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ALNY

Alnylam

$123.66

-1.2 (-0.96%)

, SNY

Sanofi

$43.09

-0.83 (-1.89%)

07:04
12/15/17
12/15
07:04
12/15/17
07:04

Alnylam announces lift of FDA clinical hold on Fitusiran

Alnylam Pharmaceuticals (ALNY) and Sanofi Genzyme, the specialty care global business unit of Sanofi (SNY), announced today that the U.S. Food and Drug Administration has lifted the hold on clinical studies with fitusiran, including the Phase 2 open-label extension study and the ATLAS Phase 3 program. Alnylam and the FDA had previously reached alignment on new clinical risk mitigation measures, including protocol-specified guidelines and additional investigator and patient education concerning reduced doses of replacement factor or bypassing agent to treat any breakthrough bleeds in fitusiran studies. The FDA has now approved the protocol amendments and other updated clinical materials for fitusiran studies. Fitusiran is an investigational RNAi therapeutic targeting antithrombin for the treatment of patients with hemophilia A and B. It is designed to lower levels of AT with the goal of promoting sufficient thrombin generation to restore hemostasis and prevent bleeding.

ALNY

Alnylam

$123.66

-1.2 (-0.96%)

SNY

Sanofi

$43.09

-0.83 (-1.89%)

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ALNY Alnylam
$123.66

-1.2 (-0.96%)

11/17/17
PIPR
11/17/17
NO CHANGE
Target $182
PIPR
Overweight
Piper trims Alnylam target to $182 after capital raise
Piper Jaffray analyst Edward Tenthoff trimmed his price target for Alnylam Pharmaceuticals to $182 from $188 to account for dilution from the company's issuance of 6.44M shares at $125. The company's cash position of $1.93B will allow for the patisiran launch and pipeline advancements, Tenthoff tells investors in a research note. He reiterates an Overweight rating on Alnylam.
11/09/17
JPMS
11/09/17
UPGRADE
Target $162
JPMS
Overweight
Alnylam upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst Anupam Rama upgraded Alnylam Pharmaceuticals saying he believes patisiran "has definitively solidified" a dominant market position in the ATTR amyloidosis space. The analyst expects a "smooth regulatory process" for patisiran and broad label enabling use in the mutant mixed FAC phenotype. Rama raised his price target for Alnylam shares to $162 from $86.
11/08/17
LEHM
11/08/17
NO CHANGE
Target $158
LEHM
Overweight
Alnylam price target raised to $158 from $127 at Barclays
Barclays analyst Gena Wang raised her price target for Alnylam Pharmaceuticals to $158 saying the company highlighted multiple pipeline progresses during the Q3 earnings call. The analyst keeps an Overweight rating on the shares.
11/03/17
COWN
11/03/17
NO CHANGE
Target $151
COWN
Outperform
Alnylam price target raised to $151 from $117 at Cowen
Cowen analyst Ritu Baral raised her price target on Alnylam to $151 from $117 following its presentation of full data from the Phase 3 APOLLO trial of patisiran. The data showed benefits in cardiac measure and excellent safety and approval should be expected in 2018 with a broad label. Baral reiterated her Outperform rating on Alnylam shares.
SNY Sanofi
$43.09

-0.83 (-1.89%)

12/06/17
BOFA
12/06/17
DOWNGRADE
BOFA
Neutral
Sanofi downgraded to Neutral from Buy at BofA/Merrill
BofA/Merrill analyst Graham Perry downgraded Sanofi to Neutral citing valuation and lack of earnings momentum into 2018.
12/01/17
MSCO
12/01/17
DOWNGRADE
MSCO
Underweight
Sanofi downgraded to Underweight from Overweight at Morgan Stanley
11/16/17
EVER
11/16/17
NO CHANGE
Target $445
EVER
Outperform
Regeneron price target lowered to $445 from $605 at Evercore ISI
Evercore ISI lowered its price target for Regeneron (REGN) to $445 from $605 given meaningful competitive threat to Eylea. For every dollar of U.S. Eylea sales lost to competition, Regeneron has to make up for it with two times as much revenue from the Sanofi (SNY) JV, it adds. The firm has an Outperform rating on Regeneron's shares.
11/15/17
LEHM
11/15/17
UPGRADE
LEHM
Equal Weight
Sanofi upgraded to Equal Weight from Underweight at Barclays
Barclays upgraded Sanofi to Equal Weight from Underweight saying valuation is back to more reasonable levels.

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CAT

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SYMC

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SYMC

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CMCSA

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CVX

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WMT

Walmart

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1.19 (1.16%)

, HTZ

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WMT

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HTZ

Hertz

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FLR

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EXAS

Exact Sciences

$47.68

-5.27 (-9.95%)

10:38
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Conference/Events
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UCTT

Ultra Clean

$24.98

1.32 (5.58%)

10:36
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BHP

BHP Billiton

$49.15

-0.29 (-0.59%)

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MNK

Mallinckrodt

$21.19

-1.095 (-4.91%)

10:35
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TOL

Toll Brothers

$52.28

0.21 (0.40%)

10:34
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EXEL

Exelixis

$27.49

-2.16 (-7.29%)

, IPSEY

Ipsen

$34.14

2.95 (9.46%)

10:31
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EXEL

Exelixis

$27.49

-2.16 (-7.29%)

IPSEY

Ipsen

$34.14

2.95 (9.46%)

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10:30
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EIA natural gas storage change for week ending January 12 »

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TIVO

TiVo

$14.50

0.1 (0.69%)

, GOOGL

Alphabet Class A

$1,139.10

8.4 (0.74%)

10:26
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Hot Stocks
TiVo rises amid expanded patent license agreement with Google »

Shares of TiVo (TIVO) are…

TIVO

TiVo

$14.50

0.1 (0.69%)

GOOGL

Alphabet Class A

$1,139.10

8.4 (0.74%)

GOOG

Alphabet

$1,131.98

10.22 (0.91%)

T

AT&T

$37.33

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SNE

Sony

$49.09

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SNAP

Snap

$13.84

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, FB

Facebook

$177.60

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Conference/Events
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Snap

$13.84

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FB

Facebook

$177.60

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GOOG

Alphabet

$1,131.98

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GOOGL

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$1,139.10

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TWTR

Twitter

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DIS

Disney

$111.57

-0.4 (-0.36%)

, VIA

Viacom

$37.85

0.95 (2.57%)

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DIS

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VIA

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TWX

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CMCSA

Comcast

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SPB

Spectrum Brands

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DISH

Dish

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NFLX

Netflix

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AMZN

Amazon.com

$1,295.00

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MDXG

MiMedx

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JNPR

Juniper

$28.15

-0.52 (-1.81%)

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Call buyer on weakness in Juniper Networks »

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ERIC

Ericsson

$7.34

0.4 (5.76%)

, BCE

BCE

$46.36

-0.1301 (-0.28%)

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BCE

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$46.36

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$NSD

NASDAQ Market Internals

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NASDAQ market internals summary »

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$NYE

NYSE Market Internals

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NYSE market internals summary »

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AMZN

Amazon.com

$1,295.00

-9.86 (-0.76%)

10:16
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10:15
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General news
Breaking General news story  »

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TLT

iShares 20+ Year Treasury Bond Fund

$124.87

-0.17 (-0.14%)

10:10
01/18/18
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10:10
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Defensive option play in iShares Longer-term Bond Fund »

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10:10
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Treasury Option Action: heavy call positioning »

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LGF.A

Lionsgate

$33.69

1.41 (4.37%)

, CBS

CBS

$59.73

0.83 (1.41%)

10:05
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Lionsgate jumps after report on potential takeover interest »

Shares of Lionsgate…

LGF.A

Lionsgate

$33.69

1.41 (4.37%)

CBS

CBS

$59.73

0.83 (1.41%)

CBS.A

$59.79

0.75 (1.27%)

VIA

Viacom

$37.85

0.95 (2.57%)

VIAB

Viacom

$31.96

0.58 (1.85%)

AMZN

Amazon.com

$1,295.00

-9.86 (-0.76%)

VZ

Verizon

$52.68

0.955 (1.85%)

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