KemPharm publishes data on intranasal abuse of hydrocodone combination products
KemPharm announced the publication of the results from a study conducted by Inflexxion evaluating the patterns of abuse and how immediate-release hydrocodone acetaminophen combination products are administrated in the peer-reviewed journal Pharmacoepidemiology & Drug Safety. Titled "Patterns of Abuse and Routes of Administration for Immediate-Release Hydrocodone Combination Products," the peer reviewed manuscript examined prevalence of abuse of immediate-release hydrocodone combination products as compared to other classes of opioids. While prescriptions for hydrocodone combination products have recently decreased, they remain the most widely prescribed opioid products in the United States and are subject to frequent abuse among adults and adolescents. Few data existed to understand the contribution of IR products to the problem of prescription opioid abuse. This epidemiological study sought to better understand abuse patterns for IR hydrocodone combination products among adult and adolescent substance abusers. "Our findings suggest that frequently prescribed opioids, such as hydrocodone IR combination products, may contribute substantially to the overall problem of prescription opioid abuse," stated Travis Mickle, Ph.D., president and CEO of KemPharm and co-author. "The data from this study of the epidemiology of abuse of opioids in the United States confirm a prevalence of intranasal abuse of IR hydrocodone combination products among about 23% of adults and 43% of adolescents assessed for substance abuse treatment in the sampled from the Addiction Severity Index - Multimedia Version/ Comprehensive Health Assessment for Teens database. Considering that hydrocodone is the most widely prescribed opioid in the US, these figures translate into a large absolute number of individuals abusing these products intranasally. KemPharm believes this represents a significant public health risk that requires a multimodal mitigation approach, including abuse deterrent technologies."