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FATE

Fate Therapeutics

$4.44

-0.15 (-3.27%)

08:04
11/10/17
11/10
08:04
11/10/17
08:04

Fate Therapeutics: Subject in dose 2 cohort achieves mLFS at day 14 in study

Fate Therapeutics announced initial clinical data from the ongoing VOYAGE Phase 1 study of FATE-NK100 as a monotherapy for the treatment of refractory or relapsed acute myelogenous leukemia. The data were presented today in a poster session at the Society for Immunotherapy of Cancer 2017 Annual Meeting in National Harbor, Maryland. Anti-leukemia activity was observed with FATE-NK100, the company's first-in-class adaptive memory natural killer cell cancer immunotherapy, in each of the treated dose cohorts of the VOYAGE study. The subject in the second dose cohort achieved a morphologic leukemia-free state following a single intravenous infusion of FATE-NK100 as a monotherapy. Prior to treatment, the subject presented in relapse, was refractory to conventional NK cell therapy and had 50% leukemic blasts in the bone marrow. At Day 14 following treatment, a bone marrow biopsy showed clearance of leukemic blasts in the marrow, and approximately 3x104 FATE-NK100 cells per mL were measured in the peripheral blood. The subject in the first dose cohort of VOYAGE presented in primary induction failure with 87% leukemic blasts in the bone marrow. Two weeks following a single infusion of FATE-NK100, a bone marrow biopsy revealed a nearly 50% reduction in leukemic blasts. In addition, approximately 76% of NK cells in the peripheral blood were of FATE-NK100 origin. The accelerated dose-escalation design of VOYAGE is designed to evaluate the safety and determine the maximum dose of a single intravenous infusion of FATE-NK100 as a monotherapy. The three dose levels are 1x10, 2x10 and up to 1x10 adjusted to kg of body weight. FATE-NK100 has now advanced through the first two dose cohorts with no reports of dose limiting toxicities The third dose cohort is currently enrolling. A ten-subject expansion cohort is expected to be enrolled at the maximum dose level.

  • 28

    Nov

  • 09

    Dec

FATE Fate Therapeutics
$4.44

-0.15 (-3.27%)

09/08/17
LEER
09/08/17
INITIATION
Target $7
LEER
Outperform
Fate Therapeutics resumed with an Outperform at Leerink
Leerink analyst Michael Schmidt resumed coverage of Fate Therapeutics with an Outperform rating and $7 price target. The analyst believes Fate has generated a "compelling" platform and pipeline with "significant potential" to disrupt the cellular immunotherapy space.
09/08/17
09/08/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. DowDuPont (DWDP) initiated with a Top Pick at RBC Capital. 2. Electronic Arts (EA) was initiated with a Conviction Buy while Activision Blizzard (ATVI) was initiated with a Neutral at Goldman Sachs. 3. AB InBev (BUD) initiated with a Buy at Argus. 4. LivaNova (LIVN) initiated with a Buy at Jefferies. 5. Fate Therapeutics (FATE) resumed with an Outperform at Leerink. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
10/12/17
HCWC
10/12/17
INITIATION
Target $7
HCWC
Buy
Fate Therapeutics assumed with a Buy at H.C. Wainwright
H.C. Wainwright analyst Edward White assumed coverage of Fate Therapeutics with a Buy rating and $7 price target. The analyst projects revenues of $329M and $68M for ProTmune and NK-100, respectively, in 2026.

TODAY'S FREE FLY STORIES

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IBM

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GE

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TWX

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, T

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TPIC

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SYNA

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MKSI

MKS Instruments

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$1.18

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