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JUNO

Juno Therapeutics

$23.29

0.77 (3.42%)

14:30
06/18/17
06/18
14:30
06/18/17
14:30

Juno Therapeutics reports data from 'TRANSCEND' trial of JCAR017

Juno Therapeutics presented data from the TRANSCEND trial of JCAR017 in relapsed and refractory aggressive B cell non-Hodgkin lymphoma at the International Conference on Malignant Lymphoma. "High rates of durable responses and the early survival data are especially exciting, as is the emerging safety profile. The majority of TRANSCEND patients experienced no cytokine release syndrome or neurotoxicity at all. While still early, these data suggest that JCAR017 could be administered on an outpatient basis," the company remarked. Data for the DLBCL cohort were presented in two groups, core and full. The core analysis group includes patients that represent the population that Juno plans to move forward into a pivotal trial in the second half of 2017. For the core group, findings include: Overall response rate is 86% and the complete response is 59%. Three-month ORR is 66% and CR is 50%. Of patients in response at three months, 90% continue in response at six months. Early data suggest a dose response relationship at three months. 97% of responding patients are alive and in follow-up as of May 4. 2% experienced severe CRS and 18% experienced severe NT. 66% did not experience any CRS or NT. No deaths were reported from CRS or NT. There was one Grade 5 adverse event of diffuse alveolar damage, which the investigator assessed as possibly related to fludarabine, cyclophosphamide, and JCAR017 treatment, occurring on day 23 in an 82-year-old subject who refused mechanical ventilation for progressive respiratory failure while neutropenic on growth factors and broad spectrum antibiotics and antifungals. This patient had no CRS and Grade 3 neurotoxicity resolution before the Grade 5 event. Regarding manufacturing Juno stated: "Product was available for 98% of patients apheresed... Juno expects commercial production will be accomplished in less than 21 days, and Juno is investing in manufacturing infrastructure to enable a smooth prescribing experience with a reliable delivery time at market entry."

  • 19

    Jun

JUNO Juno Therapeutics
$23.29

0.77 (3.42%)

06/08/17
06/08/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Juno Therapeutics (JUNO) downgraded to Sell from Neutral at BTIG with analyst Dane Leone saying that the company's treatment for CD19 and hematologic malignancies is on track to hit the market later than competing products, while there is no "demonstrated proof" that Juno will have any advantages in the areas of efficacy or toxicity. 2. National Grid (NGG) downgraded to Sell from Hold at Deutsche Bank with analyst James Brand saying the company's sustainable equity cash flow yield could drop below 6% after its next regulatory review. 3. BHP Billiton (BHP) downgraded to Hold from Buy at Jefferies with analyst Christopher LaFemina saying he believes the balance sheet recap trade in mining as well as the Chinese stimulus-driven recovery in demand is over. 4. Lear (LEA) downgraded to Underweight from Equal Weight at Morgan Stanley with analyst Adam Jonas saying he expects Lear's earnings to peak this year and to fall by 20% by 2021 and expects Electrical business margins to disappoint investors due to higher development costs, increased competition, and potential lost market share. 5. Hawaiian Holdings (HA) downgraded to Hold from Buy at Deutsche Bank with analyst Michael Linenberg saying the valuation is near full following the recent rally. The analyst raised his price target for the shares to $64 from $63. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
06/08/17
BTIG
06/08/17
DOWNGRADE
BTIG
Sell
Juno downgraded on lateness to market, lack of differentiation at BTIG
As noted earlier, BTIG downgraded Juno to Sell from Neutral. Analyst Dane Leone says that the company's treatment for CD19 and hematologic malignancies is on track to hit the market later than competing products, while there is no "demonstrated proof" that Juno will have any advantages in the areas of efficacy or toxicity. The analyst expects the revenue generated by Juno's JCAR017 treatment to come in about $1B below consensus expectations through 2026. Target $12.
06/08/17
06/08/17
UPGRADE
Target $100

Buy
Kite Pharma upgraded to Buy on Axi-Cel manufacturing edge at BTIG
As previously reported, BTIG analyst Dane Leone upgraded Kite Pharma (KITE) to Buy from Neutral and set a $100 price target on the shares. Data from Novartis (NVS) and Juno (JUNO) have failed to deliver any recognizable differentiation, though Leone gives Kite "a clear win" for the manufacturing of Axi-Cel versus peers, he tells investors. The analyst sees Kite having the cleanest pathway to approval for diffuse large B-cell lymphoma and, given Kite's manufacturing edge, he estimates that Axi-Cel can take about 60% of share within the U.S. DLBCL market.
06/08/17
BTIG
06/08/17
DOWNGRADE
BTIG
Sell
Juno Therapeutics downgraded to Sell from Neutral at BTIG

TODAY'S FREE FLY STORIES

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XLF

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NTRS

Northern Trust

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SBOT

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BBVA

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ZION

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MBUU

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STI

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BK

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  • 20

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CFG

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