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DMPI

DelMar Pharmaceuticals

$1.81

0.05 (2.84%)

08:37
06/16/17
06/16
08:37
06/16/17
08:37

DelMar Pharmaceuticals presents poster of research with VAL-083

The company's presentation entitled "Dianhydrogalactitol (VAL-083) overcomes p53-mediated chemo-resistance and displays synergy with topoisomerase inhibitors" was presented the evening of Thursday, June 15. The authors highlight the current absence of a viable standard-of-care for patients with pediatric high-grade gliomas. This is because the only approved agent for this indication, temozolomide, is rendered inactive due to pediatric brain tumors having a high expression of a TMZ-inactivating enzyme called MGMT and a low expression of the TMZ-activating MMR pathway proteins. In prior clinical trials, DelMar Pharmaceuticals' lead product candidate VAL-083 demonstrated activity against this dire pediatric cancer. The poster emphasizes the fact that VAL-083 maintains functionality regardless of the MGMT or MMR status of pHGG, and is also not affected by the p53 status of the cancer cells. In vitro, VAL-083 has been shown to cause a robust and irreversible S/G2 arrest of the cancer cells, potentially then leading to cancer cell apoptosis. The poster provides the rationale for a detailed clinical investigation of VAL-083 in pediatric high-grade gliomas both as a single agent or in combination with currently available therapies such as TMZ or topoisomerase inhibitors. VAL-083 has been granted an orphan drug designation by the U.S. FDA Office of Orphan Products for the treatment of glioma, medulloblastoma and ovarian cancer, and in Europe for the treatment of malignant gliomas.

DMPI DelMar Pharmaceuticals
$1.81

0.05 (2.84%)

01/05/17
AGIS
01/05/17
INITIATION
Target $16
AGIS
Buy
DelMar Pharmaceuticals initiated with a Buy at Aegis
Aegis analyst Robert LeBoyer initiated DelMar Pharmaceuticals with a Buy and a $16 price target.
11/16/16
MAXM
11/16/16
NO CHANGE
Target $11
MAXM
Buy
DelMar Pharmaceuticals price target lowered to $11 from $15 at Maxim
Maxim analyst Jason McCarthy lowered his price target on DelMar Pharmaceuticals to $11 from $15, citing extended timelines for the company's Phase 3 program in patients with progressive glioblastoma multiforme who have failed Avastin therapy, which has been pushed out "a bit into 2017." This pushes out a potential commercial launch to 2021, from 2020, estimates McCarthy, who keeps a Buy rating on DelMar shares.

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