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SAGE

Sage Therapeutics

$74.32

0.01 (0.01%)

18:46
06/12/17
06/12
18:46
06/12/17
18:46

Sage Therapeutics reports 'positive' Phase 2 Brexanolone data

Sage Therapeutics announced that The Lancet has published results from a Phase 2, double-blind, randomized and placebo-controlled study of brexanolone in women with severe postpartum depression. The study found that treatment with brexanolone resulted in a clinically meaningful and statistically significant mean reduction in the 17-item Hamilton Rating Scale for Depression total score, a common measure of depression severity, that began at 24 hours and was maintained at similar magnitude until the 30-day follow-up. Brexanolone was well-tolerated in this study with no observations of deaths, serious adverse events or discontinuations. The study's primary efficacy endpoint was the mean change from baseline in the 17-item HAM-D total score in subjects who received brexanolone compared with subjects who received placebo at the 60-hour time point. As previously reported, at the end of the 60-hour infusion, brexanolone-treated subjects demonstrated a mean reduction in HAM-D total score of 20.97 points, a 12.2-point difference from placebo. The effect was statistically significant from 24 hours after initiation of treatment until the 30-day follow-up. No deaths, serious adverse events or discontinuations were observed. Overall, fewer patients who received brexanolone experienced adverse events compared with placebo. The most commonly reported adverse events in the trial were dizziness and somnolence and an equal number of patients reported the cluster of dizziness, sedation or somnolence.

  • 13

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    Jun

SAGE Sage Therapeutics
$74.32

0.01 (0.01%)

05/12/17
BOFA
05/12/17
INITIATION
Target $85
BOFA
Buy
SAGE Therapeutics initiated with a Buy at BofA/Merrill
BofA/Merrill analyst Tazeen Ahmad initiated SAGE Therapeutics with a Buy and an $85 price target saying the company has long-term opportunities in large addressable markets of central nervous system diseases, postpartum depression, major depressive disorder, essential tremor and symptoms of Parkinson's disease.
05/12/17
05/12/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Orion Engineered (OEC) initiated with a Neutral at Goldman Sachs. 2. National Grid (NGG) reinstated with an Equal Weight at Barclays. 3. SAGE Therapeutics (SAGE) initiated with a Buy at BofA/Merrill. 4. Quest Diagnostics (DGX) initiated with a Hold at Argus. 5. First Foundation (FFWM) initiated with a Neutral at Piper Jaffray. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
05/15/17
NEED
05/15/17
INITIATION
NEED
Buy
SAGE Therapeutics initiated with a Buy at Needham
Needham initiated SAGE Therapeutics with a Buy rating and $82 price target.
06/12/17
COWN
06/12/17
NO CHANGE
Target $95
COWN
Outperform
SAGE Therapeutics is a top smidcap pick at Cowen
Cowen analyst Ritu Baral said Sage Therapeutics is a top smidcap pick given high prospects for success of brexanolone in 2 Ph 3 pivotal trials in SRSE, data expected in Q3 and PPD, data expected in 2H 2017, based on strong Ph 2 data in each indication. Further, Baral sees value in SAGE's pipeline and notes several additional Ph 2 readouts expected throughout 2017, which have minimal current value and could provide further upside to shares. Baral rates SAGE an Outperform with a $95 price target.

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