Argenx: Nature Medicine publishes data on ARGX-116 inhibiting ApoC3
Argenx announced the publication in Nature Medicine of preclinical data on ARGX-116 inhibiting ApoC3, a metabolic target correlated with blood lipid levels, that provide further rationale for the therapeutic potential of anti-ApoC3 SIMPLE AntibodyTM ARGX-116 for the treatment of dyslipidemia. Data published by argenx collaborator Dr. Daniel Rader, M.D. from Staten Biotechnology and the University of Pennsylvania demonstrate that ARGX-116 accelerates ApoC3 clearance and lowers triglyceride-rich lipoproteins in mouse models, signifying a potential protective mechanism. These data could translate to a possible approach to reduce ApoC3 levels and circulating TRL burden in vivo, with therapeutic potential in triglyceride metabolism related diseases like dyslipidemia.