Breaking News Instant updates and real-time market news.

TOCA

Tocagen

$14.95

0.39 (2.68%)

08:04
06/19/17
06/19
08:04
06/19/17
08:04

Tocagen: Preclinical data on 511 & Toca FC published in Neuro-Oncology

Tocagen announced the publication of preclinical data in Neuro-Oncology from two independent research programs which together detail proposed mechanisms of action for Toca 511 & Toca FC involving direct tumor killing and activation of the immune system against cancer cells. The papers were published in the July issue of Neuro-Oncology, which appeared in print on June 16, and were featured on the cover and highlighted in an editorial. The articles first appeared online on April 6. In the article titled, "Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable anti-tumor immunity in a mouse glioma model," Mitchell, et al., monitored and characterized immune cell populations in the tumor microenvironment in mouse models of brain cancer over the course of treatment with Toca 511 and 5-FC, the active component of the Toca FC tablets used in humans. Results showed treatment-induced loss of immune cell subsets that have been shown to contribute to the suppression of normal immune activity against cancer cells, including reduction of tumor associated macrophages, myeloid-derived suppressor cells and tumor associated monocytes. Depletion of immune-suppressive myeloid cells was followed by increases in CD4+ and CD8+ T cells which correlated with tumor reduction. Mice that cleared tumors following treatment with Toca 511 and 5-FC were protected against re-challenge with the same tumor type. Furthermore, successful adoptive cell transfer experiments using isolated immune cells from successfully treated animals confirmed anti-tumor immune responses were T cell-dependent. In the article titled, "Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anti-cancer immunity," Hiraoka and Inagaki, et al., performed molecular imaging of immune-deficient and immune-competent mouse models of brain cancer following treatment with Toca 511 and cycles of 5-FC. These studies were performed in the laboratory of Noriyuki Kasahara, M.D., Ph.D., professor of cell biology and pathology at the University of Miami. While long-term survival benefit was seen in both models, tumor was undetectable in immune-competent mice after three cycles of 5-FC. In contrast, immune-deficient mice required continuous treatment with cycles of 5-FC for long-term survival benefit, and tumor recurrence was still evident between cycles. After clearance of tumors in immune-competent mice by treatment with Toca 511 and 5-FC, long-term protection against future challenge with the same tumor type was seen. Long-term immune memory against the tumor was lost upon depletion of T cell subsets, indicating a T cell-dependent anti-tumor immune response. The complementary findings reported in these publications demonstrate that anti-tumor immune effects are T-cell dependent and correlate with depletion of immune-suppressive myeloid cells. Toca 511 & Toca FC is in clinical development for the treatment of recurrent high grade glioma, or HGG, a type of brain cancer. Tocagen has completed enrollment of the Phase 2 portion of a Phase 2/3 clinical trial and plans to report top-line results of the study in the first half of 2018. The U.S. FDA granted Toca 511 & Toca FC Breakthrough Therapy Designation for the treatment of patients with recurrent HGG.

TOCA Tocagen
$14.95

0.39 (2.68%)

05/08/17
STFL
05/08/17
INITIATION
STFL
Buy
Tocagen initiated at Stifel
As noted earlier, Stifel started coverage of Toca with a $24 price target and a Buy rating. Analyst Thomas Shrader says that data on the company's combination cancer treatment, TOCA-511 + TOCA-FC, in high grade glioma is "intriguing." "Most treated patients live longer than historical expectations and about 25% of patients experience profound responses lasting years and possibly representing a cure," he wrote. The analyst adds that "solid" data indicates that other types of solid tumors could be mitigated using the drug combination.
05/08/17
LEER
05/08/17
INITIATION
Target $19
LEER
Market Perform
Tocagen initiated with a Market Perform at Leerink
Leerink analyst Michael Schmidt started Tocagen with a Market Perform rating and $19 price target.
05/08/17
05/08/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Yext (YEXT) initiated with an Outperform at RBC Capital, with an Overweight at Piper Jaffray, with an Equal Weight at Morgan Stanley and with a Neutral at JPMorgan. 2. Netshoes (NETS) initiated with an Overweight at JPMorgan and with a Buy at Jefferies. 3. Tocagen (TOCA) initiated with a Buy at Stifel and with a Market Perform at Leerink. 4. Warrior Met Coal (HCC) initiated with an Outperform at BMO Capital, with an Overweight at Morgan Stanley, with an Outperform at Credit Suisse and with a Neutral at Citi. 5. Cadence Bancorporation (CADE) initiated with an Outperform at Raymond James. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
05/09/17
EVER
05/09/17
INITIATION
Target $28
EVER
Outperform
Tocagen initiated with an Outperform at Evercore ISI
Evercore ISI analyst Jonathan Miller initiated Tocagen with an Outperform and a $28 price target

TODAY'S FREE FLY STORIES

FOXA

21st Century Fox

$26.88

0.12 (0.45%)

, ONCE

Spark Therapeutics

$85.15

-1.95 (-2.24%)

20:04
09/24/17
09/24
20:04
09/24/17
20:04
Hot Stocks
On The Fly: Top five weekend stock stories »

Catch up on the…

FOXA

21st Century Fox

$26.88

0.12 (0.45%)

ONCE

Spark Therapeutics

$85.15

-1.95 (-2.24%)

AVXS

AveXis

$92.11

-4.03 (-4.19%)

RGNX

Regenxbio

$28.25

-1.15 (-3.91%)

BOLD

Audentes Therapeutics

$27.31

-0.1 (-0.36%)

VYGR

Voyager Therapeutics

$17.50

-0.22 (-1.24%)

ORCL

Oracle

$48.16

0.19 (0.40%)

GPRO

GoPro

$10.75

-0.19 (-1.74%)

XLNX

Xilinx

$69.33

0.42 (0.61%)

SNPS

Synopsys

$80.36

0.3 (0.37%)

CDNS

Cadence Design

$38.88

0.45 (1.17%)

SIX

Six Flags

$58.96

1.14 (1.97%)

HMC

Honda

$29.91

0.18 (0.61%)

IRBT

iRobot

$76.14

-3.8 (-4.75%)

AET

Aetna

$153.57

0.18 (0.12%)

ANTM

Anthem

$182.86

-0.64 (-0.35%)

CNC

Centene

$92.22

1.48 (1.63%)

CI

Cigna

$182.74

0.61 (0.33%)

HNT

Health Net

HUM

Humana

$239.09

0.45 (0.19%)

MOH

Molina Healthcare

$65.32

2.81 (4.50%)

UNH

UnitedHealth

$193.03

-2.18 (-1.12%)

WCG

WellCare

$167.16

1.1 (0.66%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Sep

  • 26

    Sep

  • 26

    Sep

  • 27

    Sep

  • 27

    Sep

  • 28

    Sep

  • 28

    Sep

  • 12

    Oct

  • 24

    Oct

  • 08

    Nov

  • 12

    Jan

NVCR

Novocure

$21.50

-0.1 (-0.46%)

18:27
09/24/17
09/24
18:27
09/24/17
18:27
Hot Stocks
Combination of Novocure Optune with Temozolomide demonstrates five-year survival »

Novocure announced today…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

TWX

Time Warner

$102.40

-0.09 (-0.09%)

, CMCSA

Comcast

$38.10

0.63 (1.68%)

17:10
09/24/17
09/24
17:10
09/24/17
17:10
Hot Stocks
Box Office Battle: 'Kingsman: The Golden Circle' easily wins weekend »

"Kingsman: The…

TWX

Time Warner

$102.40

-0.09 (-0.09%)

CMCSA

Comcast

$38.10

0.63 (1.68%)

CMCSK

Comcast

SNE

Sony

$37.50

0.04 (0.11%)

FOX

21st Century Fox

$26.43

0.1 (0.38%)

FOXA

21st Century Fox

$26.88

0.12 (0.45%)

LGF.A

Lionsgate

$31.49

0.24 (0.77%)

DIS

Disney

$98.60

-0.29 (-0.29%)

VIAB

Viacom

$27.64

0.24 (0.88%)

VIA

Viacom

$38.00

-0.2 (-0.52%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 27

    Sep

  • 29

    Sep

  • 22

    Oct

  • 26

    Oct

AMZN

Amazon.com

$955.10

-9.55 (-0.99%)

16:41
09/24/17
09/24
16:41
09/24/17
16:41
Periodicals
Amazon affiliate to buy stake in Indian retailer Shoppers Stop, Reuters says »

An affiliate of Amazon…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 03

    Oct

  • 22

    Oct

GOOGL

Alphabet Class A

$943.26

-4.29 (-0.45%)

, GOOG

Alphabet

$928.53

-3.92 (-0.42%)

16:37
09/24/17
09/24
16:37
09/24/17
16:37
Periodicals
Internet giants on the defensive in Washington, Reuters says »

Internet giants,…

GOOGL

Alphabet Class A

$943.26

-4.29 (-0.45%)

GOOG

Alphabet

$928.53

-3.92 (-0.42%)

FB

Facebook

$170.54

-0.57 (-0.33%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 03

    Oct

  • 22

    Oct

  • 29

    Nov

MOH

Molina Healthcare

$65.32

2.81 (4.50%)

, UNH

UnitedHealth

$193.03

-2.18 (-1.12%)

16:25
09/24/17
09/24
16:25
09/24/17
16:25
Periodicals
Opposition to new 'Obamacare' repeal bill grows, Reuters reports »

The new proposal by…

MOH

Molina Healthcare

$65.32

2.81 (4.50%)

UNH

UnitedHealth

$193.03

-2.18 (-1.12%)

CNC

Centene

$92.22

1.48 (1.63%)

WCG

WellCare

$167.16

1.1 (0.66%)

CI

Cigna

$182.74

0.61 (0.33%)

ANTM

Anthem

$182.86

-0.64 (-0.35%)

HNT

Health Net

HUM

Humana

$239.09

0.45 (0.19%)

AET

Aetna

$153.57

0.18 (0.12%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 26

    Sep

  • 27

    Sep

  • 24

    Oct

  • 08

    Nov

SAP

SAP

$110.27

0.64 (0.58%)

16:11
09/24/17
09/24
16:11
09/24/17
16:11
Hot Stocks
SAP announces acquisition of Gigya »

SAP has announced it has…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

TATT

TAT Technologies

$10.70

0.05 (0.47%)

, BA

Boeing

$256.45

0.41 (0.16%)

16:03
09/24/17
09/24
16:03
09/24/17
16:03
Hot Stocks
TAT Technologies awarded APU MRO contract for fleet of Boeing, Airbus »

TAT Technologies (TATT),…

TATT

TAT Technologies

$10.70

0.05 (0.47%)

BA

Boeing

$256.45

0.41 (0.16%)

EADSY

Airbus

$23.06

-0.01 (-0.04%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Sep

GM

General Motors

$39.42

0.32 (0.82%)

11:43
09/23/17
09/23
11:43
09/23/17
11:43
Periodicals
GM to eliminate shift at Tennessee SUV plant on 'moderating' sales, WSJ says »

General Motors has…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

WFC

Wells Fargo

$54.25

0.19 (0.35%)

11:34
09/23/17
09/23
11:34
09/23/17
11:34
Periodicals
Wells Fargo hires law firm to prepare CEO for Senate appearance, Reuters says »

Wells Fargo has hired law…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Sep

  • 03

    Oct

  • 13

    Oct

  • 22

    Oct

  • 29

    Nov

  • 15

    Jan

EADSY

Airbus

$23.06

-0.01 (-0.04%)

11:27
09/23/17
09/23
11:27
09/23/17
11:27
Periodicals
Airbus in talks to sell all or part of Premium Aerotec, Reuters says »

Airbus is said to be in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

DGX

Quest Diagnostics

$102.11

0.56 (0.55%)

11:06
09/23/17
09/23
11:06
09/23/17
11:06
Hot Stocks
Quest Diagnostics 'disappointed' with proposed PAMA 2018 Medicare payment rates »

Quest Diagnostics has…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 30

    Nov

IRBT

iRobot

$76.14

-3.8 (-4.75%)

10:58
09/23/17
09/23
10:58
09/23/17
10:58
Periodicals
iRobot suffering after onslaught of SharkNinja cheaper models, Barron's says »

In a follow up story,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

XLNX

Xilinx

$69.33

0.42 (0.61%)

, SNPS

Synopsys

$80.36

0.3 (0.37%)

10:47
09/23/17
09/23
10:47
09/23/17
10:47
Periodicals
Xilinx, Synopsys are 'rising stars' amid natural evolution of AI, Barron's says »

As everyday items get…

XLNX

Xilinx

$69.33

0.42 (0.61%)

SNPS

Synopsys

$80.36

0.3 (0.37%)

CDNS

Cadence Design

$38.88

0.45 (1.17%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 28

    Sep

UTX

United Technologies

$115.01

0.51 (0.45%)

, COL

Rockwell Collins

$130.48

0.09 (0.07%)

10:42
09/23/17
09/23
10:42
09/23/17
10:42
Periodicals
Major aircraft makers, suppliers face off, Barron's says »

While United Technologies…

UTX

United Technologies

$115.01

0.51 (0.45%)

COL

Rockwell Collins

$130.48

0.09 (0.07%)

BA

Boeing

$256.45

0.41 (0.16%)

EADSY

Airbus

$23.06

-0.01 (-0.04%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Sep

GPRO

GoPro

$10.75

-0.19 (-1.74%)

10:33
09/23/17
09/23
10:33
09/23/17
10:33
Periodicals
Key events may create 'short squeeze' in GoPro stock, Barron's says »

GoPro, a heavily shorted…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

HMC

Honda

$29.91

0.18 (0.61%)

, RACE

Ferrari

$113.47

-0.1 (-0.09%)

10:17
09/23/17
09/23
10:17
09/23/17
10:17
Periodicals
Honda $200,000 Acura NSX lacks Ferrari 'raw appeal,' Barron's says »

Acura, Honda's (HMC)…

HMC

Honda

$29.91

0.18 (0.61%)

RACE

Ferrari

$113.47

-0.1 (-0.09%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

ORCL

Oracle

$48.16

0.19 (0.40%)

10:07
09/23/17
09/23
10:07
09/23/17
10:07
Periodicals
Oracle shares could return 20% in a year, Barron's says »

Oracle is a latecomer to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SIX

Six Flags

$58.96

1.14 (1.97%)

09:59
09/23/17
09/23
09:59
09/23/17
09:59
Periodicals
Six Flags may have peaked, Barron's says »

Investors have had an…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 28

    Sep

ONCE

Spark Therapeutics

$85.15

-1.95 (-2.24%)

, AVXS

AveXis

$92.11

-4.03 (-4.19%)

09:51
09/23/17
09/23
09:51
09/23/17
09:51
Periodicals
Gene therapy may be nearing 'major breakthrough,' Baron's says »

Gene therapy is rapidly…

ONCE

Spark Therapeutics

$85.15

-1.95 (-2.24%)

AVXS

AveXis

$92.11

-4.03 (-4.19%)

RGNX

Regenxbio

$28.25

-1.15 (-3.91%)

BOLD

Audentes Therapeutics

$27.31

-0.1 (-0.36%)

VYGR

Voyager Therapeutics

$17.50

-0.22 (-1.24%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Sep

  • 26

    Sep

  • 27

    Sep

  • 12

    Oct

  • 12

    Jan

  • 22

    Sep

AET

Aetna

$153.57

0.18 (0.12%)

, ANTM

Anthem

$182.86

-0.64 (-0.35%)

09:25
09/23/17
09/23
09:25
09/23/17
09:25
Hot Stocks
Week in review: How Trump's policies moved stocks »

Catch up on the top…

AET

Aetna

$153.57

0.18 (0.12%)

ANTM

Anthem

$182.86

-0.64 (-0.35%)

CNC

Centene

$92.22

1.48 (1.63%)

CI

Cigna

$182.74

0.61 (0.33%)

HNT

Health Net

HUM

Humana

$239.09

0.45 (0.19%)

MOH

Molina Healthcare

$65.32

2.81 (4.50%)

UNH

UnitedHealth

$193.03

-2.18 (-1.12%)

WCG

WellCare

$167.16

1.1 (0.66%)

AOBC

American Outdoor Brands

$15.01

-0.15 (-0.99%)

RGR

Sturm, Ruger

$51.00

-1.85 (-3.50%)

WMT

Wal-Mart

$79.53

-0.48 (-0.60%)

PEP

PepsiCo

$111.85

-0.95 (-0.84%)

TGT

Target

$58.99

0.66 (1.13%)

AAPL

Apple

$151.89

-1.5 (-0.98%)

MSFT

Microsoft

$74.41

0.2 (0.27%)

AMZN

Amazon.com

$955.10

-9.55 (-0.99%)

TWTR

Twitter

$17.61

0.03 (0.17%)

GOOGL

Alphabet Class A

$943.26

-4.29 (-0.45%)

GOOG

Alphabet

$928.53

-3.92 (-0.42%)

FB

Facebook

$170.54

-0.57 (-0.33%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Sep

  • 26

    Sep

  • 27

    Sep

  • 27

    Sep

  • 02

    Oct

  • 03

    Oct

  • 04

    Oct

  • 10

    Oct

  • 22

    Oct

  • 24

    Oct

  • 08

    Nov

  • 16

    Nov

  • 21

    Nov

  • 29

    Nov

  • 20

    Feb

AVA

Avista

$51.40

0.1 (0.19%)

18:47
09/22/17
09/22
18:47
09/22/17
18:47
Hot Stocks
Avista receives commission decision in Oregon natural gas rate case »

Avista's natural gas…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 05

    Nov

BMWYY

BMW

$34.00

0.083 (0.24%)

18:40
09/22/17
09/22
18:40
09/22/17
18:40
Periodicals
BMW to build new 8 series in Dingolfing from 2018, Reuters reports »

BMW intends to build its…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

CSCO

Cisco

$33.37

0.67 (2.05%)

18:20
09/22/17
09/22
18:20
09/22/17
18:20
Hot Stocks
Cisco completes acquisition of Springpath »

Cisco announced that it…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Sep

  • 22

    Sep

  • 25

    Sep

  • 26

    Sep

  • 28

    Sep

  • 29

    Sep

  • 05

    Oct

  • 06

    Oct

  • 18

    Oct

  • 19

    Oct

  • 22

    Oct

  • 15

    Nov

  • 07

    Dec

  • 11

    Dec

BMY

Bristol-Myers

$63.36

0.03 (0.05%)

18:12
09/22/17
09/22
18:12
09/22/17
18:12
Hot Stocks
Bristol-Myers announces FDA approval of Opdivo »

Bristol-Myers announced…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Sep

  • 25

    Sep

  • 26

    Sep

  • 27

    Sep

  • 18

    Oct

  • 26

    Oct

  • 08

    Nov

  • 09

    Nov

  • 05

    Mar

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.