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ALNY

Alnylam

$128.20

-2.69 (-2.06%)

, SNY

Sanofi

$43.70

0.46 (1.06%)

07:01
12/12/17
12/12
07:01
12/12/17
07:01

Alnylam completes submission of NDA for Patisiran for hATTR amyloidosis

Alnylam Pharmaceuticals (ALNY) announced the completion of the rolling submission of a New Drug Application to the U.S. FDA for patisiran, an investigational RNAi therapeutic targeting transthyretin for the treatment of adults with hereditary transthyretin-mediated amyloidosis. The rolling submission began on November 15, 2017 with the nonclinical and chemistry, manufacturing and controls components submitted, and now submission of the clinical data completes the filing. Alnylam has requested priority review for the application which, if granted, could result in a six-month review process. Patisiran previously received Fast Track and Breakthrough Therapy designations from the FDA, and recently received an expanded Orphan Drug Designation for ATTR amyloidosis. Patisiran also has been granted accelerated assessment by the European Medicines Agency. Alnylam, in collaboration with Sanofi Genzyme (SNY), intends to file a Marketing Authorization Application in the European Union around year-end. Sanofi Genzyme is currently preparing for regulatory filings for patisiran in Japan, Brazil and other countries, to begin in the first half of 2018. Pending regulatory approvals, Alnylam will commercialize patisiran in the U.S., Canada and Western Europe, with Sanofi Genzyme commercializing the product in the rest of the world, including certain Central and Eastern European countries of the European Union.

ALNY

Alnylam

$128.20

-2.69 (-2.06%)

SNY

Sanofi

$43.70

0.46 (1.06%)

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ALNY Alnylam
$128.20

-2.69 (-2.06%)

11/17/17
PIPR
11/17/17
NO CHANGE
Target $182
PIPR
Overweight
Piper trims Alnylam target to $182 after capital raise
Piper Jaffray analyst Edward Tenthoff trimmed his price target for Alnylam Pharmaceuticals to $182 from $188 to account for dilution from the company's issuance of 6.44M shares at $125. The company's cash position of $1.93B will allow for the patisiran launch and pipeline advancements, Tenthoff tells investors in a research note. He reiterates an Overweight rating on Alnylam.
11/09/17
JPMS
11/09/17
UPGRADE
Target $162
JPMS
Overweight
Alnylam upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst Anupam Rama upgraded Alnylam Pharmaceuticals saying he believes patisiran "has definitively solidified" a dominant market position in the ATTR amyloidosis space. The analyst expects a "smooth regulatory process" for patisiran and broad label enabling use in the mutant mixed FAC phenotype. Rama raised his price target for Alnylam shares to $162 from $86.
11/08/17
LEHM
11/08/17
NO CHANGE
Target $158
LEHM
Overweight
Alnylam price target raised to $158 from $127 at Barclays
Barclays analyst Gena Wang raised her price target for Alnylam Pharmaceuticals to $158 saying the company highlighted multiple pipeline progresses during the Q3 earnings call. The analyst keeps an Overweight rating on the shares.
11/03/17
COWN
11/03/17
NO CHANGE
Target $151
COWN
Outperform
Alnylam price target raised to $151 from $117 at Cowen
Cowen analyst Ritu Baral raised her price target on Alnylam to $151 from $117 following its presentation of full data from the Phase 3 APOLLO trial of patisiran. The data showed benefits in cardiac measure and excellent safety and approval should be expected in 2018 with a broad label. Baral reiterated her Outperform rating on Alnylam shares.
SNY Sanofi
$43.70

0.46 (1.06%)

12/06/17
BOFA
12/06/17
DOWNGRADE
BOFA
Neutral
Sanofi downgraded to Neutral from Buy at BofA/Merrill
BofA/Merrill analyst Graham Perry downgraded Sanofi to Neutral citing valuation and lack of earnings momentum into 2018.
12/01/17
MSCO
12/01/17
DOWNGRADE
MSCO
Underweight
Sanofi downgraded to Underweight from Overweight at Morgan Stanley
11/16/17
EVER
11/16/17
NO CHANGE
Target $445
EVER
Outperform
Regeneron price target lowered to $445 from $605 at Evercore ISI
Evercore ISI lowered its price target for Regeneron (REGN) to $445 from $605 given meaningful competitive threat to Eylea. For every dollar of U.S. Eylea sales lost to competition, Regeneron has to make up for it with two times as much revenue from the Sanofi (SNY) JV, it adds. The firm has an Outperform rating on Regeneron's shares.
11/15/17
LEHM
11/15/17
UPGRADE
LEHM
Equal Weight
Sanofi upgraded to Equal Weight from Underweight at Barclays
Barclays upgraded Sanofi to Equal Weight from Underweight saying valuation is back to more reasonable levels.

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PHAS

PhaseBio

$0.00

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Syndicate
PhaseBio 9.2M share IPO priced at $5.00 »

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MSC

Studio City

$0.00

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Studio City 28.75M share IPO priced at $12.50 »

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BHGE

Baker Hughes

$30.75

-0.09 (-0.29%)

, CJ

C&J Energy Services

$20.40

-0.12 (-0.58%)

20:38
10/17/18
10/17
20:38
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20:38
Recommendations
Baker Hughes, C&J Energy Services, FTS International, Halliburton, Keane Group, Nabors Industries, Nine Energy Services, Patterson-UTI, ProPetro Holding, Schlumberger, Covia , Helmerich & Payne, U.S. Silica, Weatherford analyst commentary at BofA/Merrill »

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BHGE

Baker Hughes

$30.75

-0.09 (-0.29%)

CJ

C&J Energy Services

$20.40

-0.12 (-0.58%)

FTSI

FTS International

$12.87

-0.115 (-0.89%)

HAL

Halliburton

$39.56

-0.52 (-1.30%)

FRAC

Keane Group

$12.50

-0.14 (-1.11%)

NBR

Nabors Industries

$6.25

-0.175 (-2.72%)

NINE

Nine Energy Services

$39.10

0.31 (0.80%)

PTEN

Patterson-UTI

$16.58

-0.37 (-2.18%)

PUMP

ProPetro Holding

$18.19

-0.315 (-1.70%)

SLB

Schlumberger

$59.24

-0.43 (-0.72%)

CVIA

Covia

$7.01

-0.57 (-7.52%)

HP

Helmerich & Payne

$68.06

-1.13 (-1.63%)

SLCA

U.S. Silica

$17.69

-1.03 (-5.50%)

WFT

Weatherford

$2.61

-0.03 (-1.14%)

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PM

Philip Morris

$84.62

1.12 (1.34%)

, DHR

Danaher

$104.95

-0.13 (-0.12%)

20:25
10/17/18
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20:25
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20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

PM

Philip Morris

$84.62

1.12 (1.34%)

DHR

Danaher

$104.95

-0.13 (-0.12%)

BK

BNY Mellon

$49.16

-0.17 (-0.34%)

NVS

Novartis

$85.34

-0.41 (-0.48%)

BX

Blackstone

$36.06

-0.02 (-0.06%)

BBT

BB&T

$47.73

0.64 (1.36%)

TRV

Travelers

$126.47

1.75 (1.40%)

PPG

PPG

$98.15

-0.06 (-0.06%)

KEY

KeyCorp

$18.75

0.17 (0.91%)

NUE

Nucor

$59.11

0.17 (0.29%)

TXT

Textron

$64.72

-2.01 (-3.01%)

GPC

Genuine Parts

$95.26

-1.83 (-1.88%)

DOV

Dover

$82.28

-0.95 (-1.14%)

WBC

Wabco

$103.09

-6.91 (-6.28%)

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AVMXY

Avita Medical

$0.00

(0.00%)

19:55
10/17/18
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19:55
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19:55
Hot Stocks
Avita Medical announces first U.S. sales of Recell system »

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FRAC

Keane Group

$12.50

-0.14 (-1.11%)

19:33
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19:33
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19:33
Initiation
Keane Group initiated at BofA/Merrill »

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NBR

Nabors Industries

$6.25

-0.175 (-2.72%)

19:28
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19:28
Initiation
Nabors Industries initiated at BofA/Merrill »

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NINE

Nine Energy Services

$39.10

0.31 (0.80%)

19:19
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19:19
Initiation
Nine Energy Services initiated at BofA/Merrill »

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PTEN

Patterson-UTI

$16.58

-0.37 (-2.18%)

19:17
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19:17
Initiation
Patterson-UTI initiated at BofA/Merrill »

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GSBC

Great Southern Bancorp

$52.51

0.26 (0.50%)

19:04
10/17/18
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19:04
Earnings
Great Southern Bancorp reports preliminary Q3 EPS $1.18, consensus $1.06 »

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HMNY

Helios and Matheson

$0.02

0.001 (5.18%)

18:59
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18:59
Periodicals
Breaking Periodicals news story on Helios and Matheson »

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BY

Byline Bancorp

$21.33

0.02 (0.09%)

18:51
10/17/18
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Hot Stocks
Byline Bancorp to acquire Oak Park River Forest Bankshares for $42M »

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ABB

ABB

$21.37

-0.115 (-0.54%)

18:48
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18:48
Periodicals
ABB weighs divesting $10B power grid business, Bloomberg reports »

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VEC

Vectrus

$28.98

-0.74 (-2.49%)

18:22
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18:22
Hot Stocks
Vectrus names Kevin Boyle chief legal officer »

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S

Sprint

$6.41

-0.005 (-0.08%)

18:21
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Sprint extends credits to Florida customers impacted by Hurricane Michael »

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TALO

Talos Energy

$29.85

-1.49 (-4.75%)

18:05
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Hot Stocks
Talos Energy reaches pact with Hokchi to cross-assign interests »

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STLD

Steel Dynamics

$40.55

0.29 (0.72%)

18:05
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18:05
Hot Stocks
Steel Dynamics CEO says 'delivered a tremendous third quarter performance' »

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STLD

Steel Dynamics

$40.55

0.29 (0.72%)

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Steel Dynamics CEO: We believe steel consumption will continue to be strong »

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STLD

Steel Dynamics

$40.55

0.29 (0.72%)

18:01
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18:01
Earnings
Steel Dynamics reports Q3 adjusted EPS $1.69, consensus $1.64 »

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CRTO

Criteo

$23.00

-0.29 (-1.25%)

, RUBI

Rubicon Project

$3.77

-0.06 (-1.57%)

17:44
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17:44
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Periodicals
Advertising technology firm DataXu exploring sale, WSJ says »

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CRTO

Criteo

$23.00

-0.29 (-1.25%)

RUBI

Rubicon Project

$3.77

-0.06 (-1.57%)

FUEL

Rocket Fuel

$0.00

(0.00%)

GOOG

Alphabet

$1,115.99

-4.12 (-0.37%)

FB

Facebook

$159.46

0.65 (0.41%)

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BTU

Peabody Energy

$36.09

-0.31 (-0.85%)

17:37
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Hot Stocks
Peabody Energy increases quarterly dividend nearly 4% to 13c per share »

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BDN

Brandywine Realty

$14.56

-0.11 (-0.75%)

17:34
10/17/18
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Earnings
Brandywine Realty sees FY19 FFO $1.37-$1.47, consensus $1.44 »

Sees FY17 EPS 36c-46c,…

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