Breaking News Instant updates and real-time market news.

EXEL

Exelixis

$19.25

-0.47 (-2.38%)

08:06
06/12/17
06/12
08:06
06/12/17
08:06

Exelixis initiates phase 1b trial of cabozanitinib, atezolizumab combination

Exelixis announced the initiation of the dose-escalation stage of a phase 1b trial of cabozantinib in combination with atezolizumab in patients with locally advanced or metastatic urothelial carcinoma or renal cell carcinoma. The primary objective is to determine the optimal dose and schedule of daily oral administration of cabozantinib when given in combination with atezolizumab to inform the trial's subsequent expansion stage. This multicenter phase 1b, open-label study is divided in two parts: a dose-escalation phase and an expansion cohort phase. The dose-escalation phase will enroll 9 to 36 patients with inoperable, locally advanced, metastatic or recurrent UC after prior platinum-based therapy or RCC with or without prior systemic therapy. The starting dose of cabozantinib will be 40 mg daily and may be increased to 60 mg daily or decreased to 20 mg daily. All patients will receive the standard atezolizumab dosing regimen. The secondary objectives of the dose-escalation stage are to evaluate the plasma pharmacokinetics of daily oral administration of cabozantinib when given in combination with atezolizumab and to assess safety of the combination therapy through the evaluation of incidence and severity of adverse events, including immune-related adverse events. Exploratory endpoints include the correlation of clinical outcome with immune cell, tumor cell and blood biomarker analyses. Once the recommended dose and schedule are determined, the trial will enroll four expansion cohorts, each with up to 30 patients, for a total of up to 120 patients with advanced or metastatic UC or RCC. The primary objective in the expansion stage of the trial is to determine the objective response rate in each cohort.

  • 13

    Jun

EXEL Exelixis
$19.25

-0.47 (-2.38%)

03/31/17
NEED
03/31/17
INITIATION
Target $28
NEED
Exelixis initiated with a Buy at Needham
Needham analyst Chad Messer initiated Exelixis with a Buy and a $28 price target.
03/16/17
03/16/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Snap (SNAP) initiated with a Sell at MoffettNathanson. 2. Alliant Energy (LNT) initiated with a Neutral at UBS. 3. Carbonite (CARB) initiated with a Buy at Craig-Hallum. 4. Dermira (DERM) initiated with an Underperform at Raymond James. 5. Exelixis (EXEL) initiated with a Perform at Oppenheimer. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
03/15/17
OPCO
03/15/17
INITIATION
OPCO
Perform
Exelixis initiated with a Perform at Oppenheimer
Oppenheimer analyst Leah Rush Cann initiated Exelixis with a Perform rating, expecting earnings will turn positive during 2017.
02/28/17
02/28/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Workday (WDAY) downgraded to Sell from Neutral at Citi and to Hold from Buy at Evercore ISI. 2. Exelixis (EXEL) downgraded to Hold from Buy at Stifel with analyst Stephen Willey citing valuation. 3. Teva (TEVA) downgraded to Hold from Buy at Argus. 4. Cabot Oil & Gas (COG) downgraded to Market Perform from Outperform at Bernstein. 5. HP Enterprise (HPE) downgraded to Hold from Buy at Argus. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

UUUU

Energy Fuels

$1.65

-0.06 (-3.51%)

06:10
08/23/17
08/23
06:10
08/23/17
06:10
Hot Stocks
Energy Fuels updates estimate for uranium and copper resources at Canyon Mine »

Energy Fuels announced…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

WMT

Wal-Mart

$80.02

0.31 (0.39%)

, GOOG

Alphabet

$924.69

18.03 (1.99%)

06:09
08/23/17
08/23
06:09
08/23/17
06:09
Hot Stocks
Wal-Mart to offer hundreds of thousands of items for voice shopping with Google »

Marc Lore, President and…

WMT

Wal-Mart

$80.02

0.31 (0.39%)

GOOG

Alphabet

$924.69

18.03 (1.99%)

GOOGL

Alphabet Class A

$940.40

19.53 (2.12%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Aug

  • 16

    Nov

  • 20

    Feb

LOW

Lowe's

$75.82

1.97 (2.67%)

06:07
08/23/17
08/23
06:07
08/23/17
06:07
Hot Stocks
Lowe's reports Q2 SSS up 4.5% »

Comparable sales for the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Aug

  • 21

    Nov

WMT

Wal-Mart

$80.02

0.31 (0.39%)

, GOOG

Alphabet

$924.69

18.03 (1.99%)

06:07
08/23/17
08/23
06:07
08/23/17
06:07
Hot Stocks
Wal-Mart, Google partner on voice-based shopping »

Sridhar Ramaswamy, SVP,…

WMT

Wal-Mart

$80.02

0.31 (0.39%)

GOOG

Alphabet

$924.69

18.03 (1.99%)

GOOGL

Alphabet Class A

$940.40

19.53 (2.12%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Aug

  • 16

    Nov

  • 20

    Feb

LOW

Lowe's

$75.82

1.97 (2.67%)

06:04
08/23/17
08/23
06:04
08/23/17
06:04
Hot Stocks
Lowe's CEO says 'pleased with our improved comparable sales performance' »

"We are pleased with…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Aug

  • 21

    Nov

LOW

Lowe's

$75.82

1.97 (2.67%)

06:03
08/23/17
08/23
06:03
08/23/17
06:03
Earnings
Lowe's revises FY17 EPS view to $4.20-$4.30 from about $4.30, consensus $4.62 »

Backs FY17 revenue growth…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Aug

  • 21

    Nov

GOOG

Alphabet

$924.69

18.03 (1.99%)

, GOOGL

Alphabet Class A

$940.40

19.53 (2.12%)

06:02
08/23/17
08/23
06:02
08/23/17
06:02
Periodicals
Google to announce specs for Titan security chip on Thursday, Reuters reports »

Google (GOOG) is expected…

GOOG

Alphabet

$924.69

18.03 (1.99%)

GOOGL

Alphabet Class A

$940.40

19.53 (2.12%)

AMZN

Amazon.com

$966.90

13.61 (1.43%)

MSFT

Microsoft

$73.16

1.01 (1.40%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Aug

  • 24

    Aug

  • 24

    Aug

  • 05

    Sep

LOW

Lowe's

$75.82

1.97 (2.67%)

06:00
08/23/17
08/23
06:00
08/23/17
06:00
Earnings
Lowe's reports Q2 adjusted EPS $1.57, consensus $1.61 »

Reports Q2 revenue…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Aug

  • 21

    Nov

SPX

S&P 500

06:00
08/23/17
08/23
06:00
08/23/17
06:00
Technical Analysis
S&P 500: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MSFT

Microsoft

$73.16

1.01 (1.40%)

05:59
08/23/17
08/23
05:59
08/23/17
05:59
Hot Stocks
Microsoft unveils Project Brainwave for real-time AI »

Microsoft engineer Doug…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 05

    Sep

GDX

Market Vector Gold Miners

$23.09

-0.22 (-0.94%)

05:57
08/23/17
08/23
05:57
08/23/17
05:57
Technical Analysis
Market Vector Gold Miners: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

GLD

SPDR Gold Trust

$122.21

-0.55 (-0.45%)

05:57
08/23/17
08/23
05:57
08/23/17
05:57
Technical Analysis
SPDR Gold Trust: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MRAM

Everspin Technologies

$15.22

0.3 (2.01%)

05:57
08/23/17
08/23
05:57
08/23/17
05:57
Hot Stocks
Everspin Technologies names Kevin Conley as CEO, effective September 1 »

Everspin Technologies…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 06

    Sep

NUGT

Direxion Gold Miners Bull

$32.79

-0.86 (-2.56%)

05:57
08/23/17
08/23
05:57
08/23/17
05:57
Technical Analysis
Direxion Gold Miners Bull: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

JNUG

Direxion Daily Jr Gld Mnrs Bull 3X Shrs

$18.22

-0.58 (-3.09%)

05:56
08/23/17
08/23
05:56
08/23/17
05:56
Technical Analysis
Direxion Daily Jr Gld Mnrs Bull 3X Shrs: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

DUST

Direxion Daily Gold Miners Bear 3X ETF

$26.31

0.61 (2.37%)

05:56
08/23/17
08/23
05:56
08/23/17
05:56
Technical Analysis
Direxion Daily Gold Miners Bear 3X ETF: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

JDST

Direxion Daily Junior Gold Miners Index Bear 3x Shares

$60.10

1.74 (2.98%)

05:56
08/23/17
08/23
05:56
08/23/17
05:56
Technical Analysis
Direxion Daily Junior Gold Miners Index Bear 3x Shares: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

VXX

iPath S&P 500 VIX Short-Term Futures

$47.36

-3.72 (-7.28%)

05:55
08/23/17
08/23
05:55
08/23/17
05:55
Technical Analysis
iPath S&P 500 VIX Short-Term Futures: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

XIV

VelocityShares Daily Inverse VIX Short-Term ETN

$82.37

5.27 (6.84%)

05:55
08/23/17
08/23
05:55
08/23/17
05:55
Technical Analysis
VelocityShares Daily Inverse VIX Short-Term ETN: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

TVIX

VelocityShares Daily 2x VIX Short-Term ETN

$16.79

-2.75 (-14.07%)

05:54
08/23/17
08/23
05:54
08/23/17
05:54
Technical Analysis
VelocityShares Daily 2x VIX Short-Term ETN: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SVXY

ProShares Short VIX Short-Term Futures

$78.87

5.4 (7.35%)

05:54
08/23/17
08/23
05:54
08/23/17
05:54
Technical Analysis
ProShares Short VIX Short-Term Futures: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

USO

United States Oil Fund

$9.77

0.06 (0.62%)

05:54
08/23/17
08/23
05:54
08/23/17
05:54
Technical Analysis
United States Oil Fund: Pivot points, pivot low broken »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

XOP

SPDR Oil Exploration and Production Fund

$29.34

0.25 (0.86%)

05:53
08/23/17
08/23
05:53
08/23/17
05:53
Technical Analysis
SPDR Oil Exploration and Production Fund: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

DGAZ

VelocityShares 3x Inv Natural Gas ETN

$25.16

0.58 (2.36%)

05:52
08/23/17
08/23
05:52
08/23/17
05:52
Technical Analysis
VelocityShares 3x Inv Natural Gas ETN: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

UGAZ

VelocityShares 3x Long Natural Gas ETN

$12.14

-0.29 (-2.33%)

05:52
08/23/17
08/23
05:52
08/23/17
05:52
Technical Analysis
VelocityShares 3x Long Natural Gas ETN: Pivot points »

The following are the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.