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AGTC

Applied Genetic

$5.00

0.1 (2.04%)

, BIIB

Biogen

$288.74

-0.52 (-0.18%)

07:23
08/10/17
08/10
07:23
08/10/17
07:23

Applied Genetic files IND application with FDA for XLRP product candidate

Applied Genetic (AGTC) announced that it has filed an Investigational New Drug application, or IND, with the FDA to conduct a Phase 1/2 clinical trial of the company's gene therapy product candidate for the treatment of X-linked retinitis pigmentosa, or XLRP, caused by mutations in the RPGR gene. XLRP is an inherited condition that causes progressive vision loss, beginning with night blindness in young boys followed by progressive constriction of the field of vision. Affected men progress to legal blindness by their early forties. Preclinical data indicated that treatment with an investigational gene therapy product slowed the loss of visual function in canines with XLRP caused by mutations in the RPGR gene. XLRP and X-linked retinoschisis, or XLRS, are the two lead development programs within AGTC's collaboration and license agreement with Biogen, Inc. (BIIB), to develop gene-based therapies for multiple ophthalmic diseases. AGTC plans to initiate a clinical study evaluating the safety and efficacy of its proprietary gene therapy for XLRP caused by mutations in the RPGR gene in the United States in the coming months. AGTC is currently scheduling patients for enrollment in clinical trials for XLRS as well as for achromatopsia caused by mutations in the CNGB3 and CNGA3 genes.

AGTC

Applied Genetic

$5.00

0.1 (2.04%)

BIIB

Biogen

$288.74

-0.52 (-0.18%)

  • 15

    Aug

AGTC Applied Genetic
$5.00

0.1 (2.04%)

11/09/16
ROTH
11/09/16
UPGRADE
Target $15
ROTH
Buy
Applied Genetic upgraded to Buy from Neutral at Roth Capital
Roth Capital analyst Joseph Pantginis upgraded Applied Genetic to Buy from Neutral after Q1 results, saying he sees accelerated movement and mindful planning in the clinical programs for XLRS and ACHM, as certain groups from these studies have completed enrollment and patients eligible to participate in future phases of these studies have been vetted. The analyst also raised his price target on the shares to $15 from $12.
02/09/17
BMOC
02/09/17
NO CHANGE
BMOC
Applied Genetic price target lowered to $14 from $20 at BMO Capital
BMO Capital analyst Matthew Luchini lowered his price target on Applied Genetic after the company announced that the Data and Safety Monitoring Committee for the trial of its ACHM-B3 drug had requested additional testing due to observed inter-patient variability in the low-dose cohort. The analyst now believes that the drug has a 33% chance of success, down from 45% previously. However, he keeps an Outperform rating on the shares.
02/09/17
WEDB
02/09/17
NO CHANGE
WEDB
Applied Genetic setback shouldn't hurt drug development, says Wedbush
After Applied Genetic announced that the Data and Safety Monitoring Committee for the trial of its ACHM-B3 drug had requested additional testing due to observed inter-patient variability in the low-dose cohort, Wedbush analyst David Nierengarten does not expect the news to significantly impact the drug's development. He trimmed his price target on the shares to $15 from $17 but keeps an Outperform rating on the stock.
03/15/17
RODM
03/15/17
INITIATION
Target $16
RODM
Buy
Applied Genetic initiated with a Buy at Rodman & Renshaw
Rodman & Renshaw analyst Joseph Pantginis started Applied Genetic Technologies with a Buy rating and $16 price target. The analyst calls the company a leader in adeno-associated virus development.
BIIB Biogen
$288.74

-0.52 (-0.18%)

07/26/17
GSCO
07/26/17
UPGRADE
Target $338
GSCO
Buy
Biogen upgraded to Buy from Neutral at Goldman Sachs
Goldman Sachs analyst Terence Flynn upgraded Biogen following the company's Q2 earnings report and raised his price target for the shares to $338 from $288. The drugmaker closed yesterday down $1.74 to $282.96. Biogen's balance sheet is under-levered, which provides flexibility, while Aducanumab provides Alzheimer's optionality, Flynn tells investors in a research note.
07/26/17
LEER
07/26/17
NO CHANGE
Target $338
LEER
Market Perform
Biogen price target raised to $338 from $304 at Leerink
Leerink analyst Geoffrey Porges raised his price target for Biogen to $338 from $304 after the company reported better than expected Q2 results. While he notes that the Spinraza launch continues to beat expectations, Porges points out that management's cautious commentary about the U.S. market has left investors struggling to forecast the eventual revenue slowdown in the product's trajectory. The analyst reiterates Market Perform rating on the shares.
07/26/17
BERN
07/26/17
NO CHANGE
BERN
All of Biogen's key drugs performed well last quarter, says Bernstein
Bernstein analyst Aaron Gal says that all of Biogen's key drugs had high prescribing rates last quarter. The analyst says that concerns about the company's Spinraza drug are misplaced as it did well last quarter and is getting better coverage from payers. He thinks that opportunities in neurology justify the company's investment in this area. Gal keeps a $310 price target and an Outperform rating on the shares.
07/26/17
07/26/17
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Chipotle (CMG) upgraded to Hold from Underperform at Jefferies with analyst Andy Barish saying the current valuation and consensus estimates "now reflect the reality" of Chipotle's path to recovery. 2. Biogen (BIIB) upgraded to Buy from Neutral at Goldman Sachs with analyst Terence Flynn saying the company's balance sheet is under-levered, which provides flexibility, while Aducanumab provides Alzheimer's optionality. 3. DSW (DSW) upgraded to Outperform from Neutral at Wedbush with the firm saying it is more confident that second quarter results will beat expectations and that the company will reiterate its full-year guidance after conducting checks and speaking with the company. 4. Electronic Arts (EA) upgraded to Buy from Neutral at BofA/Merrill with analyst Justin Post citing a strong fiscal 2019 outlook. 5. Novartis (NVS) upgraded to Overweight from Underweight at Morgan Stanley with analyst Vincent Meunier upgrading the company two notches to Overweight from Underweight following a "massive" reset in consensus expectations. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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CHMI

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NKTR

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VIX

Volatility Index S&P 500 Options

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VGZ

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$NYE

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AVA

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CWBR

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HTBX

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AMNB

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