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VTVT

vTv Therapeutics

$5.16

-0.25 (-4.62%)

07:18
09/06/17
09/06
07:18
09/06/17
07:18

vTv Therapeutics, JDRF partner for Phase 2 study of type 1 diabetes treatment

vTv Therapeutics announced that JDRF, the global organization funding type 1 diabetes research, will provide funding to support a Phase 2 Proof of Concept study to explore the effect of vTv Therapeutics' liver-selective glucokinase activator TTP399 as an oral drug for the treatment of T1D. The study is designed to evaluate whether TTP399 is well tolerated when administered as an add-on to insulin therapy for people with T1D and can significantly improve daily glucose profiles and HbA1c. JDRF has committed $3M to the study, and vTv will contribute an equal amount. TTP399 is an orally available GK activator that is designed to target GK activation only in the liver for superior glucose control. In the liver, GK is a key regulator of glucose metabolism, and its activation has been shown to increase glucose utilization, which in turn lowers blood glucose. In a six-month Phase 2b clinical trial of TTP399 in patients with type 2 diabetes, TTP399 demonstrated a statistically significant reduction in HbA1c levels in all TTP399 dose groups compared with placebo. TTP399 was also found to be well-tolerated without increased incidences of hypoglycemia and hyperlipidemia compared to placebo.

VTVT vTv Therapeutics
$5.16

-0.25 (-4.62%)

03/29/17
STFL
03/29/17
NO CHANGE
Target $14
STFL
Buy
vTv Therapeutics TTP399 safety data looked 'very promising,' says Stifel
Stifel analyst Thomas Shrader said the safety data from vTv Therapeutics' Phase 2 trial of TTP399 looked "very promising" and appear to him to be "strong enough" to drive a partnership, which is likely required for the next stages of the drug's development. Shrader keeps a Buy rating and $14 price target on vTv shares.
12/15/16
STFL
12/15/16
NO CHANGE
STFL
vTv Therapeutics price target raised to $14 from $12 at Stifel
Stifel analyst Thomas Shrader believes that vTv's TTP273 showed positive results in a Phase IIb trial of T2d patients. The analyst thinks that the drug " has demonstrated proof of concept with hints of an improved safety profile relative to Byetta." He predicts that vTv will obtain a partner for the drug and will receive " a $100M - $200M upfront payment and low double digit royalties on sales." Shrader keeps a Buy rating on the shares.
12/15/16
HCWC
12/15/16
NO CHANGE
Target $13
HCWC
Buy
vTv Therapeutics Phase 2 diabetes data a 'big win,' says H.C. Wainwright
H.C. Wainwright analyst Corey Davis views vTv Therapeutics' (VTVT) data from its Phase 2 study of TTP273 in type-2 diabetes as "very positive" and a "big win." Efficacy is close to Novo Nordisk's (NVO) oral semaglutide, Davis tells investors in a research note. vTv is "highly likely" to succeed in finding a partner given the attractiveness of the diabetes market and the differentiated profile '273 has now created, the analyst contends. Davis keeps a Buy rating on the shares with a $13 price target.
09/26/16
HCWC
09/26/16
INITIATION
Target $13
HCWC
Buy
vTv Therapeutics initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Corey Davis started vTv Therapeutics with a Buy rating and $13 price target.

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