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EXEL

Exelixis

$19.25

-0.47 (-2.38%)

08:06
06/12/17
06/12
08:06
06/12/17
08:06

Exelixis initiates phase 1b trial of cabozanitinib, atezolizumab combination

Exelixis announced the initiation of the dose-escalation stage of a phase 1b trial of cabozantinib in combination with atezolizumab in patients with locally advanced or metastatic urothelial carcinoma or renal cell carcinoma. The primary objective is to determine the optimal dose and schedule of daily oral administration of cabozantinib when given in combination with atezolizumab to inform the trial's subsequent expansion stage. This multicenter phase 1b, open-label study is divided in two parts: a dose-escalation phase and an expansion cohort phase. The dose-escalation phase will enroll 9 to 36 patients with inoperable, locally advanced, metastatic or recurrent UC after prior platinum-based therapy or RCC with or without prior systemic therapy. The starting dose of cabozantinib will be 40 mg daily and may be increased to 60 mg daily or decreased to 20 mg daily. All patients will receive the standard atezolizumab dosing regimen. The secondary objectives of the dose-escalation stage are to evaluate the plasma pharmacokinetics of daily oral administration of cabozantinib when given in combination with atezolizumab and to assess safety of the combination therapy through the evaluation of incidence and severity of adverse events, including immune-related adverse events. Exploratory endpoints include the correlation of clinical outcome with immune cell, tumor cell and blood biomarker analyses. Once the recommended dose and schedule are determined, the trial will enroll four expansion cohorts, each with up to 30 patients, for a total of up to 120 patients with advanced or metastatic UC or RCC. The primary objective in the expansion stage of the trial is to determine the objective response rate in each cohort.

  • 13

    Jun

EXEL Exelixis
$19.25

-0.47 (-2.38%)

03/31/17
NEED
03/31/17
INITIATION
Target $28
NEED
Exelixis initiated with a Buy at Needham
Needham analyst Chad Messer initiated Exelixis with a Buy and a $28 price target.
03/16/17
03/16/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Snap (SNAP) initiated with a Sell at MoffettNathanson. 2. Alliant Energy (LNT) initiated with a Neutral at UBS. 3. Carbonite (CARB) initiated with a Buy at Craig-Hallum. 4. Dermira (DERM) initiated with an Underperform at Raymond James. 5. Exelixis (EXEL) initiated with a Perform at Oppenheimer. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
03/15/17
OPCO
03/15/17
INITIATION
OPCO
Perform
Exelixis initiated with a Perform at Oppenheimer
Oppenheimer analyst Leah Rush Cann initiated Exelixis with a Perform rating, expecting earnings will turn positive during 2017.
02/28/17
02/28/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Workday (WDAY) downgraded to Sell from Neutral at Citi and to Hold from Buy at Evercore ISI. 2. Exelixis (EXEL) downgraded to Hold from Buy at Stifel with analyst Stephen Willey citing valuation. 3. Teva (TEVA) downgraded to Hold from Buy at Argus. 4. Cabot Oil & Gas (COG) downgraded to Market Perform from Outperform at Bernstein. 5. HP Enterprise (HPE) downgraded to Hold from Buy at Argus. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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CALD

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FHN

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KSBI

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UPS

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  • 28

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