Breaking News Instant updates and real-time market news.

FPRX

Five Prime

$22.49

0.57 (2.60%)

16:06
01/02/18
01/02
16:06
01/02/18
16:06

Five Prime initiates patient dosing in Phase 1 trial of FPA144

Five Prime Therapeutics announced that on December 27, 2017, the company initiated dosing in the Phase 1 portion of the FIGHT Phase 1/3 clinical trial of FPA144, an isoform-selective anti-FGF receptor 2b antibody, in combination with chemotherapy in patients with previously untreated, advanced gastric or gastroesophageal cancer. The open label Phase 1 portion of the trial will evaluate ascending doses of FPA144 in combination with the modified FOLFOX6 regimen to identify a recommended dose for Phase 3. Endpoints include safety, tolerability, and pharmacokinetic and pharmacodynamics parameters. Approximately 21 patients with unresectable, locally advanced, or metastatic gastrointestinal cancer will be enrolled during the Phase 1 portion of the FIGHT trial. FGFR2 status will be tested retrospectively but is not a requirement for enrollment. This safety lead-in portion of the study is designed to support the Phase 3 portion of the trial, which Five Prime expects to transition to in mid-2018. Five Prime designed the randomized, controlled Phase 3 portion of the trial to serve as a global registrational study. The FIGHT trial will evaluate FPA144 plus mFOLFOX6 versus placebo plus mFOLFOX6 in approximately 550 patients with advanced gastric or gastroesophageal cancer whose tumors overexpress FGFR2b or have FGFR2 gene amplification. Five Prime will use immunohistochemistry and circulating tumor DNA tests to identify patients who would be eligible for inclusion in the trial. The primary Phase 3 endpoint is overall survival with progression free survival, objective response rate, and safety as secondary endpoints. The Phase 3 portion of the trial is expected to include sites in the U.S., Europe and Asia, including China and Japan, where the incidence of gastric cancer is high.

FPRX Five Prime
$22.49

0.57 (2.60%)

11/07/17
SBSH
11/07/17
NO CHANGE
Target $65
SBSH
Buy
Citi says data puts safety of Five Prime's cabiralizumab in question
The key point of today's abstract was 43% G3-5 toxicity related to Five Prime Therapeutics' cabiralizumab, which puts the safety of the drug in question, Citi analyst Robyn Karnauskas tells investors in a research note. The analyst, who notes the data do show some durable activity, does not know at what dose the safety issues occurred. It remains unclear at this point if the activity being seen is due to checkpoint or cabiralizumab's contribution, Karnauskas writes. She models a 35% probability to the cabiralizumab program, which contributes $34 to her price target of $65. The analyst has a Buy rating on Five Prime. The stock is down 34% to $28.67.
11/07/17
JEFF
11/07/17
NO CHANGE
Target $52
JEFF
Buy
Five Prime data not as strong as expected, says Jefferies
Jefferies analyst Eun Yang says the 10% overall response rate with Five Prime Therapeutics' cabiralizumab plus Opdivo in second-line pancreatic cancer is lower than expected and the six-month disease control rate of 13%. The data are "not as strong as we like to see," but compares reasonably to chemo combo in second-line pancreatic cancer, Yang tells investors in a research note. The analyst has a Buy rating on Five Prime Therapeutics with a $52 price target. The stock in midday trading is down 34% to $28.69.
11/08/17
LEER
11/08/17
NO CHANGE
LEER
Outperform
Leerink sees Five Prime recovering some of yesterday's losses
After hosting an investor call to obtain additional information on the efficacy and safety profile of cabiralizumab in pancreatic cancer, Leerink analyst Michael Schmidt expects shares Five Prime Therapeutics (FPRX) will recover some of the losses from yesterday. The efficacy observed in yesterday's data look "quite promising," while safety looks very similar to what has been seen in Opdivo monotherapy trials historically, Schmidt tells investors in a research note. He notes that Five Prime partner Bristol-Myers (BMY) remains highly engaged in the cabiralizumab program. The analyst maintains an Outperform rating on Five Prime shares. The stock in midday trading is up 15%, or $3.85, to $29.71.
11/13/17
NOMU
11/13/17
NO CHANGE
Target $94
NOMU
Buy
Five Prime recent selloff looks unfounded, says Nomura Instinet
Nomura Instinet analyst Christopher Marai believes the cabira+nivo data has been taken out of context and that the recent selloff in shares of Five Prime Therapeutics looks unfounded. The data highlight "remarkable durable responses in patients not expected to respond," Marai tells investors in a research note. He points out that the IDO inhibitor epacadostat routinely only results in 10% benefit in overall response rate. Marai keeps a Buy rating on Five Prime with a $94 price target.

TODAY'S FREE FLY STORIES

GE

General Electric

$16.96

0.785 (4.85%)

14:30
01/23/18
01/23
14:30
01/23/18
14:30
Options
Heavy trading in GE as shares rally ahead of earnings »

Heavy trading in GE as…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Jan

SNE

Sony

$51.00

0.2 (0.39%)

, AAPL

Apple

$177.00

-1.46 (-0.82%)

14:25
01/23/18
01/23
14:25
01/23/18
14:25
Downgrade
Sony, Apple rating change  »

Sony downgraded to…

SNE

Sony

$51.00

0.2 (0.39%)

AAPL

Apple

$177.00

-1.46 (-0.82%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jan

  • 01

    Feb

EXAS

Exact Sciences

$48.49

0.67 (1.40%)

14:25
01/23/18
01/23
14:25
01/23/18
14:25
Options
EXACT Sciences call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 26

    Feb

MAT

Mattel

$16.09

-0.05 (-0.31%)

, HAS

Hasbro

$90.86

-1.7 (-1.84%)

14:22
01/23/18
01/23
14:22
01/23/18
14:22
Hot Stocks
Breaking Hot Stocks news story on Mattel, Hasbro »

Mattel, Hasbro rally to…

MAT

Mattel

$16.09

-0.05 (-0.31%)

HAS

Hasbro

$90.86

-1.7 (-1.84%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 01

    Feb

  • 20

    Feb

  • 20

    Feb

FB

Facebook

$185.37

4.08 (2.25%)

14:18
01/23/18
01/23
14:18
01/23/18
14:18
Hot Stocks
Facebook CMO leaving to advise other companies, help Democratic Party »

In a status update, Gary…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 31

    Jan

  • 07

    Feb

  • 28

    Feb

$NSD

NASDAQ Market Internals

14:17
01/23/18
01/23
14:17
01/23/18
14:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

$NYE

NYSE Market Internals

14:16
01/23/18
01/23
14:16
01/23/18
14:16
Technical Analysis
NYSE market internals summary »

Volume is average for…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

W

Wayfair

$89.35

-1.29 (-1.42%)

14:15
01/23/18
01/23
14:15
01/23/18
14:15
Options
Wayfair put volume heavy and directionally bearish »

Bearish flow noted in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Feb

TWTR

Twitter

$22.84

-0.5 (-2.14%)

14:13
01/23/18
01/23
14:13
01/23/18
14:13
Recommendations
Twitter analyst commentary  »

Noto departure…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 07

    Feb

  • 08

    Feb

  • 28

    Feb

AAPL

Apple

$177.00

-1.46 (-0.82%)

14:10
01/23/18
01/23
14:10
01/23/18
14:10
Periodicals
KGI's Kuo says Apple's next iPhone to have no 3D touch, MacRumors reports »

Apple may launch a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 01

    Feb

SNE

Sony

$51.80

0.995 (1.96%)

14:10
01/23/18
01/23
14:10
01/23/18
14:10
Downgrade
Sony rating change  »

Sony downgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jan

14:10
01/23/18
01/23
14:10
01/23/18
14:10
General news
U.S. equities cooled off from record highs »

U.S. equities cooled off…

BTC

Bitcoin

, BITCOIN

Bitcoin

14:09
01/23/18
01/23
14:09
01/23/18
14:09
Hot Stocks
Stripe says ending Bitcoin support »

Tom Karlo, Stripe's…

BTC

Bitcoin

BITCOIN

Bitcoin

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

REG

Regency Centers

$64.46

0.15 (0.23%)

14:08
01/23/18
01/23
14:08
01/23/18
14:08
Hot Stocks
Regency Centers acquires Whole Foods Market-anchored center in New Jersey »

Regency Centers …

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 09

    Feb

TEVA

Teva

$20.80

-0.22 (-1.05%)

, JNJ

Johnson & Johnson

$142.63

-5.51 (-3.72%)

14:06
01/23/18
01/23
14:06
01/23/18
14:06
Hot Stocks
NYC sues drug manufacturers, distributors over opioid epidemic »

New York City Mayor Bill…

TEVA

Teva

$20.80

-0.22 (-1.05%)

JNJ

Johnson & Johnson

$142.63

-5.51 (-3.72%)

ENDP

Endo

$7.31

0.2 (2.81%)

MCK

McKesson

$171.56

-1.405 (-0.81%)

CAH

Cardinal Health

$73.46

-0.05 (-0.07%)

ABC

AmerisourceBergen

$102.96

0.3 (0.29%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 24

    Jan

  • 01

    Feb

  • 06

    Feb

  • 08

    Feb

  • 16

    Feb

  • 08

    Mar

SHLD

Sears

$3.45

-0.18 (-4.96%)

14:05
01/23/18
01/23
14:05
01/23/18
14:05
Hot Stocks
Fitch downgrades Sears Holdings to 'C' on distressed debt exchange announcement »

Fitch Ratings has…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

FOLD

Amicus

$15.97

0.07 (0.44%)

14:05
01/23/18
01/23
14:05
01/23/18
14:05
Options
Amicus call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

NSC

Norfolk Southern

$150.81

-0.66 (-0.44%)

14:03
01/23/18
01/23
14:03
01/23/18
14:03
Hot Stocks
Breaking Hot Stocks news story on Norfolk Southern »

Norfolk Southern trading…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Jan

DIS

Disney

$110.10

-1 (-0.90%)

14:01
01/23/18
01/23
14:01
01/23/18
14:01
Hot Stocks
Disney to give over 125,000 employees one-time $1,000 cash bonus »

Disney chairman and CEO…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 06

    Feb

JNJ

Johnson & Johnson

$142.74

-5.4 (-3.65%)

14:00
01/23/18
01/23
14:00
01/23/18
14:00
Hot Stocks
Johnson & Johnson Remicade patent loss upheld on appeal »

The United States Court…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 16

    Feb

  • 08

    Mar

NVS

Novartis

$87.03

0.03 (0.03%)

, CMCSA

Comcast

$42.89

0.39 (0.92%)

13:59
01/23/18
01/23
13:59
01/23/18
13:59
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

NVS

Novartis

$87.03

0.03 (0.03%)

CMCSA

Comcast

$42.89

0.39 (0.92%)

GE

General Electric

$16.87

0.7034 (4.35%)

UTX

United Technologies

$135.42

0.2064 (0.15%)

ABT

Abbott

$59.32

-0.2501 (-0.42%)

GD

General Dynamics

$207.58

-0.62 (-0.30%)

ITW

Illinois Tool Works

$172.75

-0.645 (-0.37%)

NSC

Norfolk Southern

$150.90

-0.57 (-0.38%)

BHGE

Baker Hughes

$35.81

0.26 (0.73%)

PGR

Progressive

$57.18

-1.04 (-1.79%)

RCL

Royal Caribbean

$127.33

-1.37 (-1.06%)

SWK

Stanley Black & Decker

$174.31

-0.92 (-0.53%)

ROK

Rockwell Automation

$206.01

2.075 (1.02%)

NTRS

Northern Trust

$107.43

0.94 (0.88%)

GWW

Grainger

$230.43

0.57 (0.25%)

ROL

Rollins

$47.90

0.02 (0.04%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 08

    Feb

  • 16

    Feb

  • 02

    Mar

  • 23

    Apr

  • 17

    May

TXN

Texas Instruments

$119.44

2.61 (2.23%)

, COF

Capital One

$105.09

-0.4 (-0.38%)

13:59
01/23/18
01/23
13:59
01/23/18
13:59
Earnings
Notable companies reporting after market close »

Notable companies…

TXN

Texas Instruments

$119.44

2.61 (2.23%)

COF

Capital One

$105.09

-0.4 (-0.38%)

UAL

United Continental

$77.39

0.52 (0.68%)

TSS

TSYS

$83.64

-0.11 (-0.13%)

NAVI

Navient

$13.52

-0.08 (-0.59%)

CREE

Cree

$36.69

0.4 (1.10%)

FUL

H.B. Fuller

$55.11

0.22 (0.40%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 24

    Jan

  • 24

    Jan

  • 21

    Mar

CMCSA

Comcast

$42.89

0.39 (0.92%)

13:57
01/23/18
01/23
13:57
01/23/18
13:57
Technical Analysis
Technical Earnings Preview: Comcast in stable price channel ahead of news »

Shares have been trading…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Jan

WHR

Whirlpool

$172.58

5.93 (3.56%)

, SSNLF

Samsung

13:50
01/23/18
01/23
13:50
01/23/18
13:50
Hot Stocks
Trump Effect: Whirlpool, solar stocks moving after new import tariffs »

Shares of Whirlpool (WHR)…

WHR

Whirlpool

$172.58

5.93 (3.56%)

SSNLF

Samsung

JKS

JinkoSolar

$21.74

-1.63 (-6.97%)

JASO

JA Solar

$7.46

-0.01 (-0.13%)

FSLR

First Solar

$68.96

-1.07 (-1.53%)

TSLA

Tesla

$351.56

1.54 (0.44%)

RUN

Sunrun

$6.04

0.1 (1.68%)

VSLR

Vivint Solar

$3.78

0.225 (6.34%)

SPWR

SunPower

$8.72

0.07 (0.81%)

CSIQ

Canadian Solar

$15.77

-0.03 (-0.19%)

YGE

Yingli Green Energy

$1.82

-0.0699 (-3.70%)

SEDG

SolarEdge

$34.75

-0.45 (-1.28%)

ENPH

Enphase Energy

$1.97

0.02 (1.03%)

SKYS

Sky Solar

$1.21

-0.12 (-9.02%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jan

  • 30

    Jan

  • 14

    Feb

  • 26

    Feb

CCL

Carnival

$69.03

0.17 (0.25%)

13:50
01/23/18
01/23
13:50
01/23/18
13:50
Options
Carnival Cruise weekly call buyer as shares tick higher »

Carnival Cruise weekly…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.