyst reiterates a Buy rating on Intercept, however, saying investors should get more comfortable that NASH is a "sizeable drug opportunity" as development of OCA and other NASH drugs advance.
05/05/17
LDLW
05/05/17
UPGRADE
LDLW
Hold
Intercept upgraded to Hold from Sell at Laidlaw

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