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IONS

Ionis Pharmaceuticals

$51.60

-0.12 (-0.23%)

07:07
07/17/17
07/17
07:07
07/17/17
07:07

Ionis Pharmaceuticals earns $10M milestone payment from Biogen

Ionis Pharmaceuticals (IONS) announced that it has earned a $10M milestone payment from Biogen (BIIB) associated with the validation of an undisclosed neurological disease target. Ionis and Biogen have a broad strategic collaboration to develop drugs to treat patients with neurological disorders. Ionis will continue to evaluate this newest target with the goal of advancing this program into development.

IONS Ionis Pharmaceuticals
$51.60

-0.12 (-0.23%)

05/17/17
LTCO
05/17/17
NO CHANGE
Target $80
LTCO
Buy
Alnylam price target raised to $80 from $75 at Ladenburg
Ladenburg Thalmann analyst Christopher James raised his price target for Alnylam (ALNY) to $80 saying the NEURO-TTR data reported by Ionis Pharmaceuticals (IONS) are "quite positive" for patisiran and the upcoming APOLLO readout. The analyst reiterates a Buy rating on Alnylam shares.
05/16/17
PIPR
05/16/17
NO CHANGE
Target $69
PIPR
Overweight
Piper Jaffray sees positive readthrough for Prothena from Ionis data
Piper Jaffray analyst Steven Breazzano argues that investors should "take a closer look" at Prothena (PRTA) and its PRX004 product following the recent amyloid neuropathy data from Ionis Pharmaceuticals (IONS). Prothena's candidate is expected to enter the clinic in early 2018, and Breazzano argues that there is "room for differentiation" in the space, as the drug clears the protein buildup that characterizes amyloidosis rather than directly shutting off production, as with Ionis and Alnylam's (ALNY) approaches. "At a minimum," the analyst says, a deposit-clearing approach would be complementary to production-stopping drugs. Breazzano reiterates an Overweight rating on Prothena.
05/16/17
LEER
05/16/17
NO CHANGE
Target $67
LEER
Outperform
Alnylam price target raised to $67 from $53 at Leerink
Leerink analyst Paul Matteis expects yesterday's data from Ionis Pharmaceuticals (IONS) will put TTRrx at a commercial disadvantage to Alnylam's (ALNY) patisiran. The top-line results for TTRrx, which showed high efficacy and several safety issues, is the best case for Alnylam, Matteis tells investors in a research note. He raised his odds of approval for both programs but lowered his price target for Ionis to $45 from $47. Matteis has Market Perform ratings on both stocks.
05/16/17
RHCO
05/16/17
NO CHANGE
RHCO
Prothena has positive read through from Ionis safety issues, says SunTrust
SunTrust analyst Yun Zhong says that safety issues with Ionis' inotersen during a Phase III trial are positive for Prothena. The analyst says that Prothena's new drug, PRX004, could have a better safety profile than its previous drug, NEOD001,. He notes that PRX004 has a different mechanism of action than Ionis' drug, and he thinks the discrepancy could enable Prthena's drug to have a better safety profile. He keeps a Buy rating on Prothena.

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BMRN

BioMarin

$93.54

-1.12 (-1.18%)

12:29
10/18/17
10/18
12:29
10/18/17
12:29
Earnings
BioMarin sees 2017 product revenue at mid-point of guidance »

BioMarin said that at…

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EQT

EQT Corporation

$62.94

-0.3799 (-0.60%)

12:25
10/18/17
10/18
12:25
10/18/17
12:25
Options
EQT Corporation call volume above normal and directionally bullish »

Bullish option flow…

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NLSN

Nielsen

$41.06

1.06 (2.65%)

, LGF

Use LGF.A, LGF.B

12:20
10/18/17
10/18
12:20
10/18/17
12:20
Hot Stocks
Nielsen to independently measure subscription-based streaming content. »

Nielsen announced that…

NLSN

Nielsen

$41.06

1.06 (2.65%)

LGF

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DIS

Disney

$97.64

-0.7161 (-0.73%)

TWX

Time Warner

$101.12

-0.34 (-0.34%)

NFLX

Netflix

$199.48

-3.2 (-1.58%)

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$NSD

NASDAQ Market Internals

12:17
10/18/17
10/18
12:17
10/18/17
12:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

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$NYE

NYSE Market Internals

12:16
10/18/17
10/18
12:16
10/18/17
12:16
Technical Analysis
NYSE market internals summary »

Volume is below average…

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MOBL

MobileIron

$3.80

-0.1 (-2.56%)

12:10
10/18/17
10/18
12:10
10/18/17
12:10
Downgrade
MobileIron rating change  »

MobileIron downgraded to…

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MBI

MBIA

$7.08

0.07 (1.00%)

12:10
10/18/17
10/18
12:10
10/18/17
12:10
Options
Far downside put buyer in MBIA opens a notable new position »

Far downside put buyer in…

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MOBL

MobileIron

$3.80

-0.1 (-2.56%)

12:07
10/18/17
10/18
12:07
10/18/17
12:07
Downgrade
MobileIron rating change  »

MobileIron downgraded to…

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STLD

Steel Dynamics

12:06
10/18/17
10/18
12:06
10/18/17
12:06
Technical Analysis
Technical Earnings Preview: Steel Dynamics has a potential bullish pattern »

On a very long-term…

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DANOY

Danone

$16.67

0.3 (1.83%)

12:05
10/18/17
10/18
12:05
10/18/17
12:05
Hot Stocks
Danone names Emmanuel Faber as both Chairman and CEO »

Danone announced that its…

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NFLX

Netflix

$199.48

-3.2 (-1.58%)

12:00
10/18/17
10/18
12:00
10/18/17
12:00
Options
Large four-way option spread in Netflix as shares slump for a second day »

Large four-way option…

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  • 22

    Oct

12:00
10/18/17
10/18
12:00
10/18/17
12:00
General news
Treasury Action: TIPS are weaker »

Treasury Action: TIPS are…

ADBE

Adobe

$150.38

-0.08 (-0.05%)

11:55
10/18/17
10/18
11:55
10/18/17
11:55
Hot Stocks
Adobe announces acquisition of KyleBrush.com; terms not disclosed »

Adobe announces in a blog…

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GMLP

Golar LNG Partners

$22.98

-0.08 (-0.35%)

11:50
10/18/17
10/18
11:50
10/18/17
11:50
Options
Notable call write in Golar LNG Partners »

Notable call write in…

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11:50
10/18/17
10/18
11:50
10/18/17
11:50
General news
FX Action: USD-JPY »

FX Action: USD-JPY…

IPXL

Impax

$19.30

-0.65 (-3.26%)

11:45
10/18/17
10/18
11:45
10/18/17
11:45
Conference/Events
Impax management to meet with Deutsche Bank »

Group luncheon to be held…

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BITCOIN

Bitcoin

11:44
10/18/17
10/18
11:44
10/18/17
11:44
Hot Stocks
Bitcoin falls after release of CFTC report on virtual currencies »

The U.S. Commodity…

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EBAY

eBay

$37.49

-0.28 (-0.74%)

, SHOP

Shopify

$98.14

1.93 (2.01%)

11:41
10/18/17
10/18
11:41
10/18/17
11:41
Earnings
On The Fly: What to watch in eBay earnings report »

eBay (EBAY) is scheduled…

EBAY

eBay

$37.49

-0.28 (-0.74%)

SHOP

Shopify

$98.14

1.93 (2.01%)

AMZN

Amazon.com

$1,009.13

2.79 (0.28%)

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XOP

SPDR Oil Exploration and Production Fund

$33.41

-0.26 (-0.77%)

11:40
10/18/17
10/18
11:40
10/18/17
11:40
Options
Hefty put spread in SPDR Oil Exploration and Production ETF »

Hefty put spread in SPDR…

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11:40
10/18/17
10/18
11:40
10/18/17
11:40
General news
Atlanta Fed's Q3 GDPNow estimate was unchanged at 2.7% »

Atlanta Fed's Q3…

HLF

Herbalife

$76.52

-1.06 (-1.37%)

11:35
10/18/17
10/18
11:35
10/18/17
11:35
Options
Herbalife put volume heavy and directionally bearish »

Bearish flow noted in…

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  • 02

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AMZN

Amazon.com

$1,009.13

2.79 (0.28%)

, NFLX

Netflix

$199.48

-3.2 (-1.58%)

11:26
10/18/17
10/18
11:26
10/18/17
11:26
Hot Stocks
Amazon Studios head Roy Price officially resigns amid harassment claims »

Shares of Amazon.com…

AMZN

Amazon.com

$1,009.13

2.79 (0.28%)

NFLX

Netflix

$199.48

-3.2 (-1.58%)

AAPL

Apple

$160.47

0.59 (0.37%)

CMCSA

Comcast

$36.47

-0.14 (-0.38%)

CMCSK

Comcast

DIS

Disney

$97.79

-0.57 (-0.58%)

FOX

21st Century Fox

$26.22

0.12 (0.46%)

FOXA

21st Century Fox

$26.88

0.19 (0.71%)

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CF

CF Industries

$36.41

-0.59 (-1.59%)

11:25
10/18/17
10/18
11:25
10/18/17
11:25
Options
CF Industries call volume above normal and directionally bullish »

Bullish option flow…

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  • 02

    Nov

OKSB

Southwest Bancorp

$27.75

-0.3 (-1.07%)

, SFNC

Simmons First National

$58.00

-0.9 (-1.53%)

11:25
10/18/17
10/18
11:25
10/18/17
11:25
Conference/Events
Simmons First National to host special shareholder meeting »

Special Shareholder…

OKSB

Southwest Bancorp

$27.75

-0.3 (-1.07%)

SFNC

Simmons First National

$58.00

-0.9 (-1.53%)

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11:20
10/18/17
10/18
11:20
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General news
Energy Action: NYMEX crude »

Energy Action: NYMEX…

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