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IONS

Ionis Pharmaceuticals

$51.60

-0.12 (-0.23%)

07:07
07/17/17
07/17
07:07
07/17/17
07:07

Ionis Pharmaceuticals earns $10M milestone payment from Biogen

Ionis Pharmaceuticals (IONS) announced that it has earned a $10M milestone payment from Biogen (BIIB) associated with the validation of an undisclosed neurological disease target. Ionis and Biogen have a broad strategic collaboration to develop drugs to treat patients with neurological disorders. Ionis will continue to evaluate this newest target with the goal of advancing this program into development.

IONS Ionis Pharmaceuticals
$51.60

-0.12 (-0.23%)

05/17/17
LTCO
05/17/17
NO CHANGE
Target $80
LTCO
Buy
Alnylam price target raised to $80 from $75 at Ladenburg
Ladenburg Thalmann analyst Christopher James raised his price target for Alnylam (ALNY) to $80 saying the NEURO-TTR data reported by Ionis Pharmaceuticals (IONS) are "quite positive" for patisiran and the upcoming APOLLO readout. The analyst reiterates a Buy rating on Alnylam shares.
05/16/17
PIPR
05/16/17
NO CHANGE
Target $69
PIPR
Overweight
Piper Jaffray sees positive readthrough for Prothena from Ionis data
Piper Jaffray analyst Steven Breazzano argues that investors should "take a closer look" at Prothena (PRTA) and its PRX004 product following the recent amyloid neuropathy data from Ionis Pharmaceuticals (IONS). Prothena's candidate is expected to enter the clinic in early 2018, and Breazzano argues that there is "room for differentiation" in the space, as the drug clears the protein buildup that characterizes amyloidosis rather than directly shutting off production, as with Ionis and Alnylam's (ALNY) approaches. "At a minimum," the analyst says, a deposit-clearing approach would be complementary to production-stopping drugs. Breazzano reiterates an Overweight rating on Prothena.
05/16/17
LEER
05/16/17
NO CHANGE
Target $67
LEER
Outperform
Alnylam price target raised to $67 from $53 at Leerink
Leerink analyst Paul Matteis expects yesterday's data from Ionis Pharmaceuticals (IONS) will put TTRrx at a commercial disadvantage to Alnylam's (ALNY) patisiran. The top-line results for TTRrx, which showed high efficacy and several safety issues, is the best case for Alnylam, Matteis tells investors in a research note. He raised his odds of approval for both programs but lowered his price target for Ionis to $45 from $47. Matteis has Market Perform ratings on both stocks.
05/16/17
RHCO
05/16/17
NO CHANGE
RHCO
Prothena has positive read through from Ionis safety issues, says SunTrust
SunTrust analyst Yun Zhong says that safety issues with Ionis' inotersen during a Phase III trial are positive for Prothena. The analyst says that Prothena's new drug, PRX004, could have a better safety profile than its previous drug, NEOD001,. He notes that PRX004 has a different mechanism of action than Ionis' drug, and he thinks the discrepancy could enable Prthena's drug to have a better safety profile. He keeps a Buy rating on Prothena.

TODAY'S FREE FLY STORIES

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LUV

Southwest

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-1.96 (-3.29%)

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AAPL

Apple

$153.46

0.72 (0.47%)

12:34
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Periodicals
Apple confirms discontinuation of iPod nano, shuffle, The Verge reports »

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HOG

Harley-Davidson

$49.96

1.32 (2.71%)

12:30
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Heavy call activity in Harley Davidson as shares rally »

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Atlanta Fed's final Q2 GDPNow estimate was boosted to 2.8% »

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VBIV

VBI Vaccines

$4.61

-0.03 (-0.65%)

12:25
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Conference/Events
VBI Vaccines to host conference call »

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DAL

Delta Air Lines

$50.74

-0.395 (-0.77%)

, AFLYY

Air France-KLM

$14.14

0.18 (1.29%)

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DAL

Delta Air Lines

$50.74

-0.395 (-0.77%)

AFLYY

Air France-KLM

$14.14

0.18 (1.29%)

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GG

Goldcorp

$12.88

-0.91 (-6.60%)

12:20
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Options
Repeat activity in GoldCorp after earnings »

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12:20
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General news
Treasury Option Action: heavy put activity »

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$NSD

NASDAQ Market Internals

12:17
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NASDAQ market internals summary »

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$NYE

NYSE Market Internals

12:16
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NYSE market internals summary »

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W

Wayfair

$78.91

-0.4533 (-0.57%)

12:15
07/27/17
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Options
Wayfair put volume heavy and directionally bearish »

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TDOC

Teladoc

$31.78

-2.575 (-7.50%)

, AMZN

Amazon.com

$1,052.80

12.93 (1.24%)

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TDOC

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$31.78

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AMZN

Amazon.com

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SBUX

Starbucks

$57.94

-0.61 (-1.04%)

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AAPL

Apple

$153.46

0.72 (0.47%)

12:06
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NTES

NetEase

$312.15

3.26 (1.06%)

12:05
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Options
NetEase call volume above normal and directionally bullish »

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WABC

Westamerica

$54.57

-1.82 (-3.23%)

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Treasury's $20 B 14-day cash management bill saw pretty good demand »

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INTC

Intel

$34.75

0.08 (0.23%)

12:00
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Periodicals
Intel sells four offices buildings, development center in Alameda, SVBJ says »

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HOG

Harley-Davidson

$49.03

0.39 (0.80%)

, TSLA

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HOG

Harley-Davidson

$49.03

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TSLA

Tesla

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4.25 (1.25%)

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RYAM

Rayonier Advanced Materials

$15.72

-0.11 (-0.69%)

11:56
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Tembec shareholders approve deal with Rayonier Advanced Materials »

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TKC

Turkcell

$9.29

0.29 (3.22%)

11:55
07/27/17
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Breaking Hot Stocks news story on Turkcell 

Turkcell trading resumes

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FOSL

Fossil

$10.83

-0.19 (-1.72%)

11:55
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Breaking Hot Stocks news story on Fossil »

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