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ALNY

Alnylam

$123.66

-1.2 (-0.96%)

, SNY

Sanofi

$43.09

-0.83 (-1.89%)

07:04
12/15/17
12/15
07:04
12/15/17
07:04

Alnylam announces lift of FDA clinical hold on Fitusiran

Alnylam Pharmaceuticals (ALNY) and Sanofi Genzyme, the specialty care global business unit of Sanofi (SNY), announced today that the U.S. Food and Drug Administration has lifted the hold on clinical studies with fitusiran, including the Phase 2 open-label extension study and the ATLAS Phase 3 program. Alnylam and the FDA had previously reached alignment on new clinical risk mitigation measures, including protocol-specified guidelines and additional investigator and patient education concerning reduced doses of replacement factor or bypassing agent to treat any breakthrough bleeds in fitusiran studies. The FDA has now approved the protocol amendments and other updated clinical materials for fitusiran studies. Fitusiran is an investigational RNAi therapeutic targeting antithrombin for the treatment of patients with hemophilia A and B. It is designed to lower levels of AT with the goal of promoting sufficient thrombin generation to restore hemostasis and prevent bleeding.

ALNY

Alnylam

$123.66

-1.2 (-0.96%)

SNY

Sanofi

$43.09

-0.83 (-1.89%)

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ALNY Alnylam
$123.66

-1.2 (-0.96%)

11/17/17
PIPR
11/17/17
NO CHANGE
Target $182
PIPR
Overweight
Piper trims Alnylam target to $182 after capital raise
Piper Jaffray analyst Edward Tenthoff trimmed his price target for Alnylam Pharmaceuticals to $182 from $188 to account for dilution from the company's issuance of 6.44M shares at $125. The company's cash position of $1.93B will allow for the patisiran launch and pipeline advancements, Tenthoff tells investors in a research note. He reiterates an Overweight rating on Alnylam.
11/09/17
JPMS
11/09/17
UPGRADE
Target $162
JPMS
Overweight
Alnylam upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst Anupam Rama upgraded Alnylam Pharmaceuticals saying he believes patisiran "has definitively solidified" a dominant market position in the ATTR amyloidosis space. The analyst expects a "smooth regulatory process" for patisiran and broad label enabling use in the mutant mixed FAC phenotype. Rama raised his price target for Alnylam shares to $162 from $86.
11/08/17
LEHM
11/08/17
NO CHANGE
Target $158
LEHM
Overweight
Alnylam price target raised to $158 from $127 at Barclays
Barclays analyst Gena Wang raised her price target for Alnylam Pharmaceuticals to $158 saying the company highlighted multiple pipeline progresses during the Q3 earnings call. The analyst keeps an Overweight rating on the shares.
11/03/17
COWN
11/03/17
NO CHANGE
Target $151
COWN
Outperform
Alnylam price target raised to $151 from $117 at Cowen
Cowen analyst Ritu Baral raised her price target on Alnylam to $151 from $117 following its presentation of full data from the Phase 3 APOLLO trial of patisiran. The data showed benefits in cardiac measure and excellent safety and approval should be expected in 2018 with a broad label. Baral reiterated her Outperform rating on Alnylam shares.
SNY Sanofi
$43.09

-0.83 (-1.89%)

12/06/17
BOFA
12/06/17
DOWNGRADE
BOFA
Neutral
Sanofi downgraded to Neutral from Buy at BofA/Merrill
BofA/Merrill analyst Graham Perry downgraded Sanofi to Neutral citing valuation and lack of earnings momentum into 2018.
12/01/17
MSCO
12/01/17
DOWNGRADE
MSCO
Underweight
Sanofi downgraded to Underweight from Overweight at Morgan Stanley
11/16/17
EVER
11/16/17
NO CHANGE
Target $445
EVER
Outperform
Regeneron price target lowered to $445 from $605 at Evercore ISI
Evercore ISI lowered its price target for Regeneron (REGN) to $445 from $605 given meaningful competitive threat to Eylea. For every dollar of U.S. Eylea sales lost to competition, Regeneron has to make up for it with two times as much revenue from the Sanofi (SNY) JV, it adds. The firm has an Outperform rating on Regeneron's shares.
11/15/17
LEHM
11/15/17
UPGRADE
LEHM
Equal Weight
Sanofi upgraded to Equal Weight from Underweight at Barclays
Barclays upgraded Sanofi to Equal Weight from Underweight saying valuation is back to more reasonable levels.

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JPM

JPMorgan

$113.44

0.45 (0.40%)

12:41
01/18/18
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12:41
Periodicals
JPMorgan sued for over $875M by Nigeria over 2011 oilfield deal, Reuters reports »

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FSNN

Fusion Telecommunications

$3.83

-0.03 (-0.78%)

12:33
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Hot Stocks
Cooper Creek Partners reports 5.17% passive stake in Fusion Telecommunications »

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AMZN

Amazon.com

$1,295.00

-9.86 (-0.76%)

, MS

Morgan Stanley

$55.59

0.235 (0.42%)

12:29
01/18/18
01/18
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01/18/18
12:29
General news
On The Fly: Top stock stories at midday »

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AMZN

Amazon.com

$1,295.00

-9.86 (-0.76%)

MS

Morgan Stanley

$55.59

0.235 (0.42%)

LGF.A

Lionsgate

$34.99

2.71 (8.40%)

CBS

CBS

$61.09

2.19 (3.72%)

VIAB

Viacom

$31.96

0.58 (1.85%)

VIA

Viacom

$37.85

0.95 (2.57%)

GNC

GNC Holdings

$4.95

1.48 (42.65%)

PTC

PTC

$66.70

1.41 (2.16%)

AA

Alcoa

$52.37

-4.6199 (-8.11%)

ENDP

Endo

$7.69

-0.32 (-4.00%)

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IP

International Paper

$62.23

0.74 (1.20%)

12:25
01/18/18
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Options
International Paper call volume above normal and directionally bullish »

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FMC

FMC Corporation

$88.41

-5.45 (-5.81%)

12:23
01/18/18
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12:23
Recommendations
FMC Corporation analyst commentary  »

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BBBY

Bed Bath & Beyond

$23.40

0.39 (1.69%)

12:21
01/18/18
01/18
12:21
01/18/18
12:21
Hot Stocks
Bed Bath & Beyond recalls Hudson Comforters on mold exposure 

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COLB

Columbia Banking

$45.94

0.36 (0.79%)

12:19
01/18/18
01/18
12:19
01/18/18
12:19
Hot Stocks
Columbia Bank names Lisa Dow chief risk officer »

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ACOR

Acorda Therapeutics

$24.75

-0.3 (-1.20%)

12:17
01/18/18
01/18
12:17
01/18/18
12:17
Periodicals
Acorda Therapeutics jumps after web report about takeover approach »

According to a report…

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$NSD

NASDAQ Market Internals

12:17
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Technical Analysis
NASDAQ market internals summary »

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$NYE

NYSE Market Internals

12:16
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Technical Analysis
NYSE market internals summary »

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12:15
01/18/18
01/18
12:15
01/18/18
12:15
General news
Atlanta Fed's Q4 GDPNow estimate was raised to 3.4%: »

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AMZN

Amazon.com

$1,295.00

-9.86 (-0.76%)

, SNE

Sony

$49.18

-0.6438 (-1.29%)

12:12
01/18/18
01/18
12:12
01/18/18
12:12
Periodicals
Amazon looks to compete in commercial films, less indies, Reuters says »

Amazon (AMZN) is looking…

AMZN

Amazon.com

$1,295.00

-9.86 (-0.76%)

SNE

Sony

$49.18

-0.6438 (-1.29%)

FOX

21st Century Fox

$36.49

0.7 (1.96%)

TWX

Time Warner

$92.31

0.14 (0.15%)

VIA

Viacom

$37.85

0.95 (2.57%)

CMCSA

Comcast

$41.68

-0.14 (-0.33%)

DIS

Disney

$111.33

-0.64 (-0.57%)

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MELI

MercadoLibre

$340.45

0.6 (0.18%)

12:10
01/18/18
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01/18/18
12:10
Options
$45.5M option print in MercadoLibre »

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FMC

FMC Corporation

$87.26

-6.6001 (-7.03%)

, SQM

SQM

$57.76

-1.79 (-3.01%)

12:06
01/18/18
01/18
12:06
01/18/18
12:06
Recommendations
FMC Corporation, SQM analyst commentary  »

FMC Corporation selloff…

FMC

FMC Corporation

$87.26

-6.6001 (-7.03%)

SQM

SQM

$57.76

-1.79 (-3.01%)

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AXP

American Express

$100.20

-0.56 (-0.56%)

, V

Visa

$122.37

0.39 (0.32%)

12:06
01/18/18
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12:06
Earnings
On The Fly: What to watch in credit card space earnings reports »

American Express (AXP) is…

AXP

American Express

$100.20

-0.56 (-0.56%)

V

Visa

$122.37

0.39 (0.32%)

MA

MasterCard

$164.92

0.6 (0.37%)

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DIS

Disney

$111.22

-0.75 (-0.67%)

12:03
01/18/18
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12:03
Hot Stocks
Disney, Twitch announce multi-year content partnership »

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INTC

Intel

$44.39

1.25 (2.90%)

12:01
01/18/18
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Hot Stocks
Intel debuts technologies, including RealSense Volumetric Content Capture »

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FMC

FMC Corporation

$87.26

-6.6 (-7.03%)

, SQM

SQM

$57.49

-2.065 (-3.47%)

12:00
01/18/18
01/18
12:00
01/18/18
12:00
Recommendations
FMC Corporation, SQM analyst commentary  »

FMC Corporation pullback…

FMC

FMC Corporation

$87.26

-6.6 (-7.03%)

SQM

SQM

$57.49

-2.065 (-3.47%)

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SBAC

SBA Communications

$161.47

1.62 (1.01%)

12:00
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Options
One-day put sellers in SBA Comm »

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LGF.A

Lionsgate

$33.90

1.62 (5.02%)

, CBS

CBS

$61.09

2.19 (3.72%)

11:58
01/18/18
01/18
11:58
01/18/18
11:58
Hot Stocks
Lionsgate jumps after report on potential takeover interest »

Shares of Lionsgate…

LGF.A

Lionsgate

$33.90

1.62 (5.02%)

CBS

CBS

$61.09

2.19 (3.72%)

VIAB

Viacom

$31.96

0.58 (1.85%)

VIA

Viacom

$37.85

0.95 (2.57%)

AMZN

Amazon.com

$1,295.00

-9.86 (-0.76%)

VZ

Verizon

$52.78

1.055 (2.04%)

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ADP

ADP

$122.05

2.66 (2.23%)

, CSOD

Cornerstone OnDemand

$39.28

0.34 (0.87%)

11:52
01/18/18
01/18
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01/18/18
11:52
Conference/Events
Stephens enterprise software analyst holds analyst/industry conference call »

Enterprise Software…

ADP

ADP

$122.05

2.66 (2.23%)

CSOD

Cornerstone OnDemand

$39.28

0.34 (0.87%)

MSFT

Microsoft

$90.14

1.79 (2.03%)

ORCL

Oracle

$50.26

-0.01 (-0.02%)

PAYC

Paycom

$88.34

-0.01 (-0.01%)

PCTY

Paylocity

$49.46

0.71 (1.46%)

SAP

SAP

$111.45

0.2601 (0.23%)

ULTI

Ultimate Software

$226.26

3.48 (1.56%)

WDAY

Workday

$112.26

2.17 (1.97%)

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DXCM

Dexcom

$56.32

-0.09 (-0.16%)

, ABT

Abbott

$58.77

-0.22 (-0.37%)

11:51
01/18/18
01/18
11:51
01/18/18
11:51
Hot Stocks
Dexcom dips with Cigna deeming Abbott's Libre medically necessary »

Shares of Dexcom (DXCM)…Reference Link

DXCM

Dexcom

$56.32

-0.09 (-0.16%)

ABT

Abbott

$58.77

-0.22 (-0.37%)

CI

Cigna

$218.45

-1.915 (-0.87%)

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MBI

MBIA

$7.38

-0.01 (-0.14%)

11:50
01/18/18
01/18
11:50
01/18/18
11:50
Options
Large option blocks in MBIA as a defensive play is adjusted »

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GNC

GNC Holdings

$4.72

1.25 (36.02%)

11:48
01/18/18
01/18
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11:48
Recommendations
GNC Holdings analyst commentary  »

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IBM

IBM

$169.22

0.57 (0.34%)

11:41
01/18/18
01/18
11:41
01/18/18
11:41
Technical Analysis
Technical Earnings Preview: IBM in a bullish pattern ahead of earnings »

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