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REGN

Regeneron

$385.10

2.15 (0.56%)

, SNY

Sanofi

$44.67

0.77 (1.75%)

07:21
01/08/18
01/08
07:21
01/08/18
07:21

Regeneron, Sanofi to expand investment for Cemiplimab, Dupilumab programs

Regeneron (REGN) and Sanofi (SNY) will accelerate and expand investment for the clinical development of the PD-1 antibody cemiplimab in oncology, and the IL-4/IL-13 pathway-blocking antibody dupilumab in Type 2 allergic diseases. Both of these breakthrough therapies have the potential to benefit a number of different patient populations, and this strategic investment will enable the companies to evaluate cemiplimab and dupilumab in broader clinical development programs. Under the terms of the expansion, the investment in cemiplimab will be increased to a minimum of $1.64B, an increase of approximately $1B over the initial 2015 agreement, and Sanofi and Regeneron will continue to equally fund cemiplimab development. The companies will also continue their investment in other immuno-oncology programs under their existing Immuno-oncology Discovery Agreement. Investigational cemiplimab is being studied as monotherapy and in combination with other therapies in a wide range of cancers including advanced skin cancers, non-small cell lung cancer, cervical cancer and lymphomas, with more studies in other indications planned to begin in 2018. The companies expect to submit U.S. and EU regulatory applications for cemiplimab in advanced cutaneous squamous cell carcinoma in the first quarter of 2018. The additional investment in the dupilumab development program will help accelerate planned new studies in chronic obstructive pulmonary disease, peanut allergy and grass allergy, as well as in patients who have multiple allergic conditions. These areas are in addition to ongoing dupilumab clinical development in pediatric atopic dermatitis, pediatric asthma, eosinophilic esophagitis and nasal polyposis. Dupixent is approved for the treatment of adults with moderate-to-severe atopic dermatitis in the U.S. and EU, and a U.S. supplemental biologics license application was submitted for uncontrolled, persistent asthma for patients aged 12 and over in the fourth quarter of 2017. The additional investment will also accelerate and expand development of REGN3500, an IL-33 antibody, with studies expected to be conducted in atopic dermatitis, asthma and chronic obstructive pulmonary disease. The increased funding for dupilumab and REGN3500 will be pursuant to the existing Antibody License and Collaboration Agreement between the companies.

REGN

Regeneron

$385.10

2.15 (0.56%)

SNY

Sanofi

$44.67

0.77 (1.75%)

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REGN Regeneron
$385.10

2.15 (0.56%)

12/18/17
SBSH
12/18/17
NO CHANGE
SBSH
Citi downgrades stance on large-cap Biotechnology to Neutral
Citi analyst Robyn Karnauskas downgraded her view on the large-cap Biotechnology sector to Neutral heading into 2018. The negative sentiment on the space may not change in the near term as valuations are not cheap and there are few catalysts in 2018, Karnauskas tells investors in a research note. Valuations in the group do not appear cheap when you look at the growth profile of large-cap biotech versus the broader market, the analyst contends. She believes the "only way out for the sector is innovation," and prefers to move to the sidelines "until we see something there." Where Karnauskas does see upside in 2018 is in shares of Alexion (ALXN), BioMarin (BMRN), Vertex (VRTX) and Tesaro (TSRO).
12/18/17
MSCO
12/18/17
NO CHANGE
MSCO
Morgan Stanley sees opportunities in biotech amid 'limited' investor conviction
With clinical catalysts in large-cap Biotechnology limited to only five key Phase III readouts - three of which are from Alexion (ALXN) - investors are describing their 2018 picks in the space as the "least worst" of the group, according to Morgan Stanley analyst Matthew Harrison. However, he believes this lack of conviction creates real opportunity for outsized moves in 2018, with Amgen (AMGN) identified by Harrison as the biggest potential beneficiary of M&A given "its likely newfound access" to about $39B in offshore cash. Other biotech names the analyst highlights on the up side include Biogen (BIIB), BioMarin (BMRN), Biohaven (BHVN) and Sarepta (SRPT). Meanwhile, Harrison highlights his concerns about potential downside for BioVerativ (BIVV) and Innoviva (INVA), on both of which he keeps Underweight ratings.
12/28/17
ARGS
12/28/17
NO CHANGE
Target $470
ARGS
Buy
Regeneron price target lowered to $470 from $540 at Argus
Argus analyst Jasper Hellweg lowered his price target on Regeneron (REGN) to $470 to reflect some of the recent weakness in the stock, but keeps his Buy rating. Hellweg says that while the company's growth has slowed in recent years, it continues to benefit from sales of Eylea, collaboration agreements with Sanofi (SNY) and Bayer (BAYRY) as well as a strong new product pipeline.
12/29/17
PIPR
12/29/17
NO CHANGE
PIPR
Biotech fund outflows continue, says Piper Jaffray
For the weekly period ending Wednesday, December 27, healthcare/biotech funds saw $338M in net outflows, representing a 0.58% decrease in assets, Piper Jaffray analyst Christopher Raymond tells investors in a research note. This marks the seventh straight negative week and the eleventh week of outflows in the past 12 weeks, the analyst points out in a research note titled "Ending 2017 on a Down Note: Biotech Outflows Continue."
SNY Sanofi
$44.67

0.77 (1.75%)

12/01/17
MSCO
12/01/17
DOWNGRADE
MSCO
Underweight
Sanofi downgraded to Underweight from Overweight at Morgan Stanley
12/06/17
BOFA
12/06/17
DOWNGRADE
BOFA
Neutral
Sanofi downgraded to Neutral from Buy at BofA/Merrill
BofA/Merrill analyst Graham Perry downgraded Sanofi to Neutral citing valuation and lack of earnings momentum into 2018.
01/07/18
PIPR
01/07/18
NO CHANGE
Target $182
PIPR
Overweight
Deal with Sanofi 'good' for Alnylam, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff notes that under a strategic alliance restructuring, Alnylam (ALNY) is gaining global rights to patisiran and ALN-TTRsc02, and Sanofi (SNY) gains global fitusiran rights. The analyst anticipates patisiran FDA approval in mid'18 and in Europe in late'18. Tenthoff views this as a "good deal" for Alnylam as the company will control global TTR amyloidosis development and commercialization. He reiterates an Overweight rating and $182 price target on Alnylam shares.

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POST

Post Holdings

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ABMD

Abiomed

$394.49

0.04 (0.01%)

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-0.58 (-0.53%)

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PRAH

PRA Health

$81.19

0.33 (0.41%)

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$81.19

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WYN

Wyndham

$107.98

-0.58 (-0.53%)

, MSCC

Microsemi

$68.74

0.005 (0.01%)

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Hot Stocks
Breaking Hot Stocks news story on Wyndham, Microsemi »

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ABMD

Abiomed

$394.49

0.04 (0.01%)

, WYN

Wyndham

$107.98

-0.58 (-0.53%)

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Breaking Hot Stocks news story on Abiomed, Wyndham »

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PCG

PG&E

$44.67

0.84 (1.92%)

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CA Forestry Dept rules PG&E equipment responsible for wildfires, Bloomberg says »

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FARM

Farmer Bros.

$28.50

0.15 (0.53%)

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NDLS

Noodles & Company

$8.90

-0.35 (-3.78%)

17:07
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Breaking Syndicate news story on Noodles & Company »

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WIN

Windstream

$1.22

-0.125 (-9.29%)

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NDLS

Noodles & Company

$8.90

-0.35 (-3.78%)

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EPD

Enterprise Products

$27.87

-0.12 (-0.43%)

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INO

Inovio

$4.89

0.06 (1.24%)

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RCII

Rent-A-Center

$10.14

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AKER

Akers Biosciences

$0.59

0.0086 (1.48%)

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DHCP

Ditech

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0.37 (5.94%)

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GPS

Gap

$28.15

-4.82 (-14.62%)

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$55.97

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On The Fly: Top stock stories for Friday »

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FL

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Herbalife Nutrition

$48.76

-5.09 (-9.45%)

IEP

Icahn Enterprises

$69.41

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FCAU

Fiat Chrysler

$21.82

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DGX

Quest Diagnostics

$105.89

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UNH

UnitedHealth

$244.96

2.23 (0.92%)

ROST

Ross Stores

$77.35

-5.6 (-6.75%)

ADSK

Autodesk

$132.80

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AAL

American Airlines

$44.89

1.34 (3.08%)

LUV

Southwest

$52.86

1.65 (3.22%)

DAL

Delta Air Lines

$55.89

1.48 (2.72%)

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16:30
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Options
Preliminary option volume of 16.4M today »

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VTL

Vital Therapies

$5.65

-0.475 (-7.76%)

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VTL

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$5.65

-0.475 (-7.76%)

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LNC

Lincoln National

$68.89

-0.555 (-0.80%)

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DGLY

Digital Ally

$2.63

0.075 (2.94%)

16:23
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SNGX

Soligenix

$1.58

-0.005 (-0.32%)

16:23
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HF

HFF Inc.

$35.34

0.08 (0.23%)

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VIX

Volatility Index S&P 500 Options

$0.00

(0.00%)

16:20
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