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KURA

Kura Oncology

$14.90

0.75 (5.30%)

10:07
12/11/17
12/11
10:07
12/11/17
10:07

Kura Oncology findings supoort tipifarnib development in bone marrow cancers

Kura Oncology reported new findings supporting the development of lead candidate tipifarnib, a potent and selective inhibitor of farnesyl transferase, in the treatment of certain bone marrow cancers. These results were featured in presentations at the American Society of Hematology Annual Meeting and Exposition in Atlanta. Among the findings presented at ASH were the identification of CXCR4/CXCR2 expression ratio and bone marrow homing of myeloid cells as potential biomarkers of tipifarnib activity across the bone marrow cancers, myelodysplastic syndromes, acute myeloid leukemia and chronic myelomonocytic leukemia, further showing that the CXCL12/CXCR4 pathway is a potential therapeutic target of farnesyl transferase inhibitors. Previously, Kura Oncology reported preliminary results from an ongoing Phase 2 clinical trial of tipifarnib in patients with peripheral T-cell lymphoma identifying the CXCL12/CXCR4 pathway as a potential target of tipifarnib. Specifically, high levels of CXCL12 gene expression and absence of single nucleotide gene variations in the 3'-untranslated region of the CXCL12 gene were associated with observed clinical activity of tipifarnib in these PTCL patients. In the ASH presentation entitled, "The CXCL12/CXCR4 Pathway As a Potential Target of Tipifarnib: Preliminary Results from an Open-Label, Phase II Study in Relapsed or Refractory Peripheral T-Cell Lymphoma," Kura Oncology extends these observations and provides data supporting the observed tipifarnib-derived clinical benefit for the CXCL12-positive population. In the ASH presentation entitled, "The CXCL12/CXCR4 Pathway As a Potential Target of Tipifarnib in Acute Myeloid Leukemia and Myelodysplastic Syndromes," Kura Oncology presented results that identify the ratio of CXCR4/CXCR2 gene expression and bone marrow homing of myeloid cells as potential biomarkers of the activity of tipifarnib in certain bone marrow tumors. The results were obtained by analyzing data from previous studies of tipifarnib in AML and MDS, as well as data from the ongoing Phase 2 clinical trial of tipifarnib in CMML.

KURA Kura Oncology
$14.90

0.75 (5.30%)

08/08/17
SBSH
08/08/17
NO CHANGE
Target $13
SBSH
Buy
Kura Oncology Phase 2 trial update 'encouraging,' says Citi
Citi analyst Joel Beatty views Kura Oncology's Phase 2 HRAS mutant SCCHN trial update as "encouraging." Though the number of patients is still small, the 60% partial response rate is higher than the 13%-16% rate seen historically with approved agents in the squamous cell carcinomas of the head and neck setting, Beatty tells investors in a research note. He raised his price target for Kura shares to $13 from $12 and keeps a Buy rating on the name.
09/07/17
COWN
09/07/17
INITIATION
COWN
Outperform
Kura Oncology initiated with an Outperform at Cowen
Cowen analyst Chris Shibutani initiated Kura Oncology with an Outperform saying its uniquely positioned to generate significant value from its precision based approach to developing its lead compound, tipifarnib. The analyst said recent clinical data increases confidence in tipifarnib's opportunity in HRAS-mutan SCCHN, with additional opportunity in PTCL. Shibutani sees a commercial peak sales of $600M+ for these orphan oncology indications.
11/09/17
SBSH
11/09/17
NO CHANGE
Target $19
SBSH
Buy
Kura Oncology price target raised to $19 from $15 at Citi
Citi analyst Joel Beatty raised his price target for Kura Oncology to $19 ahead of next week's investor meeting and keeps a Buy rating on the shares. The analyst believes the data to date for Tipifarnib in HRAS-mutant head and neck squamous cell carcinoma suggests it could be superior to the 13%-16% response rate typically seen with the standard of care.

TODAY'S FREE FLY STORIES

KORS

Michael Kors

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0.25 (0.37%)

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0.59 (0.62%)

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KHC

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$57.78

0.72 (1.26%)

, QCOM

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KHC

Kraft Heinz

$57.78

0.72 (1.26%)

QCOM

Qualcomm

$59.95

0.85 (1.44%)

MRK

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$59.08

-0.03 (-0.05%)

TGT

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$71.22

0.28 (0.39%)

OMC

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$71.98

-0.1 (-0.14%)

CCL

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0.12 (0.19%)

JNJ

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0.06 (0.05%)

MMM

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LLY

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VLO

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$118.81

-3.06 (-2.51%)

EMR

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$72.50

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WBA

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$63.52

0.09 (0.14%)

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MU

Micron

$61.33

-0.15 (-0.24%)

10:48
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ATUS

Altice USA

$18.50

-0.05 (-0.27%)

10:40
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MU

Micron

$61.33

-0.15 (-0.24%)

, XLNX

Xilinx

$69.63

0.88 (1.28%)

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MU

Micron

$61.33

-0.15 (-0.24%)

XLNX

Xilinx

$69.63

0.88 (1.28%)

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ZTCOY

ZTE Corp.

$0.00

(0.00%)

, DDAIF

Daimler AG

$0.00

(0.00%)

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ZTCOY

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$0.00

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DDAIF

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$0.00

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FCAU

Fiat Chrysler

$21.82

-0.445 (-2.00%)

HMC

Honda

$32.04

-0.34 (-1.05%)

NSANY

Nissan

$0.00

(0.00%)

F

Ford

$11.51

-0.11 (-0.95%)

GM

General Motors

$38.30

-0.09 (-0.23%)

TM

Toyota

$129.97

-2.47 (-1.87%)

VLKAY

Volkswagen

$0.00

(0.00%)

BAC

Bank of America

$30.16

-0.03 (-0.10%)

C

Citi

$68.42

-0.86 (-1.24%)

GS

Goldman Sachs

$235.05

-1.1 (-0.47%)

JPM

JPMorgan

$110.62

-0.64 (-0.58%)

MS

Morgan Stanley

$53.02

-0.96 (-1.78%)

USB

U.S. Bancorp

$50.54

-0.14 (-0.28%)

WFC

Wells Fargo

$54.91

0.25 (0.46%)

TWTR

Twitter

$33.64

0.11 (0.33%)

AA

Alcoa

$47.92

-1.26 (-2.56%)

CENX

Century Aluminum

$16.27

-0.07 (-0.43%)

AOBC

American Outdoor Brands

$12.53

0.05 (0.40%)

RGR

Sturm, Ruger

$63.10

0.5 (0.80%)

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HCLP

Hi-Crush Partners

$13.20

-0.825 (-5.88%)

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POST

Post Holdings

$77.98

1.49 (1.95%)

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ABMD

Abiomed

$394.49

0.04 (0.01%)

, WYN

Wyndham

$107.98

-0.58 (-0.53%)

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Abiomed to enter S&P 500 index on May 31 »

S&P MidCap 400…

ABMD

Abiomed

$394.49

0.04 (0.01%)

WYN

Wyndham

$107.98

-0.58 (-0.53%)

MSCC

Microsemi

$68.74

0.005 (0.01%)

PRAH

PRA Health

$81.19

0.33 (0.41%)

GME

GameStop

$12.64

-0.1 (-0.78%)

FRED

Fred's

$1.69

0.05 (3.05%)

PRSP

Symbol now PB

$0.00

(0.00%)

RRTS

Roadrunner

$2.19

0.04 (1.86%)

DXC

DXC Technology

$94.20

-5.42 (-5.44%)

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PRAH

PRA Health

$81.19

0.33 (0.41%)

, ABMD

Abiomed

$394.49

0.04 (0.01%)

17:24
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05/25
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17:24
Hot Stocks
Breaking Hot Stocks news story on PRA Health, Abiomed »

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PRAH

PRA Health

$81.19

0.33 (0.41%)

ABMD

Abiomed

$394.49

0.04 (0.01%)

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WYN

Wyndham

$107.98

-0.58 (-0.53%)

, MSCC

Microsemi

$68.74

0.005 (0.01%)

17:23
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Breaking Hot Stocks news story on Wyndham, Microsemi »

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WYN

Wyndham

$107.98

-0.58 (-0.53%)

MSCC

Microsemi

$68.74

0.005 (0.01%)

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ABMD

Abiomed

$394.49

0.04 (0.01%)

, WYN

Wyndham

$107.98

-0.58 (-0.53%)

17:21
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Hot Stocks
Breaking Hot Stocks news story on Abiomed, Wyndham »

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ABMD

Abiomed

$394.49

0.04 (0.01%)

WYN

Wyndham

$107.98

-0.58 (-0.53%)

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PCG

PG&E

$44.67

0.84 (1.92%)

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FARM

Farmer Bros.

$28.50

0.15 (0.53%)

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NDLS

Noodles & Company

$8.90

-0.35 (-3.78%)

17:07
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Breaking Syndicate news story on Noodles & Company »

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WIN

Windstream

$1.22

-0.125 (-9.29%)

17:06
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NDLS

Noodles & Company

$8.90

-0.35 (-3.78%)

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Syndicate
Breaking Syndicate news story on Noodles & Company »

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EPD

Enterprise Products

$27.87

-0.12 (-0.43%)

17:01
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INO

Inovio

$4.89

0.06 (1.24%)

16:37
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Breaking Syndicate news story on Inovio »

Inovio files $250M mixed…

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RCII

Rent-A-Center

$10.14

0.13 (1.30%)

16:36
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AKER

Akers Biosciences

$0.59

0.0086 (1.48%)

16:34
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05/25
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Akers Biosciences receives delinquency notice from NASDAQ »

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DHCP

Ditech

$6.60

0.37 (5.94%)

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GPS

Gap

$28.15

-4.82 (-14.62%)

, FL

Foot Locker

$55.97

9.585 (20.67%)

16:30
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General news
On The Fly: Top stock stories for Friday »

Stocks on Wall Street…

GPS

Gap

$28.15

-4.82 (-14.62%)

FL

Foot Locker

$55.97

9.585 (20.67%)

HLF

Herbalife Nutrition

$48.76

-5.09 (-9.45%)

IEP

Icahn Enterprises

$69.41

0.22 (0.32%)

FCAU

Fiat Chrysler

$21.82

-0.445 (-2.00%)

DGX

Quest Diagnostics

$105.89

5 (4.96%)

UNH

UnitedHealth

$244.96

2.23 (0.92%)

ROST

Ross Stores

$77.35

-5.6 (-6.75%)

ADSK

Autodesk

$132.80

-5.96 (-4.30%)

AAL

American Airlines

$44.89

1.34 (3.08%)

LUV

Southwest

$52.86

1.65 (3.22%)

DAL

Delta Air Lines

$55.89

1.48 (2.72%)

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16:30
05/25/18
05/25
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16:30
Options
Preliminary option volume of 16.4M today »

Preliminary option volume…

VTL

Vital Therapies

$5.65

-0.475 (-7.76%)

16:26
05/25/18
05/25
16:26
05/25/18
16:26
Syndicate
Breaking Syndicate news story on Vital Therapies »

Vital Therapies files to…

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