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MGNX

MacroGenics

$18.24

0.48 (2.70%)

14:15
06/18/17
06/18
14:15
06/18/17
14:15

MacroGenics reports updated Phase 1 data on MGD010

MacroGenics announced the presentation of updated data from its Phase 1 study of MGD010 at the European League Against Rheumatism Annual European Congress of Rheumatology. The Company highlighted the immunomodulatory impact of MGD010 on the response to hepatitis A vaccination in normal healthy subjects. The data demonstrate that by pharmacologically exploiting the activity of the checkpoint molecule CD32B in combination with the B-cell receptor CD79B component, a single dose administration of MGD010 at either 3 or 10 mg/kg delivers an immunomodulatory effect that counters B-cell function, the company said. There were no CTCAE grade 3 or higher adverse events related to MGD010. Consistent with prior observations, ex vivo flow cytometric analysis confirmed dose-dependent MGD010 binding to peripheral B cells without B-cell depletion, accompanied by decreased surface BCR and CD40 expression as well as a decrease in total serum IgM levels. Compared to the placebo group, reduced HAV seroconversion rates were observed in subjects treated with MGD010, with significantly lower HA-specific IgG levels. "These results provide compelling rationale for further development of this therapeutic modality for autoimmune disorders," the company remarked.

MGNX MacroGenics
$18.24

0.48 (2.70%)

11/16/16
ROTH
11/16/16
INITIATION
Target $40
ROTH
Buy
MacroGenics reinstated with a Buy at Roth Capital
Roth Capital analyst Mark Breidenbach assumed coverage of MacroGenics with a Buy rating and $40 price target based on a sum-of-parts and the company's pipeline. As the company's lead program progresses in Phase 3 evaluation, Breidenbach believes several catalysts could whet investor appetites in the near term.
12/20/16
RHCO
12/20/16
INITIATION
Target $30
RHCO
Buy
MacroGenics initiated with a Buy at SunTrust
SunTrust analyst Peter Lawson initiated MacroGenics with a Buy and a $30 price target saying its DART technology is well positioned to rival CAR T cell therapy in cancer. Lawson would be a buyer of shares ahead of 2017 catalysts that include Enoblituzumab combo data, Phase 1/2 gastric combo data, Phase 1 DART data.
03/01/17
NOMU
03/01/17
INITIATION
Target $41
NOMU
Buy
MacroGenics initiated with a Buy at Nomura
Nomura initiated MacroGenics with a Buy and a $41 price target.
03/30/17
RAJA
03/30/17
INITIATION
Target $26
RAJA
Outperform
MacroGenics initiated with an Outperform at Raymond James
Raymond James analyst Reni Benjamin initiated MacroGenics with an Outperform and a $26 price target saying it is a unique "marquee" player in the bispecific antibody space. The analyst believes the value of MacroGenics' DART platform, the newsflow from multiple trials, the potential to sign additional global marquee partners, and a cash position of $245M represent an unique opportunity.

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