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AXON

Axovant Sciences

$5.37

0.13 (2.48%)

07:26
01/08/18
01/08
07:26
01/08/18
07:26

Axovant says intepirdine did not meet primary efficacy endpoints in studies

Axovant Sciences announced that its investigational drug intepirdine did not meet its primary efficacy endpoints in the Phase 2b HEADWAY and pilot Phase 2 Gait and Balance studies. Separately, the Company's investigational drug nelotanserin met its prespecified primary endpoint of safety in the pilot Phase 2 Visual Hallucination study. In addition, in this exploratory study, nelotanserin treatment resulted in a positive trend in efficacy in a prespecified intent to treat analysis of the motor function scale, the Unified Parkinson's Disease Rating Scale Part III. Nelotanserin treatment also resulted in an efficacy signal in a post-hoc subset analysis of patients with higher baseline scores on the Scale for the Assessment of Positive Symptoms - Parkinson's Disease.

  • 08

    Jan

AXON Axovant Sciences
$5.37

0.13 (2.48%)

09/27/17
HCWC
09/27/17
NO CHANGE
Target $11
HCWC
Buy
H.C. Wainwright reiterates Buy on Axovant, says look beyond Mindset
Following the failure in Alzheimer's, H.C. Wainwright analyst Andrew Fein encourages investors to look beyond the Mindset trial and focus on the four compounds Axovant Sciences has in the clinic. He believes readouts later this year in Lewy bodies and Parkinson's disease dementia may comprise the main value drivers for Axovant moving forward. The company's core competence resides in its ability to identify and in-license underappreciated and undervalued assets, Fein tells investors in a research note partially titled "'Skyfall' is Not the End." He lowered his price target on the shares to $11 from $35 and reiterates a Buy rating on the name.
09/27/17
BARD
09/27/17
DOWNGRADE
Target $6
BARD
Neutral
Axovant Sciences downgraded to Neutral, failure a 'death blow,' says Baird
Baird analyst Brian Skorney downgraded Axovant Sciences to Neutral from Outperform saying the failure of the Phase 3 MINDSET study in Alzheimer's this morning is a "death blow" to his thesis. The analyst removed all Alzheimer's sales for intepirdine of up to $3.5B at peak from his model and slashed Axovant's price target to $6 from $29.
12/21/17
JEFF
12/21/17
DOWNGRADE
Target $6
JEFF
Hold
Axovant Sciences downgraded to Hold from Buy at Jefferies
Jefferies analyst Michael Yee downgraded Axovant Sciences to Hold and cut his price target for the shares to $6 from $12. The company needs "more interesting" in-licensed compounds to renew investor interest in 2018 and to demonstrate the new CEO can drive shareholder value, Yee tells investors in a research note. The analyst views the stock's risk/reward as balanced at current levels.
12/21/17
12/21/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. PG&E (PCG) downgraded to Sector Perform from Outperform at RBC Capital with analyst Shelby Tucker stating that the company's "unexpected" decision to suspend its dividend suggests greater risk than he had assumed regarding the regulatory treatment of the California wildfires in October. 2. ConocoPhillips (COP) downgraded to Outperform from Focus List at Scotia Howard Weil. 3. Axovant Sciences (AXON) downgraded to Hold from Buy at Jefferies with analyst Michael Yee saying the company needs "more interesting" in-licensed compounds to renew investor interest in 2018 and to demonstrate the new CEO can drive shareholder value. 4. Lazard (LAZ) downgraded to Neutral from Buy at Buckingham with analyst James Mitchell saying he sees little operating leverage from the tax rate cut and said weakening restructuring revenues will be a drag on growth. 5. SunTrust (STI) downgraded to Neutral from Outperform at Wedbush with analyst Peter Winter citing valuation with the shares up 19% year-to-date. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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