Asterias enrolls first patient in final cohort of SCiStar trial
Asterias Biotherapeutics announced enrollment and dosing of the first patient in the fifth and final cohort in the company's ongoing SCiStar Phase 1/2a clinical study of AST-OPC1 in motor complete cervical spinal cord injury. This cohort will dose between five and eight patients with AIS-B cervical spinal cord injuries with 20 million AST-OPC1 cells. Asterias has completed enrollment and dosing in four of the five planned SCiStar study cohorts and has enrolled twenty-two patients in the SCiStar study. Twenty-seven patients have been administered AST-OPC1 after including patients from a previous Phase 1 safety trial and results-to-date continue to support the safety of AST-OPC1. In June 2017, Asterias reported 9-month data from the study's second dose cohort. Subjects in this cohort showed meaningful improvements in arm, hand and finger function that were first observed at 3-months after administration of AST-OPC1, and were maintained and further increased at up to 9-months. The company expects multiple safety and efficacy readouts from the SCiStar study during the remainder of 2017 and 2018.