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NVO

Novo Nordisk

$43.47

0.63 (1.47%)

17:27
06/12/17
06/12
17:27
06/12/17
17:27

Novo Nordisk says 'DEVOTE' trial meets primary goal

Novo Nordisk announced primary results from DEVOTE, the first randomised, double-blind, treat-to-target, event-driven trial comparing two basal insulins, Tresiba and insulin glargine U100, in adults with type 2 diabetes at high risk of cardiovascular disease. The trial demonstrated that Tresiba met the primary endpoint of non-inferiority compared with insulin glargine U100 for major adverse CV events with a hazard ratio of 0.91. Additionally, the findings for each component of MACE were consistent with the overall endpoint, including first occurrence of CV death, non-fatal myocardial infarction or non-fatal stroke. Results were presented at the American Diabetes Association's annual meeting. Results from the secondary endpoints of the trial showed a significant reduction in the rate of severe -- 40% -- and nocturnal severe -- 53% -- hypoglycaemia with Tresiba vs. insulin glargine U100. Additionally, post hoc analyses showed similar levels of glycaemic control with an end of trial A1C estimated treatment difference of 0.01% between the two treatment groups and significantly lower fasting plasma glucose levels with Tresiba after 2 years vs. insulin glargine U100. The safety profile of Tresiba in DEVOTE was generally consistent with previous Tresiba clinical trials.

NVO Novo Nordisk
$43.47

0.63 (1.47%)

03/07/17
LEHM
03/07/17
NO CHANGE
LEHM
European Pharma raised to Positive from Neutral at Barclays
Barclays analyst Emmanuel Papadakis rolled out coverage of the European Pharmaceuticals space and upgraded his sector view to Positive from Neutral. The analyst has "high conviction that the recent transformational era of R&D innovation is set to continue," which he believes will allow the sector to retain pricing power. Papadakis put Overweight ratings on AstraZeneca (AZN), Roche (RHHBY) and Shire (SHPG), with Astra his top pick. The analyst put an Equal Weight rating on GlaxoSmithKline (GSK) and Underweight ratings on Sanofi (SNY), Novartis (NVS) and Novo Nordisk (NVO).
03/21/17
WEDB
03/21/17
INITIATION
WEDB
Outperform
Global Blood Therapeutics coverage assumed with an Outperform at Wedbush
Wedbush analyst Liana Moussatos says that Global Blood Therapeutics' (GBT) GBT440 drug can become the standard of care for sickle cell disease, and he thinks that the stock has not risen adequately following speculation that the company had been approached by Novo Nordisk(NVO) about a takeover. The analyst thinks that the company could be acquired for $73-$87 per share, versus its current price of around $37. Target $73.
04/07/17
HSBC
04/07/17
DOWNGRADE
HSBC
Reduce
Novo Nordisk downgraded to Reduce from Hold at HSBC
HSBC analyst Steve McGarry downgraded Novo Nordisk to Reduce to reflect lackluster news flow, valuation risk, and a sector backdrop where US pricing pressure could intensify.
04/07/17
04/07/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Lamb Weston (LW) downgraded to Hold from Buy at Stifel with analyst Christopher Growe citing the 44% up move in shares since he launched coverage in November 2016. 2. AstraZeneca (AZN), Novo Nordisk (NVO), Sanofi (SNY), Roche (RHHBY), and Grifols (GRFS) were downgraded to Reduce from Hold at HSBC. 3. AECOM (ACM) downgraded to Neutral from Outperform at Baird with analyst Andrew Wittmann saying the company filed an amendment to its credit agreement suggesting likely risk to 2017 earnings, as the filing implies the company would have breached its leverage covenant without an amendment. The analyst is also cautious given the relative obscurity of the filing. Wittmann lowered his price target to $40 from $45 on AECOM shares. 4. Arista Networks (ANET) downgraded to Neutral on valuation at Nomura with analyst Jeffrey Kvaal citing valuation. 5. Maximus (MMS) downgraded to Hold from Buy at Canaccord analyst Richard Close citing expectations of a slow near-term RFP and contract award environment given the recent Trump administration transition. click here.

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TMO

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SMBC

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IEP

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NVTA

Invitae

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NVTA

Invitae

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MU

Micron

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INSY

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AKTX

Akari Therapeutics

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JMBA

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HIL

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TGT

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ATW

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, ESV

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NSRGY

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