Breaking News Instant updates and real-time market news.

SAGE

Sage Therapeutics

$91.90

2.11 (2.35%)

06:03
12/07/17
12/07
06:03
12/07/17
06:03

Sage Therapeutics reports 'positive' results from Phase 2 trial of SAGE-217

Sage Therapeutics announced positive top-line results from the Phase 2, double-blind, placebo-controlled clinical trial of SAGE-217 in the treatment of 89 adult patients with moderate to severe major depressive disorder. In the trial, treatment for 14 days with SAGE-217 was associated with a statistically significant mean reduction in the Hamilton Rating Scale for Depression 17-Item total score from baseline to Day 15 (the time of the primary endpoint) of 17.6 points for SAGE-217, compared to 10.7 for placebo (pless than0.0001). Statistically significant improvements were observed in the HAM-D compared to placebo by the morning following the first dose through Week 4 and the effects of SAGE-217 remained numerically greater than placebo through the end of follow-up at Week 6. At Day 15, 64 percent of patients who received SAGE-217 achieved remission, defined as a score of 7 or less on the HAM-D scale, compared with 23 percent of patients who received placebo (p=0.0005). Other secondary endpoints were all similarly highly significant at Day 15 (pless than or equal to0.002). SAGE-217 was generally well-tolerated with no serious or severe adverse events; the most common adverse events in the SAGE-217 group were headache, dizziness, nausea, and somnolence. A low rate of discontinuations due to AEs was reported; overall reports of AEs were similar between drug (53%) and placebo (46%), with a safety profile consistent with that seen in earlier trials. SAGE-217 was granted Fast Track Designation by the U.S. FDA in May 2017.

SAGE Sage Therapeutics
$91.90

2.11 (2.35%)

11/10/17
NEED
11/10/17
NO CHANGE
Target $100
NEED
Buy
Sage Therapeutics price target raised to $100 from $86 at Needham
Needham analyst Danielle Brill raised her price target on Sage Therapeutics to $100 and kept her Buy rating. Brill cites the company's IV brexanolone Phase 3 trials in moderate and severe postpartum depression achieving primary efficacy endpoints, saying that while she had modest expectations for overall commercial opportunity w/ brexanolone, the drug does highlight an unmed need as the first treatment approved for PPD. The analyst adds that there is also significant upside opportunity for Sage shares w/ Phase 2 MDD data reporting expected out by year-end.
11/15/17
RHCO
11/15/17
NO CHANGE
Target $116
RHCO
Buy
Sage Therapeutics price target raised to $116 from $82 at SunTrust
SunTrust analyst Edward Nash raised his price target on Sage Therapeutics to $116 based on the recent positive top-line data from both Phase III trials for brexanolone in post-partum depression. Nash says he has increased his probability of success estimate for the treatment to 80% from 70%, with the remaining 20% based on regulatory risk. The analyst also adjusted his projections for the drug efficacy in Major Depressive Disorder, keeping his Buy rating on Sage Therapeutics.
11/17/17
BMOC
11/17/17
NO CHANGE
Target $112
BMOC
Outperform
Sage Therapeutics price target raised to $112 from $80 at BMO Capital
BMO Capital analyst Gary Nachman raised his price target for Sage Therapeutics to $112 saying he received "very positive" feedback from two leading psychiatrists on the brexanolone Phase 3 data in both severe and moderate postpartum depression. The shares closed yesterday up 20c to $85.67. The physicians are "very impressed" by the rapid onset and good safety profile for brexanolone and expect to use the drug a lot, Nachman tells investors in a research note. The psychiatrists also expressed their belief in a high probability of success for the upcoming SAGE-217 data in postpartum depression and major depressive disorder, the analyst adds. He sees a good risk/reward into those catalysts at current share levels. Nachman reiterates an Outperform rating on Sage.
11/27/17
RBCM
11/27/17
NO CHANGE
Target $137
RBCM
Outperform
Sage Therapeutics price target lowered to $137 from $145 at RBC Capital
RBC Capital analyst Brian Abrahams lowered his price target on Sage Therapeutics to $137 from $145, modelling a 40% probability of success and the possibility of more non-responders in the Phase 2B SAGE-217 for major depressive disorder - MDD - treatment. Abrahams keeps Outperform rating, saying the risk-reward profile is still attractive given the likelihood of "many additional shots on goal even if MDD fails", as negative outcome would not necessarily impact the overall prospects of the oral program in post-partum depression.

TODAY'S FREE FLY STORIES

WEI

Weidai

$0.00

(0.00%)

20:33
11/14/18
11/14
20:33
11/14/18
20:33
Syndicate
Weidai 4.5M share IPO priced at $10.00 »

The deal was priced at…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

CPB

Campbell Soup

$39.16

-0.1 (-0.25%)

20:31
11/14/18
11/14
20:31
11/14/18
20:31
Hot Stocks
Campbell Soup responds to ISS regarding board elections »

Campbell Soup issued the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 20

    Nov

CRM

Salesforce

$129.25

-2.93 (-2.22%)

20:25
11/14/18
11/14
20:25
11/14/18
20:25
Periodicals
Breaking Periodicals news story on Salesforce »

Salesforce to accommodate…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 19

    Nov

  • 20

    Nov

  • 27

    Nov

  • 27

    Nov

  • 28

    Nov

  • 29

    Nov

  • 06

    Dec

  • 11

    Dec

  • 03

    Mar

WMT

Walmart

$101.58

-1.37 (-1.33%)

, JCP

J.C. Penney

$1.23

-0.05 (-3.91%)

20:25
11/14/18
11/14
20:25
11/14/18
20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

WMT

Walmart

$101.58

-1.37 (-1.33%)

JCP

J.C. Penney

$1.23

-0.05 (-3.91%)

BERY

Berry Global

$45.91

-0.49 (-1.06%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

  • 15

    Nov

  • 15

    Nov

BHVN

Biohaven Pharmaceutical

$33.70

-3.18 (-8.62%)

19:53
11/14/18
11/14
19:53
11/14/18
19:53
Recommendations
Biohaven Pharmaceutical analyst commentary  »

Biohaven Pharmaceutical…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 14

    Nov

  • 15

    Nov

  • 27

    Nov

LOXO

Loxo Oncology

$143.69

-15.62 (-9.80%)

19:51
11/14/18
11/14
19:51
11/14/18
19:51
Initiation
Loxo Oncology initiated  »

Loxo Oncology initiated…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 15

    Nov

  • 26

    Nov

  • 27

    Nov

OCUL

Ocular Therapeutix

$5.06

-0.25 (-4.71%)

19:50
11/14/18
11/14
19:50
11/14/18
19:50
Initiation
Ocular Therapeutix initiated  »

Ocular Therapeutix…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 27

    Nov

  • 28

    Dec

VYGR

Voyager Therapeutics

$11.25

-0.54 (-4.58%)

19:49
11/14/18
11/14
19:49
11/14/18
19:49
Upgrade
Voyager Therapeutics rating change  »

Voyager Therapeutics…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

GLPG

Galapagos NV

$103.79

1.03 (1.00%)

19:48
11/14/18
11/14
19:48
11/14/18
19:48
Initiation
Galapagos NV initiated  »

Galapagos NV initiated…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

COPY

CopyTele

$0.00

(0.00%)

19:47
11/14/18
11/14
19:47
11/14/18
19:47
Upgrade
CopyTele rating change  »

CopyTele upgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

VICI

VICI Properties

$21.43

-0.04 (-0.19%)

19:40
11/14/18
11/14
19:40
11/14/18
19:40
Syndicate
VICI Properties 30M share Secondary priced at $21.00 »

The deal size was…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

WHD

Cactus

$32.37

-0.7 (-2.12%)

19:37
11/14/18
11/14
19:37
11/14/18
19:37
Hot Stocks
Cactus names Stephen Tadlock new CFO »

Cactus announced that the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

RVLT

Revolution Lighting

$1.42

(0.00%)

19:32
11/14/18
11/14
19:32
11/14/18
19:32
Hot Stocks
Revolution Lighting receives revised $1.50 per share proposal from RVL LLC »

Revolution Lighting…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

GE

General Electric

$8.34

-0.265 (-3.08%)

19:20
11/14/18
11/14
19:20
11/14/18
19:20
Periodicals
General Electric withdraws from Nigeria rail concession, Reuters says »

GE has withdrawn from a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

BCSF

Bain Capital Specialty Finance

$0.00

(0.00%)

19:11
11/14/18
11/14
19:11
11/14/18
19:11
Syndicate
Bain Capital Specialty Finance 7.5M share IPO price $20.25 »

The deal priced at the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

TSLA

Tesla

$344.07

5.36 (1.58%)

19:07
11/14/18
11/14
19:07
11/14/18
19:07
Periodicals
Tesla Model 3 owners experience issues in cold weather, Electrek says »

Tesla Model 3 will face…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 19

    Nov

  • 19

    Nov

  • 13

    Dec

NGHC

National General

$24.75

-3.05 (-10.97%)

19:05
11/14/18
11/14
19:05
11/14/18
19:05
Syndicate
National General 5M share Secondary priced at $24.00 »

JPMorgan, Goldman Sachs…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 28

    Nov

  • 03

    Dec

  • 04

    Dec

  • 15

    Nov

WMT

Walmart

$101.58

-1.37 (-1.33%)

19:01
11/14/18
11/14
19:01
11/14/18
19:01
Periodicals
Walmart's Cornershop to expand into Canada next year, Reuters says »

Cornershop, a Latin…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

WUBA

58.com

$60.54

1.65 (2.80%)

, CSCO

Cisco

$44.35

-0.78 (-1.73%)

18:54
11/14/18
11/14
18:54
11/14/18
18:54
Hot Stocks
Fly Intel: After Hours Movers »

UP AFTER EARNINGS: 58.com…

WUBA

58.com

$60.54

1.65 (2.80%)

CSCO

Cisco

$44.35

-0.78 (-1.73%)

VIPS

Vipshop

$5.35

0.105 (2.00%)

SFS

Smart & Final Stores

$4.96

-0.2 (-3.88%)

NTES

NetEase

$219.69

5.51 (2.57%)

SVMK

SurveyMonkey

$12.78

1.455 (12.85%)

ORCL

Oracle

$48.84

-0.68 (-1.37%)

WP

Worldpay

$82.71

-2.74 (-3.21%)

CDTI

CDTi

$1.49

-0.03 (-1.97%)

APVO

Aptevo Therapeutics

$3.13

-0.09 (-2.80%)

NTAP

NetApp

$78.05

-0.85 (-1.08%)

HSDT

Helius Medical

$9.20

-0.57 (-5.83%)

MGI

MoneyGram

$2.14

-0.09 (-4.04%)

CASI

Casi Pharmaceuticals

$3.33

0.025 (0.76%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 15

    Nov

  • 15

    Nov

  • 15

    Nov

  • 15

    Nov

  • 26

    Nov

  • 27

    Nov

  • 05

    Dec

  • 06

    Dec

  • 10

    Dec

  • 10

    Jan

  • 15

    Nov

ECOL

US Ecology

$69.90

0.06 (0.09%)

18:48
11/14/18
11/14
18:48
11/14/18
18:48
Earnings
US Ecology backs FY18 adj. EPS view $2.28-$2.44, consensus $2.35 

:

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

ECOL

US Ecology

$69.90

0.06 (0.09%)

18:47
11/14/18
11/14
18:47
11/14/18
18:47
Hot Stocks
US Ecology purchases Ecoserv Industrial Disposal »

US Ecology has acquired…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

FB

Facebook

$144.25

2.06 (1.45%)

18:36
11/14/18
11/14
18:36
11/14/18
18:36
Periodicals
Facebook execs aimed to hide election meddling, propaganda on platform, NYT says »

Facebook CEO Mark…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 28

    Nov

SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$270.19

-1.81 (-0.67%)

18:22
11/14/18
11/14
18:22
11/14/18
18:22
Periodicals
China delivers written response to U.S. trade reform demands, Reuters says »

China has sent a written…

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$270.19

-1.81 (-0.67%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

OI

Owens-Illinois

$17.50

0.74 (4.42%)

18:18
11/14/18
11/14
18:18
11/14/18
18:18
Earnings
Owens-Illinois sees FY19 EPS growth of over 10% »

Sees FY19: Segment…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

CPA

Copa Holdings

$81.37

1.43 (1.79%)

18:12
11/14/18
11/14
18:12
11/14/18
18:12
Earnings
Copa Holdings reports Q3 EPS $1.36, consensus $1.43 »

Reports Q3 revenue…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.