Breaking News Instant updates and real-time market news.

DRNA

Dicerna

$3.26

-0.06 (-1.81%)

07:07
07/17/17
07/17
07:07
07/17/17
07:07

Dicerna presents preclinical data on DCR-PHXC

Dicerna Pharmaceuticals presented on July 15, new preclinical data suggesting the potential utility of DCR-PHXC, a GalXC-based investigational therapy, for treating all forms of primary hyperoxaluria. In a series of presentations at the 12th International Workshop on Primary Hyperoxaluria for Professionals, Patients and Families in Tenerife, Spain from July 14-16, 2017, Dicerna scientists presented research from animal models demonstrating how DCR-PHXC inhibits the lactate dehydrogenase A gene, which Dicerna has identified as potentially being an optimal therapeutic target in patients with PH, a group of severe, rare, inherited disorders of the liver that often result in kidney failure. In patients with PH, the liver over-produces oxalate, a metabolite that can accumulate throughout the body and particularly in the kidneys, often resulting in end-stage renal disease and the need for both kidney and liver transplants. DCR-PHXC, the lead investigational product candidate in Dicerna's pipeline of therapies targeting rare diseases of the liver, yields potent, liver-specific LDHA inhibition in animal models of PH, an effect that reduces oxalate to near-normal levels, which may prevent the damage caused to kidneys and other organs by oxalate accumulation. At the 12th International Workshop, Dicerna presented research findings on LDHA inhibition, which was shown in animal models to reduce oxalate to normal or near-normal levels in PH types 1, 2, and ethylene glycol-induced PH. In contrast, research findings showed that inhibiting the enzyme glycolate oxidase -- a common target of investigational therapies for PH, including Dicerna's earlier IV-administered program for PH1 -- does not appear to have the potential to treat PH2 or IPH. In animal models of PH2 and ethylene glycol-induced PH, LDHA knockdown with DCR-PHXC nearly normalized oxalate levels within one-month post-treatment, whereas oxalate levels remained unchanged and elevated in animals receiving GO-targeted therapy. LDHA reduction has a linear correlation with oxalate reduction and offers a minimal metabolic intervention, unlike GO reduction. These benefits of LDHA inhibition may translate into consistent therapeutic activity even in the event of a missed dose. There are numerous case reports of LDHA deficiency naturally occurring in humans, with no reported adverse effects due to deficiency in the liver.

DRNA Dicerna
$3.26

-0.06 (-1.81%)

05/23/17
HCWC
05/23/17
INITIATION
Target $5
HCWC
Buy
Dicerna assumed with a Buy at H.C. Wainwright
H.C. Wainwright analyst Ed Arce assumed coverage of Dicerna Pharmaceuticals with a Buy rating and $5 price target.
01/31/17
LEER
01/31/17
INITIATION
Target $4
LEER
Market Perform
Dicerna assumed with a Market Perform at Leerink
Leerink analyst Paul Matteis assumed coverage of Dicerna with a Market Perform rating and $4 price target. While the analyst believes the company's pipeline has long-term clinical potential, nearer term he is somewhat concerned by its limited cash runway and lack of news flow.
12/12/16
HCWC
12/12/16
INITIATION
Target $7
HCWC
Buy
Dicerna initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Shaunak Deepak started Dicerna Pharmaceuticals with a Buy rating and $7 price target.
11/08/16
LEER
11/08/16
NO CHANGE
Target $8
LEER
Outperform
Dicerna price target lowered to $8 from $18 at Leerink
Following Q3 results and pipeline updates, Leerink analyst Michael Schmidt lowered his price target for Dicerna to $8 from $18 to reflect discontinuation of the DCR-MYC program and a lower probability-of-success of DCR-PHXC to account for additional clinical development risk on novel RNAi platforms. The analyst reiterates an Outperform rating on the shares.

TODAY'S FREE FLY STORIES

EQT

EQT Corporation

$62.94

-0.3799 (-0.60%)

12:25
10/18/17
10/18
12:25
10/18/17
12:25
Options
EQT Corporation call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 26

    Oct

  • 14

    Nov

NLSN

Nielsen

$41.06

1.06 (2.65%)

, LGF

Use LGF.A, LGF.B

12:20
10/18/17
10/18
12:20
10/18/17
12:20
Hot Stocks
Nielsen to independently measure subscription-based streaming content. »

Nielsen announced that…

NLSN

Nielsen

$41.06

1.06 (2.65%)

LGF

Use LGF.A, LGF.B

DIS

Disney

$97.64

-0.7161 (-0.73%)

TWX

Time Warner

$101.12

-0.34 (-0.34%)

NFLX

Netflix

$199.48

-3.2 (-1.58%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Oct

  • 25

    Oct

  • 09

    Nov

$NSD

NASDAQ Market Internals

12:17
10/18/17
10/18
12:17
10/18/17
12:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

$NYE

NYSE Market Internals

12:16
10/18/17
10/18
12:16
10/18/17
12:16
Technical Analysis
NYSE market internals summary »

Volume is below average…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MOBL

MobileIron

$3.80

-0.1 (-2.56%)

12:10
10/18/17
10/18
12:10
10/18/17
12:10
Downgrade
MobileIron rating change  »

MobileIron downgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MBI

MBIA

$7.08

0.07 (1.00%)

12:10
10/18/17
10/18
12:10
10/18/17
12:10
Options
Far downside put buyer in MBIA opens a notable new position »

Far downside put buyer in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MOBL

MobileIron

$3.80

-0.1 (-2.56%)

12:07
10/18/17
10/18
12:07
10/18/17
12:07
Downgrade
MobileIron rating change  »

MobileIron downgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

STLD

Steel Dynamics

12:06
10/18/17
10/18
12:06
10/18/17
12:06
Technical Analysis
Technical Earnings Preview: Steel Dynamics has a potential bullish pattern »

On a very long-term…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 19

    Oct

DANOY

Danone

$16.67

0.3 (1.83%)

12:05
10/18/17
10/18
12:05
10/18/17
12:05
Hot Stocks
Danone names Emmanuel Faber as both Chairman and CEO »

Danone announced that its…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

NFLX

Netflix

$199.48

-3.2 (-1.58%)

12:00
10/18/17
10/18
12:00
10/18/17
12:00
Options
Large four-way option spread in Netflix as shares slump for a second day »

Large four-way option…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Oct

12:00
10/18/17
10/18
12:00
10/18/17
12:00
General news
Treasury Action: TIPS are weaker »

Treasury Action: TIPS are…

ADBE

Adobe

$150.38

-0.08 (-0.05%)

11:55
10/18/17
10/18
11:55
10/18/17
11:55
Hot Stocks
Adobe announces acquisition of KyleBrush.com; terms not disclosed »

Adobe announces in a blog…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 18

    Oct

  • 22

    Oct

  • 06

    Nov

GMLP

Golar LNG Partners

$22.98

-0.08 (-0.35%)

11:50
10/18/17
10/18
11:50
10/18/17
11:50
Options
Notable call write in Golar LNG Partners »

Notable call write in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

11:50
10/18/17
10/18
11:50
10/18/17
11:50
General news
FX Action: USD-JPY »

FX Action: USD-JPY…

IPXL

Impax

$19.30

-0.65 (-3.26%)

11:45
10/18/17
10/18
11:45
10/18/17
11:45
Conference/Events
Impax management to meet with Deutsche Bank »

Group luncheon to be held…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 18

    Oct

  • 09

    Nov

BITCOIN

Bitcoin

11:44
10/18/17
10/18
11:44
10/18/17
11:44
Hot Stocks
Bitcoin falls after release of CFTC report on virtual currencies »

The U.S. Commodity…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

EBAY

eBay

$37.49

-0.28 (-0.74%)

, SHOP

Shopify

$98.14

1.93 (2.01%)

11:41
10/18/17
10/18
11:41
10/18/17
11:41
Earnings
On The Fly: What to watch in eBay earnings report »

eBay (EBAY) is scheduled…

EBAY

eBay

$37.49

-0.28 (-0.74%)

SHOP

Shopify

$98.14

1.93 (2.01%)

AMZN

Amazon.com

$1,009.13

2.79 (0.28%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 18

    Oct

  • 22

    Oct

  • 26

    Oct

  • 14

    Nov

  • 18

    Mar

XOP

SPDR Oil Exploration and Production Fund

$33.41

-0.26 (-0.77%)

11:40
10/18/17
10/18
11:40
10/18/17
11:40
Options
Hefty put spread in SPDR Oil Exploration and Production ETF »

Hefty put spread in SPDR…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

11:40
10/18/17
10/18
11:40
10/18/17
11:40
General news
Atlanta Fed's Q3 GDPNow estimate was unchanged at 2.7% »

Atlanta Fed's Q3…

HLF

Herbalife

$76.52

-1.06 (-1.37%)

11:35
10/18/17
10/18
11:35
10/18/17
11:35
Options
Herbalife put volume heavy and directionally bearish »

Bearish flow noted in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 02

    Nov

AMZN

Amazon.com

$1,009.13

2.79 (0.28%)

, NFLX

Netflix

$199.48

-3.2 (-1.58%)

11:26
10/18/17
10/18
11:26
10/18/17
11:26
Hot Stocks
Amazon Studios head Roy Price officially resigns amid harassment claims »

Shares of Amazon.com…

AMZN

Amazon.com

$1,009.13

2.79 (0.28%)

NFLX

Netflix

$199.48

-3.2 (-1.58%)

AAPL

Apple

$160.47

0.59 (0.37%)

CMCSA

Comcast

$36.47

-0.14 (-0.38%)

CMCSK

Comcast

DIS

Disney

$97.79

-0.57 (-0.58%)

FOX

21st Century Fox

$26.22

0.12 (0.46%)

FOXA

21st Century Fox

$26.88

0.19 (0.71%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 18

    Oct

  • 22

    Oct

  • 26

    Oct

  • 26

    Oct

  • 01

    Nov

  • 02

    Nov

  • 08

    Nov

  • 09

    Nov

  • 18

    Mar

CF

CF Industries

$36.41

-0.59 (-1.59%)

11:25
10/18/17
10/18
11:25
10/18/17
11:25
Options
CF Industries call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 02

    Nov

OKSB

Southwest Bancorp

$27.75

-0.3 (-1.07%)

, SFNC

Simmons First National

$58.00

-0.9 (-1.53%)

11:25
10/18/17
10/18
11:25
10/18/17
11:25
Conference/Events
Simmons First National to host special shareholder meeting »

Special Shareholder…

OKSB

Southwest Bancorp

$27.75

-0.3 (-1.07%)

SFNC

Simmons First National

$58.00

-0.9 (-1.53%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 18

    Oct

  • 23

    Oct

11:20
10/18/17
10/18
11:20
10/18/17
11:20
General news
Energy Action: NYMEX crude »

Energy Action: NYMEX…

ALKS

Alkermes

$51.48

0.73 (1.44%)

11:19
10/18/17
10/18
11:19
10/18/17
11:19
Hot Stocks
Alkermes says Vivitrol as effective as buprenorphine-naloxone in study »

Alkermes announced that…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 18

    Oct

  • 06

    Nov

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.