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RVNC

Revance

$34.90

-1 (-2.79%)

08:18
01/08/18
01/08
08:18
01/08/18
08:18

Revance says RT002 has 'positive impact' in Phase 2a study

Revance Therapeutics announced interim 8-week Phase 2a results for its next-generation neuromodulator DaxibotulinumtoxinA for Injection in treating plantar fasciitis, a common debilitating form of foot pain. The trial's primary endpoint, the reduction in the patient-reported visual analog scale for pain at Week 8, showed a robust impact on pain, with a greater than 50% reduction for patients treated with RT002. In the intent-to-treat population, a mean reduction in the VAS score of 54.2% from baseline was achieved with RT002, compared with a 42.6% reduction in the placebo group, which upon further subgroup analysis, was driven primarily by a strong placebo response in the control group at two of the five study sites. While not statistically significant, RT002 did outperform placebo, providing patients with considerable pain relief. Similar numeric trends were seen in the secondary and exploratory endpoints. RT002 appeared to be generally safe and well-tolerated through Week 8. The majority of adverse events in both treatment groups were mild in severity. There were no treatment-related serious adverse events. The most common treatment-related adverse events for RT002 and placebo were injection site pain and muscle weakness both respectively, all of which were classified as mild in severity.

RVNC Revance
$34.90

-1 (-2.79%)

12/08/17
RHCO
12/08/17
NO CHANGE
Target $53
RHCO
Buy
Revance price target raised to $53 from $32 at SunTrust
SunTrust analyst John Boris raised his price target on Revance (RVNC) to $53, saying the company's RT002's clinical data is "de-risked in glabellar lines", offering significant differentiation relative to Allegan's (AGN) Botox. Boris expects GL SAKURA data to be presented in February of 2018, modeling approval by the first half of 2020. The analyst also notes that the RT0002 Phase-2 plantar fasciitis data on track for December and the initiation of Phase 3 cervical dystonia trials for Q2 of next year, keeping his Buy rating on the stock.
12/13/17
CANT
12/13/17
NO CHANGE
Target $50
CANT
Overweight
Cantor sees more positive data from Revance this year
Cantor Fitzgerald analyst Louise Chen reiterates an Overweight rating on Revance Therapeutics with a $50 price target saying the company reported positive results for its Sakura 1 and 2 Phase 3 trials. The analyst expects good data from the company's Phase 2 study in plantar fasciitis at the end of December. Positive results from the plantar fasciitis trial could help establish proof of concept for RT002 in migraine as well as other areas of pain, Chen tells investors in a research note. She sees upward earnings revisions to levels not reflected in sell-side consensus expectations to drive the stock higher.
12/19/17
LEHM
12/19/17
NO CHANGE
Target $40
LEHM
Overweight
Revance price target raised to $40 from $31 at Barclays
Barclays analyst Douglas Tsao raised his price target for Revance Therapeutics (RVNC) to $40 while detailing his 2018 outlook for the U.S. Specialty Pharmaceuticals sector. The analyst keeps an Overweight rating on the shares. Mylan (MYL) is Tsao's top pick for 2018.
01/05/18
WELS
01/05/18
NO CHANGE
Target $245
WELS
Outperform
Allergan has built 'great barrier' around Botox, says Wells Fargo
Wells Fargo analyst David Maris conducted a survey of 25 plastic surgeons and dermatologists to gain insight on the changing neurotoxin landscape. The survey shows Allergan's (AGN) patient and physician loyalty programs and bundling discounts create a "great barrier" around Botox, Maris tells investors in a research note. It is unclear how significant a potential competitor Revance's (RVNC) RT002 could be to Allergan's largest product, the analyst adds. He believes that even with new innovative treatment options, Botox is expected to maintain its dominance in the neurotoxin market. Further, the analyst says that while RT002 showed statistically significant results at week 24 versus placebo, the endpoint doesn't seem not match the FDA's published guidance. Maris wonders if the data will be enough to get a six-month duration claim on the RT002 label, or if Revance is just hoping for an approval and then will point to the duration data. He keeps an Outperform rating on Allergan with a $245 price target.

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UPL

Ultra Petroleum

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PBR

Petrobras

$12.77

-2.335 (-15.46%)

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MSCI Brazil Index

$38.16

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ROST

Ross Stores

$82.95

0.35 (0.42%)

20:46
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BMRN

BioMarin

$88.30

-0.2 (-0.23%)

20:41
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DECK

Deckers Brands

$103.63

0.8 (0.78%)

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DGX

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ZOES

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GPS

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8x8, Inc.

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ADSK

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NTNX

Nutanix

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SPLK

Splunk

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VEEV

Veeva

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0.5 (0.65%)

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FL

Foot Locker

$46.38

1.35 (3.00%)

, HIBB

Hibbett Sports

$28.95

0.6 (2.12%)

20:25
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Earnings
Notable companies reporting before tomorrow's open »

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FL

Foot Locker

$46.38

1.35 (3.00%)

HIBB

Hibbett Sports

$28.95

0.6 (2.12%)

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SNAP

Snap

$10.59

-0.045 (-0.42%)

20:06
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Snap's Send and Request location feature aims to boost privacy, TechCrunch says »

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MDT

Medtronic

$86.94

1.65 (1.93%)

19:52
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MRK

Merck

$59.11

-0.05 (-0.08%)

, ESALY

Eisai

$0.00

(0.00%)

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MRK

Merck

$59.11

-0.05 (-0.08%)

ESALY

Eisai

$0.00

(0.00%)

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MCD

McDonald's

$162.38

0.865 (0.54%)

19:18
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McDonald's sued by customers over unwanted cheese on burgers, Miami Herald says »

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CNI

Canadian National

$83.75

-0.4 (-0.48%)

19:18
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Canadian National rating change at Deutsche Bank »

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EXR

Extra Space Storage

$95.10

1.335 (1.42%)

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Extra Space Storage raises quarterly dividend by 10.3% to 86c per share »

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EWP

MSCI Spain Index ETF

$32.38

-0.075 (-0.23%)

, FXE

Euro Currency Trust

$112.60

0.2 (0.18%)

19:09
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Spain opposition planning no-confidence vote for PM Rajoy, Bloomberg reports »

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EWP

MSCI Spain Index ETF

$32.38

-0.075 (-0.23%)

FXE

Euro Currency Trust

$112.60

0.2 (0.18%)

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SSNLF

Samsung

$0.00

(0.00%)

, AAPL

Apple

$188.18

-0.18 (-0.10%)

18:48
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Periodicals
Breaking Periodicals news story on Samsung, Apple »

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SSNLF

Samsung

$0.00

(0.00%)

AAPL

Apple

$188.18

-0.18 (-0.10%)

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XOM

Exxon Mobil

$80.26

-1.88 (-2.29%)

18:43
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Sonatrach CEO seeks cooperation with Exxon on shale gas, Reuters says »

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UAL

United Continental

$70.47

0.93 (1.34%)

18:39
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United names former FAA chief Jane Garvey chairman, Bloomberg says »

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SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$272.87

-0.5 (-0.18%)

18:35
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Periodicals
U.S. bill would force tech firms to reveal foreign software use, Reuters says »

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SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$272.87

-0.5 (-0.18%)

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EWY

iShares MSCI South Korea Index Fund

$73.49

-0.96 (-1.29%)

, SPY

SPDR S&P 500 ETF Trust

$272.87

-0.5 (-0.18%)

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EWY

iShares MSCI South Korea Index Fund

$73.49

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SPY

SPDR S&P 500 ETF Trust

$272.87

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EWJ

iShares MSCI Japan Index Fund

$60.34

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LMT

Lockheed Martin

$326.46

0.98 (0.30%)

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GXP

Great Plains Energy

$32.77

0.02 (0.06%)

, WR

Westar Energy

$54.59

0.35 (0.65%)

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Great Plains-Westar Energy merger approved by KCC, MPSC »

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GXP

Great Plains Energy

$32.77

0.02 (0.06%)

WR

Westar Energy

$54.59

0.35 (0.65%)

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UAL

United Continental

$70.47

0.93 (1.34%)

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KRNY

Kearny Financial

$14.25

-0.1 (-0.70%)

18:05
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Kearny Financial increases quarterly cash dividend to 4c per share »

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YRD

Yirendai

$28.42

-0.33 (-1.15%)

18:02
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Earnings
Yirendai reports Q1 adjusted income per ADS $1.72, consensus 99c »

Reports Q1 revenue…

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AAPL

Apple

$188.18

-0.18 (-0.10%)

, SSNLF

Samsung

$0.00

(0.00%)

17:59
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Periodicals
Apple wins $539M award from Samsung in patent trial, Bloomberg reports »

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AAPL

Apple

$188.18

-0.18 (-0.10%)

SSNLF

Samsung

$0.00

(0.00%)

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