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RVNC

Revance

$34.90

-1 (-2.79%)

08:18
01/08/18
01/08
08:18
01/08/18
08:18

Revance says RT002 has 'positive impact' in Phase 2a study

Revance Therapeutics announced interim 8-week Phase 2a results for its next-generation neuromodulator DaxibotulinumtoxinA for Injection in treating plantar fasciitis, a common debilitating form of foot pain. The trial's primary endpoint, the reduction in the patient-reported visual analog scale for pain at Week 8, showed a robust impact on pain, with a greater than 50% reduction for patients treated with RT002. In the intent-to-treat population, a mean reduction in the VAS score of 54.2% from baseline was achieved with RT002, compared with a 42.6% reduction in the placebo group, which upon further subgroup analysis, was driven primarily by a strong placebo response in the control group at two of the five study sites. While not statistically significant, RT002 did outperform placebo, providing patients with considerable pain relief. Similar numeric trends were seen in the secondary and exploratory endpoints. RT002 appeared to be generally safe and well-tolerated through Week 8. The majority of adverse events in both treatment groups were mild in severity. There were no treatment-related serious adverse events. The most common treatment-related adverse events for RT002 and placebo were injection site pain and muscle weakness both respectively, all of which were classified as mild in severity.

RVNC Revance
$34.90

-1 (-2.79%)

12/08/17
RHCO
12/08/17
NO CHANGE
Target $53
RHCO
Buy
Revance price target raised to $53 from $32 at SunTrust
SunTrust analyst John Boris raised his price target on Revance (RVNC) to $53, saying the company's RT002's clinical data is "de-risked in glabellar lines", offering significant differentiation relative to Allegan's (AGN) Botox. Boris expects GL SAKURA data to be presented in February of 2018, modeling approval by the first half of 2020. The analyst also notes that the RT0002 Phase-2 plantar fasciitis data on track for December and the initiation of Phase 3 cervical dystonia trials for Q2 of next year, keeping his Buy rating on the stock.
12/13/17
CANT
12/13/17
NO CHANGE
Target $50
CANT
Overweight
Cantor sees more positive data from Revance this year
Cantor Fitzgerald analyst Louise Chen reiterates an Overweight rating on Revance Therapeutics with a $50 price target saying the company reported positive results for its Sakura 1 and 2 Phase 3 trials. The analyst expects good data from the company's Phase 2 study in plantar fasciitis at the end of December. Positive results from the plantar fasciitis trial could help establish proof of concept for RT002 in migraine as well as other areas of pain, Chen tells investors in a research note. She sees upward earnings revisions to levels not reflected in sell-side consensus expectations to drive the stock higher.
12/19/17
LEHM
12/19/17
NO CHANGE
Target $40
LEHM
Overweight
Revance price target raised to $40 from $31 at Barclays
Barclays analyst Douglas Tsao raised his price target for Revance Therapeutics (RVNC) to $40 while detailing his 2018 outlook for the U.S. Specialty Pharmaceuticals sector. The analyst keeps an Overweight rating on the shares. Mylan (MYL) is Tsao's top pick for 2018.
01/05/18
WELS
01/05/18
NO CHANGE
Target $245
WELS
Outperform
Allergan has built 'great barrier' around Botox, says Wells Fargo
Wells Fargo analyst David Maris conducted a survey of 25 plastic surgeons and dermatologists to gain insight on the changing neurotoxin landscape. The survey shows Allergan's (AGN) patient and physician loyalty programs and bundling discounts create a "great barrier" around Botox, Maris tells investors in a research note. It is unclear how significant a potential competitor Revance's (RVNC) RT002 could be to Allergan's largest product, the analyst adds. He believes that even with new innovative treatment options, Botox is expected to maintain its dominance in the neurotoxin market. Further, the analyst says that while RT002 showed statistically significant results at week 24 versus placebo, the endpoint doesn't seem not match the FDA's published guidance. Maris wonders if the data will be enough to get a six-month duration claim on the RT002 label, or if Revance is just hoping for an approval and then will point to the duration data. He keeps an Outperform rating on Allergan with a $245 price target.

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NVS

Novartis

$87.21

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Comcast

$42.44

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Novartis

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CERS

Cerus

$4.33

0.14 (3.34%)

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Cerus to hold a pharmaceutical update conference call »

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XPER

Xperi

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0.35 (1.56%)

19:26
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Xperi to hold a conference call »

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MDR

McDermott

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BDRBF

Bombardier

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Periodicals
Bombardier invokes Embraer in Boeing trade dispute, Globe and Mail says »

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Bombardier

ERJ

Embraer

$24.13

-0.34 (-1.39%)

BA

Boeing

$335.59

-2.41 (-0.71%)

DAL

Delta Air Lines

$59.93

-0.2 (-0.33%)

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GSBC

Great Southern Bancorp

$52.00

0.45 (0.87%)

19:01
01/23/18
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19:01
Earnings
Great Southern Bancorp reports preliminary Q4 EPS 86c, consnesus 83c »

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UUUU

Energy Fuels

$1.72

0.035 (2.08%)

18:48
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18:48
Hot Stocks
Energy Fuels names Mark S. Chalmers president and CEO »

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Breaking General news story  »

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RBS

RBS

$8.46

-0.02 (-0.24%)

18:10
01/23/18
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Periodicals
RBS plans to leave London headquarters by end of 2019, Reuters reports »

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TROX

Tronox

$21.88

0.07 (0.32%)

18:09
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Tronox files lawsuit to prevent FTC from blocking proposed Cristal acquisition »

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UBNK

United Financial

$17.92

-0.03 (-0.17%)

18:00
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United Financial reports Q4 provision for loan losses $2.3M »

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UBNK

United Financial

$17.92

-0.03 (-0.17%)

17:59
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17:59
Earnings
United Financial reports Q4 EPS with items 19c, consensus 30c »

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SPY

SPDR S&P 500 ETF Trust

$283.29

0.6 (0.21%)

, SPX

S&P 500

17:55
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17:55
General news
Breaking General news story on SPDR S&P 500 ETF Trust, S&P 500 »

Senate confirms Jerome…

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SPDR S&P 500 ETF Trust

$283.29

0.6 (0.21%)

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S&P 500

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Federal Reserve Bank of Chicago President participates in a discussion »

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HESM

Hess Midstream Partners

$21.75

0.45 (2.11%)

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Hess Midstream Partners raises quarterly dividend 3.6% to 32.2c per unit »

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GWB

Great Western

$44.29

0.53 (1.21%)

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Great Western announces financial impact resulting from Tax Cuts and Jobs Act »

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ARAY

Accuray

$5.20

0.05 (0.97%)

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TSYS

$83.92

0.17 (0.20%)

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On The Fly: After Hours Movers »

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Accuray

$5.20

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TSYS

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CERS

Cerus

$4.33

0.14 (3.34%)

NTIP

Network-1 Technologies

$2.60

0.1 (4.00%)

GOOG

Alphabet

$1,169.97

14.16 (1.23%)

GOOGL

Alphabet Class A

$1,176.17

12.01 (1.03%)

QGEN

Qiagen

$33.55

0.5 (1.51%)

SIRI

SiriusXM

$5.68

0.03 (0.53%)

VLO

Valero

$98.69

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UAL

United Continental

$77.97

1.1 (1.43%)

NAVI

Navient

$13.44

-0.08 (-0.59%)

CREE

Cree

$35.02

-1.67 (-4.55%)

COF

Capital One

$105.71

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TXN

Texas Instruments

$119.89

0.45 (0.38%)

PBYI

Puma Biotechnology

$90.90

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SIGM

Sigma Designs

$7.00

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FPRX

Five Prime

$22.43

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RCKT

Rocket Pharmaceuticals

$15.19

1.92 (14.47%)

TK

Teekay Corp.

$10.74

0.05 (0.47%)

SBBP

Strongbridge Biopharma

$8.70

0.25 (2.96%)

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UAL

United Continental

$77.97

1.11 (1.44%)

17:25
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Earnings
United Continental sees FY18 EPS $6.50-$8.50, consensus $6.97 »

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17:25
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Conference/Events
The Chicago Council on Global Affairs to hold a panel discussion »

The Chicago Council on…

MULE

MuleSoft

$25.08

-0.31 (-1.22%)

17:21
01/23/18
01/23
17:21
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17:21
Initiation
MuleSoft initiated at Nomura Instinet »

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MDB

MongoDB

$28.83

0.02 (0.07%)

17:19
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17:19
Initiation
MongoDB initiated at Nomura Instinet »

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UAL

United Continental

$77.97

1.1 (1.43%)

17:19
01/23/18
01/23
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17:19
Hot Stocks
Breaking Hot Stocks news story on United Continental »

United sees FY19 and FY20…

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UAL

United Continental

$77.97

1.1 (1.43%)

17:18
01/23/18
01/23
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Hot Stocks
Breaking Hot Stocks news story on United Continental »

United sees FY18 CASM…

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APTI

Apptio

$24.39

0.02 (0.08%)

17:17
01/23/18
01/23
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17:17
Initiation
Apptio initiated at Nomura Instinet »

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VMW

VMware

$137.96

1.27 (0.93%)

17:16
01/23/18
01/23
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17:16
Initiation
VMware initiated at Nomura Instinet »

Nomura starts VMware with…

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