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BGNE

BeiGene

$97.72

-0.13 (-0.13%)

06:02
01/02/18
01/02
06:02
01/02/18
06:02

BeiGene initiates Phase 3 trial of tislelizumab

BeiGene announced that in December 2017 the first patient was dosed in a global Phase 3 clinical trial of tislelizumab, an investigational anti-PD-1 antibody, in patients with previously untreated advanced hepatocellular carcinoma. Along with two pivotal Phase 2 trials in China in relapsed/refractory classical Hodgkin lymphoma and urothelial cancer, and a global Phase 3 trial in patients with non-small cell lung cancer, tislelizumab is now being evaluated in pivotal trials in four distinct indications. The Phase 3, open-label, multi-center, randomized trial is designed to compare the efficacy and safety of tislelizumab versus sorafenib as a potential first-line treatment in patients with unresectable HCC. Approximately 640 patients will be enrolled at approximately 110 cancer centers in China, the United States, Japan, the United Kingdom, Germany, Spain, Czech Republic, France, and Italy. Patients will be randomized to receive either tislelizumab at 200 mg every three weeks or sorafenib at 400 mg twice daily. The trial's primary endpoint is overall survival, and secondary endpoints include overall response rate, progression free survival, duration of response, time to progression, health-related quality of life, disease control rate, clinical benefit rate, and safety profile.

BGNE BeiGene
$97.72

-0.13 (-0.13%)

09/11/17
MAXM
09/11/17
NO CHANGE
MAXM
BeiGene data, Celgene deal closing positive, says Maxim
Maxim analyst Gabrielle Zhou says that preliminary data on a Phase 1/II trial of BeiGene's (BGNE) BGB-290 in patients with advanced solid tumors, including epithelial ovarian cancer, or EOC, showed that the drug has "a similar, if not superior anti-tumor effect compared to other PARP inhibitors in patients with EOC and other solid tumors." Zhou adds that the closing of the company's deal with Celgene (CELG) is also positive. The analyst raised her price target on BeiGene to $77 from $73 and keeps a Buy rating on the stock.
09/29/17
MAXM
09/29/17
NO CHANGE
MAXM
BeiGene price target raised to $120 from $77 at Maxim
Maxim analyst Gabrielle Zhou raised her price target on BeiGene after the company announced preliminary data from its ongoing Phase I/II study of BGBA317 in patients with solid tumors. The analyst says that the drug "has shown signals of efficacy in difficult to treat cancer types." She raised her out-year estimates for the drug and keeps a Buy rating on the stock.
11/14/17
BARD
11/14/17
DOWNGRADE
BARD
Neutral
BeiGene downgraded to Neutral from Outperform at Baird
11/14/17
BARD
11/14/17
DOWNGRADE
Target $83
BARD
Neutral
BeiGene downgraded to Neutral at Baird
As previously reported, Baird analyst Brian Skorney downgraded BeiGene to Neutral from Outperform. He continues to believe the lead assets are strong and that each is looking at a substantial commercial opportunity, but based on current valuation he is moving to the sidelines. Given the recent run-up, the stock already reflects a high probability of success for the company's assets, said Skorney, who raised his price target to $83 from $58 on BeiGene shares.

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CREE

Cree

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CBOE

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RIG

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MET

MetLife

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CVE

Cenovus Energy

$10.43

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UTX

United Technologies

$135.52

0.31 (0.23%)

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AGN

Allergan

$187.32

-0.83 (-0.44%)

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Allergan call volume above normal and directionally bullish »

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VZ

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$53.23

-0.235 (-0.44%)

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CHFN

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SKYAY

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$NSD

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$NYE

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HPE

HP Enterprise

$16.46

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UAL

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RHHBY

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SQ

Square

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