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CBIO

Catalyst Biosciences

$3.39

0.07 (2.11%)

08:09
09/06/17
09/06
08:09
09/06/17
08:09

Catalyst Biosciences reports data from Phase 1/2 trial for hemophilia B

Catalyst Biosciences announced positive clinical data from the first Cohort of its ongoing Phase 1/2 proof-of-concept clinical trial in individuals with severe hemophilia B. Cohort 1 results demonstrate that an intravenous dose of CB 2679d is approximately 22 times more potent than an intravenous dose of BeneFIX as measured by activity levels using a one-stage clotting assay; and the average time that CB 2679d stayed in the circulation was significantly longer at 34 hours compared with BeneFIX at 25 hours. These potency results "support that CB 2679d has the potency advantage needed to be delivered as a convenient subcutaneous prophylactic therapy to prevent spontaneous bleeding in individuals with Hemophilia B". The clinical trial will document the subcutaneous bioavailability and clotting ability of CB 2679d achieved with single intravenous and subcutaneous dosing cohorts, followed by daily subcutaneous injections of CB 2679d in the fifth cohort. Interim, top-line results of this open-label study are expected by the end of 2017 and complete trial results in early 2018.

  • 26

    Sep

CBIO Catalyst Biosciences
$3.39

0.07 (2.11%)

06/12/17
06/12/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. United Technologies (UTX) initiated with a Hold at HSBC. 2. Catalyst Biosciences (CBIO) initiated with a Buy at Chardan. 3. Xoma (XOMA) initiated with a Buy at H.C. Wainwright. 4. Solaris Oilfield (SOI) initiated with a Buy at Seaport Global. 5. Camping World (CWH) coverage resumed with a Buy at BofA/Merrill. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
06/12/17
CHDN
06/12/17
INITIATION
Target $10
CHDN
Buy
Catalyst Biosciences initiated with a Buy at Chardan
Chardan analyst Madhu Kumar initiated Catalyst Biosciences with a Buy and a $10 price target saying saying its two lead assets, engineered activated factor VII, FVIIa, marzeptacog alfa, MarzAA, for hemophilia with inhibitors; and engineered factor IX, FIX, CB 2679d, for hemophilia B, have significant potential to disrupt the hemophilia therapy landscape and believes the market potential is substantial. The phase II/III trial for MarzAA is expected to start in 4Q 2017, while phase I/II studies for CB 2679d are expected to start in 2Q 2017.
06/06/17
LTCO
06/06/17
INITIATION
Target $11
LTCO
Buy
Catalyst Biosciences initiated with a Buy at Ladenburg
Ladenburg Thalmann analyst Kevin DeGeeter started Catalyst Biosciences with a Buy rating and $11 price target. The analyst views the company as an "emerging hematology story with a unique approach to address a central question for hemophilia treatment."

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