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PFNX

Pfenex

$3.18

0.03 (0.95%)

, LLY

Eli Lilly

$83.99

-0.02 (-0.02%)

07:17
11/10/17
11/10
07:17
11/10/17
07:17

Pfenex announces interim pharmacokinetic results from Study PF708-301

Las night, Pfenex (PFNX) announced interim pharmacokinetic results from ongoing Study PF708-301, which compares the effects of PF708 and Forteo in osteoporosis patients. PF708 is a teriparatide product candidate that is being developed through the 505(b)(2) regulatory pathway in the US and references Forteo, marketed by Eli Lilly (LLY) for the treatment of osteoporosis patients at a high risk of fracture, as the Reference Listed Drug. Study PF708-301 completed enrollment in the third quarter of 2017 with a total of 181 patients - 90 randomized to PF708 and 91 to Forteo. The primary study endpoint is anti-drug antibody formation after 24 weeks of drug treatment. The secondary study endpoints are changes in bone mineral density and bone turnover markers after 24 weeks of drug treatment, as well as PK parameters for up to 4 hours after the first dose. The PF708 and Forteo PK profiles are comparable, and there are no statistically significant differences in key PK parameters. The study is on-track for completion and top-line immunogenicity data readout in the first half of 2018. Pfenex believes that results from Study PF708-301, along with the previously-announced bioequivalence findings from Study PF708-101 in healthy subjects, should satisfy the clinical filing requirements for PF708 and expects to submit the new drug application to the FDA in the third quarter of 2018. Pfenex believes it has sufficient cash resources to fund all necessary activities leading up to and including the submission of the NDA to the FDA.

PFNX

Pfenex

$3.18

0.03 (0.95%)

LLY

Eli Lilly

$83.99

-0.02 (-0.02%)

PFNX Pfenex
$3.18

0.03 (0.95%)

05/08/17
05/08/17
NO CHANGE

Pfenex reports Q1 EPS (43c), consensus (55c)
Reports Q1 revenue $2.8M, consensus $3M.
01/25/17
JMPS
01/25/17
NO CHANGE
JMPS
Conduct of former Pfenex CEO unlikely to affect results, says JMP Securities
After Pfenex announced that its CEO had resigned amid allegations of improper conduct involving procedures for third party contracts, JMP Securities analyst Jason Butler, after speaking with the company ,does not expect its past or future financial results to be affected by the former CEO's conduct. He remains confident in the company's management and keeps a $21 price target and an Outperform rating on the shares.
LLY Eli Lilly
$83.99

-0.02 (-0.02%)

10/24/17
PIPR
10/24/17
NO CHANGE
Target $107
PIPR
Overweight
Eli Lilly Humalog fears overblown, says Piper Jaffray
Piper Jaffray analyst Richard Purkiss attributes Eli Lilly's (LLY) post-earnings decline to further anxiety around price competition in the U.S. diabetes segment after the company said on its earnings call that it will not challenge Sanofi's (SNY) biosimilar for Humalog. However, he sees these concerns as substantially overdone, pointing to the 39% year-over-year growth reported in Q3 for the diabetes franchise, and view today's pullback as a clear buying opportunity. Purkiss keeps an Overweight rating on Eli Lilly and raised his price target on the stock to $107 from $105.
10/18/17
SBSH
10/18/17
UPGRADE
Target $72
SBSH
Buy
Merck upgraded to Buy from Neutral at Citi
Citi analyst Andrew Baum upgraded Merck (MRK) to Buy and raised his price target for the shares to $72 from $65. The healthcare giant closed yesterday down 12c to $63.22. While Merck's non-Keytruda business continues to erode, the market is undervaluing both the ultimate patient derived xenograft market size and Merck's likely market share with Keytruda, Baum tells investors in a research note. The analyst revised his initial PDx market estimates of $35bn to at least $50bn and increased his 2025 Keytruda forecasts from $9B to$15B. The analyst prefers Eli Lilly (LLY), Bristol-Myers (BMY) and Merck among the U.S. pharmaceutical majors. He also downgraded Roche (RHHBY) this morning to Neutral.
10/16/17
JEFF
10/16/17
NO CHANGE
Target $115
JEFF
Buy
Jefferies ups price target on top global pick AbbVie to $115
Jefferies analyst Jeffrey Holford keeps AbbVie (ABBV) as his top global Pharmaceuticals pick for October, followed by Roche (RHHBY), Novartis (NVS), Bayer (BAYRY), Johnson & Johnson (JNJ), Eli Lilly (LLY) and GlaxoSmithKline (GSK). The analyst raised his price target for AbbVie shares to $115 from $107 and keeps a Buy rating on the name. Among his other target changes include bumping Eli Lilly's to $100 from $96.
10/10/17
10/10/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. HSBC (HSBC) downgraded to Underperform from Neutral at Credit Suisse with analyst Sanjay Jain citing valuation. 2. Jabil Circuit (JBL) downgraded to Sell from Neutral at Goldman Sachs with analyst Mark Delaney saying street expectations, which assume Jabil's earnings grow double digits year-over-year for both of the next two years, are overly optimistic. 3. Carlyle Group (CG) downgraded to Neutral from Buy at Citi with analyst William Katz citing valuation with the shares up 60% year-to-date. 4. Eli Lilly (LLY) downgraded to Neutral from Outperform at Credit Suisse with analyst Vamil Divan saying the valuation looks full with the shares up 13% since mid-August. 5. Ralph Lauren (RL) downgraded to Sell from Hold at Miller Tabak. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

10:30
11/23/17
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General news
FX Action: EUR-USD, USD-JPY and other major pairings are in sideways mode »

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DE

Deere

$145.25

6.02 (4.32%)

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TSLA

Tesla

$312.60

-5.21 (-1.64%)

08:08
11/23/17
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Tesla CEO highlights 'record time' on Australian ion battery »

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  • 16

    Jan

TSLA

Tesla

$312.60

-5.21 (-1.64%)

08:07
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Tesla completes construction on largest lithium ion battery in Australia »

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  • 16

    Jan

GSK

GlaxoSmithKline

$35.06

0.25 (0.72%)

, INVA

Innoviva

$13.42

0.01 (0.07%)

07:56
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Hot Stocks
GSK, Innoviva submit data to FDA for expanded Trelegy Ellipta label »

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GSK

GlaxoSmithKline

$35.06

0.25 (0.72%)

INVA

Innoviva

$13.42

0.01 (0.07%)

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SVM

Silvercorp Metals

$2.51

-0.07 (-2.71%)

07:52
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07:52
Hot Stocks
Silvercorp Metals to buy back up to 5% of shares »

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CEL

Cellcom Israel

$10.00

-0.1 (-0.99%)

07:49
11/23/17
11/23
07:49
11/23/17
07:49
Hot Stocks
Cellcom Israel now second layer company according to Concentration Law »

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GASS

StealthGas

$4.07

0.36 (9.70%)

07:06
11/23/17
11/23
07:06
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07:06
Recommendations
StealthGas analyst commentary at Jefferies »

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CPRT

Copart

$41.01

4.31 (11.74%)

07:02
11/23/17
11/23
07:02
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07:02
Recommendations
Copart analyst commentary at Jefferies »

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  • 19

    Dec

DE

Deere

$145.25

6.02 (4.32%)

06:56
11/23/17
11/23
06:56
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06:56
Upgrade
Deere rating change at Deutsche Bank »

Deere upgraded to Buy…

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  • 28

    Nov

DE

Deere

$145.25

6.02 (4.32%)

06:55
11/23/17
11/23
06:55
11/23/17
06:55
Recommendations
Deere analyst commentary at Wells Fargo »

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  • 28

    Nov

06:40
11/23/17
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06:40
General news
FX Update: The dollar has remained on a weakening track »

FX Update: The dollar has…

SECO

Seeco Holding

$8.34

0.14 (1.71%)

04:55
11/23/17
11/23
04:55
11/23/17
04:55
Conference/Events
Seeco Holding management to meet with Jefferies »

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  • 23

    Nov

04:55
11/23/17
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04:55
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Conference/Events
Deutsche Bank to hold a conference »

Thailand SET Corporate…

04:55
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Conference/Events
RBC Capital to hold field trip »

European Utilities Field…

BASFY

BASF

$27.39

-0.13 (-0.47%)

04:55
11/23/17
11/23
04:55
11/23/17
04:55
Conference/Events
BASF management to meet with Evercore ISI »

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  • 23

    Nov

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    Nov

RBS

RBS

$7.30

-0.04 (-0.54%)

04:55
11/23/17
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04:55
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04:55
Conference/Events
RBS management to meet with Jefferies »

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  • 23

    Nov

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04:25
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General news
FX Action: USD-CAD punched out a 10-day low »

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02:35
11/23/17
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General news
FX Update: The dollar has remained on a downward path »

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L

Loews

$49.36

-0.02 (-0.04%)

, GE

General Electric

$18.15

0.32 (1.79%)

18:41
11/22/17
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18:41
Hot Stocks
Loews CEO James Tisch buys 3M shares of General Electric »

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L

Loews

$49.36

-0.02 (-0.04%)

GE

General Electric

$18.15

0.32 (1.79%)

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BRFS

BRF S.A.

$12.77

-0.16 (-1.24%)

18:06
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Hot Stocks
BRF S.A. names Jose Aurelio Drummond Jr. as CEO »

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SU

Suncor

$35.42

0.2 (0.57%)

18:02
11/22/17
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Hot Stocks
Suncor closes sale of equity interest in East Tan Farm, redeems $750M in debt »

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  • 05

    Dec

SAP

SAP

$113.85

-1.44 (-1.25%)

17:53
11/22/17
11/22
17:53
11/22/17
17:53
Periodicals
SAP launches investigation of sales practices in Gulf region, Reuters reports »

SAP has launched a formal…

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