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XLRN

Acceleron

$28.23

-0.81 (-2.79%)

16:32
06/12/17
06/12
16:32
06/12/17
16:32

Acceleron says DART Phase 2 study plus axitinib did not achieve primary endpoint

Acceleron Pharma announced that the DART Phase 2 study of dalantercept plus axitinib did not achieve its primary endpoint in advanced renal cell carcinoma. The primary efficacy endpoint of the study was to demonstrate a statistically significant increase in progression-free survival for treatment of dalantercept plus axitinib versus placebo plus axitinib in advanced RCC patients. The DART study enrolled 131 patients with advanced RCC. The efficacy data are based on the All-Treated Set which is defined as all randomized patients who received any study drug as of the database cutoff. In the ATS, 58 patients were randomized to dalantercept plus axitinib and 61 patients were randomized to placebo plus axitinib. "We designed a robust Phase 2 study to evaluate the efficacy of dalantercept in combination with anti-VEGF therapy in advanced renal cell carcinoma patients whose disease has progressed on prior anti-VEGF therapy. We are disappointed by the results given the need for new agents that improve outcomes for patients with advanced RCC. We would like to thank the patients, caregivers, investigators, and our team who made the DART study possible," said Habib Dable, President and Chief Executive Officer of Acceleron. "Based on the lack of efficacy, we are discontinuing the development of dalantercept. We remain focused on the development of luspatercept across multiple Phase 3 and Phase 2 studies and ACE-083 across two neuromuscular diseases, and will continue to pursue additional candidates in areas of high unmet medical need."

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XLRN Acceleron
$28.23

-0.81 (-2.79%)

03/23/17
FBRC
03/23/17
NO CHANGE
FBRC
Outperform
Acceleron added to Alpha Generator List at FBR Capital
04/18/17
FBCO
04/18/17
INITIATION
Target $46
FBCO
Outperform
Acceleron assumed with an Outperform at Credit Suisse
Target $46.
05/17/17
GSCO
05/17/17
INITIATION
Target $20
GSCO
Sell
Acceleron initiated with a Sell at Goldman Sachs
Goldman analyst Terence Flynn initiated Acceleron with a Sell and a $20 price target saying Luspatercept is the key driver but most opportunities are already reflected in valuation. Flynn said Luspatercept Phase 3 data for two blood disorders isn't expected until mid-2018 and expects shares to be a relative underperformer given the lack of catalysts this year.
05/17/17
05/17/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. CoreSite Realty (COR) initiated with a Market Perform at Wells Fargo. 2. Acceleron (XLRN) initiated with a Sell at Goldman Sachs. 3. Cardinal Health (CAH) initiated with a Hold at Jefferies. 4. Concho Resources (CXO) assumed with an Overweight at Piper Jaffray. 5. Triangle Capital (TCAP) initiated with a Buy at Wunderlich. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

BABA

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1.75 (1.11%)

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Wal-Mart

$80.98

0.21 (0.26%)

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Earnings
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ATU

Actuant

$22.90

-0.2 (-0.87%)

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NVO

Novo Nordisk

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GOOG

Alphabet

$926.96

4.74 (0.51%)

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$944.27

6.19 (0.66%)

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4.74 (0.51%)

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SRUN

Silver Run

$10.19

0.01 (0.10%)

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Silver Run merging with Alta Mesa and Kingfisher Midstream into $3.8B company »

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HEI

Heico

$85.55

-0.87 (-1.01%)

18:37
08/16/17
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Downgrade
Heico rating change at Deutsche Bank »

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GPRK

GeoPark

$8.61

-0.13 (-1.49%)

18:36
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Earnings
GeoPark reports Q2 revenue $75.2M, consensus $70.38M »

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  • 17

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MEDP

Medpace

$31.21

-0.16 (-0.51%)

18:14
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TOUR

Tuniu

$7.76

-0.18 (-2.27%)

18:04
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Earnings
Tuniu reports Q2 EPS (11c), consensus (26c) »

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GLDD

Great Lakes Dredge

$3.85

-0.15 (-3.75%)

18:03
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Great Lakes Dredge CEO acquires 42,610 common shares »

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TISI

Team

$11.10

-0.25 (-2.20%)

18:00
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Team director Lois Waters purchases 17,500 shares of company stock »

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NTAP

NetApp

$42.41

0.44 (1.05%)

17:59
08/16/17
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Breaking Hot Stocks news story on NetApp »

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NTAP

NetApp

$42.41

0.44 (1.05%)

17:58
08/16/17
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Breaking Hot Stocks news story on NetApp »

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NTAP

NetApp

$42.42

0.44 (1.05%)

17:52
08/16/17
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Earnings
NetApp sees low double digit EPS growth for FY18, consensus $3.03 »

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SFST

Southern First Bancshares

$36.00

0.05 (0.14%)

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Southern First Bancshares CFO Michael Dowling sells 5,850 shares »

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  • 16

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BXE

Bellatrix Exploration

$2.40

-0.03 (-1.23%)

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NTAP

NetApp

$42.41

0.44 (1.05%)

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ACHN

Achillion

$4.88

-0.12 (-2.40%)

17:45
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Conference/Events
Achillion management to meet with William Blair »

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BCOR

Blucora

$23.35

0.1 (0.43%)

, BBOX

Black Box

$3.75

-0.25 (-6.25%)

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On The Fly: After Hours Movers »

HIGHER: Blucora (BCOR),…

BCOR

Blucora

$23.35

0.1 (0.43%)

BBOX

Black Box

$3.75

-0.25 (-6.25%)

BGG

Briggs & Stratton

$24.09

0.29 (1.22%)

LB

L Brands

$39.55

0.5 (1.28%)

VIPS

Vipshop

$11.10

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SPTN

SpartanNash

$25.96

0.07 (0.27%)

SNPS

Synopsys

$79.09

0.86 (1.10%)

CSCO

Cisco

$32.34

0.25 (0.78%)

NTAP

NetApp

$42.41

0.44 (1.05%)

LAKE

Lakeland Industries

$15.65

-0.25 (-1.57%)

GCP

GCP Applied Technologies

$28.75

0.1 (0.35%)

FNGN

Financial Engines

$34.35

-0.1 (-0.29%)

ACHC

Acadia

$51.68

-0.33 (-0.63%)

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ANDX

Andeavor Logistics

$46.94

0.12 (0.26%)

, WNRL

Western Refining Logistics

$24.25

0.1 (0.41%)

17:26
08/16/17
08/16
17:26
08/16/17
17:26
Upgrade
Andeavor Logistics, Western Refining Logistics rating change at MUFG »

Andeavor Logistics…

ANDX

Andeavor Logistics

$46.94

0.12 (0.26%)

WNRL

Western Refining Logistics

$24.25

0.1 (0.41%)

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GD

General Dynamics

$200.61

1.12 (0.56%)

17:22
08/16/17
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Hot Stocks
General Dynamics awarded $115.3M government contract modification »

General Dynamics Electric…

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  • 23

    Aug

BLVD

Boulevard Acquisition

$10.04

-0.01 (-0.10%)

17:17
08/16/17
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Hot Stocks
Breaking Hot Stocks news story on Boulevard Acquisition »

Glazer Capital reports…

03/08/13
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FMBH

First Mid-Illinois Bancshares

$34.85

-0.33 (-0.94%)

17:17
08/16/17
08/16
17:17
08/16/17
17:17
Syndicate
First Mid-Illinois Bancshares files to sell $20M of common stock 'at-the-market' »

First Mid-Illinois…

03/08/13
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  • 18

    Sep

NCOM

National Commerce

$39.55

0.1 (0.25%)

17:16
08/16/17
08/16
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17:16
Hot Stocks
National Commerce, FirstAtlantic Financial sign definitive merger agreement »

National Commerce…

03/08/13
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  • 18

    Sep

AMGN

Amgen

$171.39

1.35 (0.79%)

17:13
08/16/17
08/16
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17:13
Hot Stocks
Amgen: NEJM publishes results from Repatha cognitive function trial »

Amgen announced that the…

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