uniQure granted patent covering insect cell-based AAV manufacturing technology
uniQure announced that the United States Patent and Trademark Office, or USPTO, has granted a patent for a proprietary invention by uniQure which broadly covers an important component of insect cell-based AAV manufacturing technology. The USPTO issued patent number U.S. 9,708,627, a member of one of uniQure's Hermens patent families, with claims covering the expression of both Rep78 and Rep52 proteins from a Rep78 nucleic acid sequence in insect cells. The newly issued Hermens '627 patent significantly expands uniQure's leading intellectual property portfolio related to large-scale, highly reproducible manufacturing of AAV in insect cells. This patent, which broadens earlier claims granted in this patent family, is based on years of research by uniQure scientists focused on enhancing the genetic stability of the Rep78/52 encoding sequences used to produce AAV vectors in insect cells. The technology covered in the Hermens '627 patent family is currently widely applied in insect cell-based AAV manufacturing.