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AMGN

Amgen

$171.39

1.35 (0.79%)

17:13
08/16/17
08/16
17:13
08/16/17
17:13

Amgen: NEJM publishes results from Repatha cognitive function trial

Amgen announced that the New England Journal of Medicine published results from the Repatha cognitive function trial, which was conducted in a subset of patients enrolled in the randomized, placebo-controlled Repatha cardiovascular outcomes study. The study demonstrated that Repatha was non-inferior to placebo, with no significant difference in cognitive function between the Repatha and placebo-treated groups. "In the first prospectively designed study of cognitive function with a PCSK9 inhibitor using validated instruments, we showed that there were no significant differences between patients taking evolocumab and those on placebo," said Robert P. Giugliano, M.D., S.M., Brigham and Women's Hospital, Boston and lead study investigator. "These findings are reassuring for both physicians and patients because they show that LDL cholesterol levels can be lowered with evolocumab to levels well below current treatment targets, with no negative effects on memory or other cognitive domains." The effect of Repatha on executive function (primary endpoint) was non-inferior to placebo, and there was no statistical difference between Repatha and placebo on the other cognitive domains tested: working memory, memory function and psychomotor speed (secondary endpoints).

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AMGN Amgen
$171.39

1.35 (0.79%)

07/26/17
BMOC
07/26/17
DOWNGRADE
BMOC
Market Perform
Amgen downgraded on valuation lack of near-term catalysts at BMO Capital
As noted earlier, BMO Capital downgraded Amgen to Market Perform from Outperform. Analyst M. Ian Somaiya downgraded the stock based on valuation and his belief that American College of Cardiology guidelines probably won't be updated until late 2018, likely preventing a positive turning point in Repatha sales until 2019. Target $199.
07/26/17
OPCO
07/26/17
NO CHANGE
Target $203
OPCO
Outperform
Amgen price target raised to $203 from $189 at Oppenheimer
Oppenheimer analyst Leah Rush Cann raised her price target for Amgen to $203 from $189 after the company reported "strong" Q2 results. The analyst reiterates an Outperform rating on the shares.
07/26/17
BMOC
07/26/17
DOWNGRADE
BMOC
Market Perform
Amgen downgraded to Market Perform from Outperform at BMO Capital
07/18/17
PIPR
07/18/17
NO CHANGE
Target $14
PIPR
Overweight
Piper says Array deal with Amgen 'another example' of successful partnering
Commenting on Array Biopharma's (ARRY) announcement of a preclinical autoimmune partnership deal with Amgen (AMGN), Piper Jaffray analyst Edward Tenthoff called the agreement "yet another example of Array successfully partnering its discoveries" and raising non-dilutive capital. Tenthoff keeps an Overweight rating and $14 price target on Array Biopharma shares.

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AVEVF

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ZLAB

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OHI

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F

Ford

$11.72

0.09 (0.77%)

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FDX

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$216.00

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EE

El Paso Electric

$54.85

0.05 (0.09%)

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BBBY

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CPRT

Copart

$32.54

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STLD

Steel Dynamics

$33.83

0.03 (0.09%)

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XBKS

Xenith Bankshares

$29.96

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BMY

Bristol-Myers

$62.93

0.23 (0.37%)

17:54
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BBBY

Bed Bath & Beyond

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DESP

Despegar.com

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CBAY

CymaBay

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EVH

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BPL

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RL

Ralph Lauren

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