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PLX

Protalix

$0.66

-0.0089 (-1.33%)

07:08
01/02/18
01/02
07:08
01/02/18
07:08

Protalix reports 'positive' interim data from OPRX-106 phase II clinical trial

Protalix BioTherapeutics announced interim data from the first 14 patients that completed, to date, the company's phase II clinical trial of OPRX-106 in patients with ulcerative colitis. The phase II clinical trial is a randomized, open label, 2-arm study of OPRX-106 in patients with active mild to moderate ulcerative colitis. A total of 24 patients were enrolled and randomized to receive 2 mg or 8 mg of OPRX-106, administered orally, once daily, for 8 weeks. The first 14 patients have completed the study, and four patients are currently in treatment and follow-up. The trial evaluated key efficacy endpoints including clinical response and remission utilizing the Mayo score, as well as safety and pharmacokinetics. Data generated from the first 14 patients who completed the study demonstrates that 57% of the patients achieved clinical response and 36% achieved clinical remission at week 8. In the rectal bleeding analysis, a sub category of the Mayo score, 79% of those patients show an improvement. In addition, the majority of those patients show improvement in the study's additional efficacy endpoints, with 86% of the patients achieved an improvement in calprotectin, a protein biomarker present in the feces indicating intestinal inflammation, and 64% have an improved Geboes score, a histopathological scoring for the assessment of disease activity in ulcerative colitis. The company expects to report full results from this study by the end of the first quarter of 2018.

PLX Protalix
$0.66

-0.0089 (-1.33%)

10/19/17
JEFF
10/19/17
NO CHANGE
Target $2.1
JEFF
Buy
Protalix deal with Chiesi removes funding overhang, says Jefferies
Jefferies analyst Peter Welford says Protalix BioTherapeutics' Fabry deal with Chiesi is earlier than expected with better economics than he anticipated. The upfront payment and research and development funding remove the risk of a cash shortfall, Welford tells investors in a research note. He raised his price target for Protalix shares to $2.10 from $1.80 and keeps a Buy rating on the name.
04/17/17
RODM
04/17/17
NO CHANGE
Target $5
RODM
Buy
Protalix price target raised to $5 from $4 at Rodman & Renshaw
Rodman & Renshaw analyst Raghuram Selvaraju raised his price target for Protalix BioTherapeutics to $5 after the company released top-line data from a small proof-of-concept study of its cystic fibrosis drug, AIR DNase. The analyst sees potential for AIR DNase to demonstrate a viable competitive profile in CF patients in future clinical trials. He keeps a Buy rating on the shares.

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Morgan Stanley

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BNY Mellon

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ARNA

Arena Pharmaceuticals

$34.36

0.48 (1.42%)

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Rosehill Resources

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Hess Corp.

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OXY

Occidental Petroleum

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JUNO

Juno Therapeutics

$69.25

23.65 (51.86%)

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Downgrade
Juno Therapeutics rating change at Citi »

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Worldpay

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FRAC

Keane Group

$18.51

0.63 (3.52%)

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Keane Group 13.3M share Secondary priced at $18.25 »

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INTC

Intel

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1.25 (2.90%)

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Intel says issued firmware updates for 90% of CPUs in past vie years »

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TOSBF

Toshiba, also use TOSYY

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Toshiba, also use TOSBF

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Periodicals
Toshiba's Westinghouse to forgo bankruptcy, Reuters reports »

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BAM

Brookfield

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RDS.A

Royal Dutch Shell

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, RDS.B

Royal Dutch Shell

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Periodicals
Shell, BP each agree to purchase Libyan oil, Bloomberg reports »

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Royal Dutch Shell

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Royal Dutch Shell

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BP

BP

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AAPL

Apple

$179.10

2.91 (1.65%)

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Trump says Apple investments 'huge win for American workers' »

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MPVD

Mountain Province Diamonds

$2.83

0.075 (2.73%)

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Mountain Province Diamonds provides update on Gahcho Kue Mine exploration »

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Walter Investment

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0.0347 (4.81%)

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TM

Toyota

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, KBSTY

Kobe Steel

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Toyota not affected by Kobe Steel false data scandal, Nikkei reports »

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Toyota

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CBOE

Cboe Global Markets

$131.52

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Bitcoin

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Cboe conducts first settlement of Cboe bitcoin futures »

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BTC

Bitcoin

BITCOIN

Bitcoin

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GWRE

Guidewire

$75.64

0.19 (0.25%)

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Guidewire director sells 6,000 common shares »

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AAPL

Apple

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Recommendations
Apple analyst commentary at Piper Jaffray »

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OBE

Obsidian Energy

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-0.03 (-2.42%)

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SN

Sanchez Energy

$5.81

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Breaking Hot Stocks news story on Sanchez Energy »

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NTDOY

Nintendo

$51.53

1.55 (3.10%)

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Nintendo announces Nintendo Labo accessories for Switch consoles »

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  • 17

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PTC

PTC

$66.70

1.41 (2.16%)

, ESIO

Electro Scientific

$22.01

1.91 (9.50%)

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On The Fly: After Hours Movers »

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PTC

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ESIO

Electro Scientific

$22.01

1.91 (9.50%)

NEOT

Neothetics

$1.92

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PLXS

Plexus

$64.36

0.59 (0.93%)

AA

Alcoa

$56.99

0.75 (1.33%)

SLM

Sallie Mae

$11.49

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ARWR

Arrowhead

$5.72

0.12 (2.14%)

PRTK

Paratek Pharmaceuticals

$17.68

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IIPR

Innovative Industrial Properties

$31.30

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ECC

Eagle Point Credit

$19.13

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AGIO

Agios Pharmaceuticals

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BTU

Peabody Energy

$40.00

0.42 (1.06%)

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Breaking Hot Stocks news story on Peabody Energy »

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MLNX

Mellanox

$64.30

-0.45 (-0.69%)

17:12
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Starboard to nominate nine directors for election at Mellanox »

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