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ONCE

Spark Therapeutics

$47.72

-25.66 (-34.97%)

10:54
12/12/17
12/12
10:54
12/12/17
10:54

Spark Therapeutics upgraded to Neutral from Underperform at Wedbush

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ONCE Spark Therapeutics
$47.72

-25.66 (-34.97%)

12/12/17
LEER
12/12/17
DOWNGRADE
Target $49
LEER
Market Perform
Spark Therapeutics downgraded to Market Perform from Outperform at Leerink
Leerink analyst Joseph Schwartz downgraded Spark Therapeutics (ONCE) to Market Perform and cut his price target for the shares to $49 from $97. UBS this morning also downgraded the shares. The loss of expression and erratic responses to date indicate it will be more difficult for Spark's SPK-8011 to differentiate itself favorably relative to BioMarin's (BMRN) Valrox, Schwartz tells investors in a research note. The analyst sees a low likelihood that the next SPK-8011 data provides a clear picture of efficacy.
12/12/17
BMOC
12/12/17
NO CHANGE
Target $73
BMOC
Outperform
Spark Therapeutics price target lowered to $73 from $101 at BMO Capital
BMO Capital analyst Matthew Luchini cut his price target on Spark Therapeutics to $73 after its update on SPK-8011 failed to show a dose response and potential need for concomitant steroids. Luchini also lowered his probability of success for the treatment to 15% from 45% while extending its timeline for potential launch to 2022. The analyst keeps his Outperform rating on Spark Therapeutics, saying the current weakness is overdone thanks to support from its hemophilia B gene therapy and Luxturna programs.
12/12/17
BERN
12/12/17
NO CHANGE
BERN
Spark Therapeutics should be bought on weakness, says Bernstein
Bernstein analyst Vincent Chen notes that while BioMarin (BMRN) hemophilia gene therapy data was as expected, Spark Therapeutics' (ONCE) data was quite confounding. Nonetheless, he thinks the stock reaction is overdone. Spark's results are not positive, but he would not write off SPK-8011 or the platform. Chen says he would buy on weakness.
12/12/17
12/12/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Juno Therapeutics (JUNO) downgraded to Market Perform from Outperform at Wells Fargo, with analyst Jim Birchenough saying that while data for JCAR017 continue to support a potential best-in-class profile in aggressive lymphoma, the current valuation already reflects dominant market positioning over Gilead's (GILD) Yescarta. 2. General Dynamics (GD) downgraded to Underweight from Neutral at JPMorgan, with analyst Seth Seifman saying Gulfstream questions are unlikely to be resolved in the near term. Demand for G500/600 is ok for now, but uncertainty about ultimate production levels and the pace of the learning curve mean the transition will remain a near term overhang, the analyst said. Seifman also downgraded Raytheon (RTN) to Neutral from Underweight. 3. Adobe (ADBE), Barracuda (CUDA), GoDaddy (GDDY), Fortinet (FTNT) and Check Point (CHKP) downgraded to Neutral from Overweight and CoStar Group (CSGP), Imperva (IMPV) and Monotype Imaging (TYPE) downgraded to Underweight from Overweight at JPMorgan by analyst Sterling Auty in conjunction with his 2018 annual outlook for Software Technology. The analyst does not expect the "exceptional performance" in Software during 2017 to repeat in 2018. 4. Spark Therapeutics (ONCE) downgraded to Neutral from Buy at UBS, with analyst Carter Gould seeing a "challenging setup" for the shares after the Phase 1/2 SPK-8011 data in hemophilia A fell short of expectations. The analyst removed SPK-8011, or $29 per share, and early-stage pipeline value, or $12 per share, from his model. He finds it difficult to be more constructive on Spark shares in the near-term. 5. Electronic Arts (EA) downgraded to Buy from Conviction Buy at Goldman Sachs by analyst Christopher Merwin to reflect fewer near-term catalysts around in-game monetization of non-sports titles. To see The Fly's full Street Research coverage, click here.

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