Amgen: STRIVE results show significant reduction in mean monthly migraine days
Amgen announced that the New England Journal of Medicine published positive results from the six-month Phase 3 STRIVE study evaluating Aimovig versus placebo for the prevention of episodic migraine. Aimovig delivered clinically meaningful and statistically significant differences from placebo for all primary and secondary endpoints in the study. Patients taking Aimovig experienced a significant reduction in mean monthly migraine days and were significantly more likely to achieve a 50 percent or greater reduction in monthly migraine days than those taking placebo. Patients reported significant improvements on key measures assessing the impact of migraine on their lives when taking Aimovig, based on the Migraine Physical Function Impact Diary - a novel patient-reported outcomes instrument validated to specifically measure the impact of migraine on physical functioning. Aimovig is the first and only fully human monoclonal antibody designed to specifically block the calcitonin gene-related peptide receptor; CGRP plays a critical role in migraine activation. "STRIVE is the first fully reported Phase 3 study of the CGRP pathway monoclonal antibodies, and it clearly shows that blocking this pathway can reduce the impact of migraine," said Peter Goadsby, M.D., Ph.D., FAHS, director, NIHR-Wellcome Trust King's Clinical Research Facility and professor of Neurology, King's College Hospital, London. "The results of STRIVE represent a real transition for migraine patients from poorly understood, repurposed treatments, to a specific migraine-designed therapy. STRIVE, as with the monoclonal antibody developments generally, represents an incredibly important step forward for migraine understanding and migraine treatment."