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ADAP

Adaptimmune

$7.71

0.19 (2.53%)

08:25
01/08/18
01/08
08:25
01/08/18
08:25

Adaptimmune announces 'positive' safety data from pilot studies

Adaptimmune Therapeutics announced initial safety data from its two ongoing pilot studies of SPEAR T-cells targeting MAGE-A10, one in non-small cell lung cancer, or NSCLC, and a triple tumor study in bladder, melanoma, and head & neck cancers. To date, 8 patients have each received 100 million transduced MAGE-A10 SPEAR T-cells in the first dose cohorts of both studies. No evidence of toxicity related to off-target binding or alloreactivity has been observed. There have been no reports of neurotoxicity safety events similar to CAR-T cell-related encephalopathy syndrome, or CRES. In the NSCLC study, there has been one serious adverse event of cytokine release syndrome, or CRS, a Grade 4 event that resolved with treatment. This event led to cohort 1 expansion from 3 to 6 patients. No dose limiting toxicities were observed in cohort 1 of the triple tumor study. Following review by the independent safety review committee, or SRC, the decision has been made to escalate to the next dose of 1 billion transduced MAGE-A10 SPEAR T-cells in the triple tumor study. This was the therapeutic threshold dose observed with SPEAR T-cells targeting NY-ESO in the synovial sarcoma pilot study. The decision to escalate in the NSCLC cohort will be reviewed by the SRC following dosing of the 6th patient.

  • 08

    Jan

  • 08

    Jan

ADAP Adaptimmune
$7.71

0.19 (2.53%)

03/17/17
WELS
03/17/17
INITIATION
WELS
Market Perform
Adaptimmune initiated with a Market Perform at Wells Fargo
Wells Fargo analyst Jim Birchenough started Adaptimmune Therapeutics with a Market Perform rating and $5-$7 price target range.

TODAY'S FREE FLY STORIES

HMNY

Helios and Matheson

$8.27

0.19 (2.35%)

14:45
01/23/18
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Helios and Matheson call volume above normal and directionally bullish »

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MAT

Mattel

$16.09

-0.05 (-0.31%)

, HAS

Hasbro

$90.86

-1.7 (-1.84%)

14:42
01/23/18
01/23
14:42
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14:42
Periodicals
Mattel gives CNN no comment on stock jump »

Paul La Monica of CNN…

MAT

Mattel

$16.09

-0.05 (-0.31%)

HAS

Hasbro

$90.86

-1.7 (-1.84%)

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AAPL

Apple

$177.00

-1.46 (-0.82%)

14:41
01/23/18
01/23
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14:41
Recommendations
Apple analyst commentary  »

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GE

General Electric

$16.96

0.785 (4.85%)

14:30
01/23/18
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Heavy trading in GE as shares rally ahead of earnings »

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SNE

Sony

$51.00

0.2 (0.39%)

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Apple

$177.00

-1.46 (-0.82%)

14:25
01/23/18
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14:25
Downgrade
Sony, Apple rating change  »

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SNE

Sony

$51.00

0.2 (0.39%)

AAPL

Apple

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-1.46 (-0.82%)

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EXAS

Exact Sciences

$48.49

0.67 (1.40%)

14:25
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14:25
Options
EXACT Sciences call volume above normal and directionally bullish »

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  • 26

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MAT

Mattel

$16.09

-0.05 (-0.31%)

, HAS

Hasbro

$90.86

-1.7 (-1.84%)

14:22
01/23/18
01/23
14:22
01/23/18
14:22
Hot Stocks
Breaking Hot Stocks news story on Mattel, Hasbro »

Mattel, Hasbro rally to…

MAT

Mattel

$16.09

-0.05 (-0.31%)

HAS

Hasbro

$90.86

-1.7 (-1.84%)

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FB

Facebook

$185.37

4.08 (2.25%)

14:18
01/23/18
01/23
14:18
01/23/18
14:18
Hot Stocks
Facebook CMO leaving to advise other companies, help Democratic Party »

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$NSD

NASDAQ Market Internals

14:17
01/23/18
01/23
14:17
01/23/18
14:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

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$NYE

NYSE Market Internals

14:16
01/23/18
01/23
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01/23/18
14:16
Technical Analysis
NYSE market internals summary »

Volume is average for…

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W

Wayfair

$89.35

-1.29 (-1.42%)

14:15
01/23/18
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14:15
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14:15
Options
Wayfair put volume heavy and directionally bearish »

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  • 22

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TWTR

Twitter

$22.84

-0.5 (-2.14%)

14:13
01/23/18
01/23
14:13
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14:13
Recommendations
Twitter analyst commentary  »

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AAPL

Apple

$177.00

-1.46 (-0.82%)

14:10
01/23/18
01/23
14:10
01/23/18
14:10
Periodicals
KGI's Kuo says Apple's next iPhone to have no 3D touch, MacRumors reports »

Apple may launch a…

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  • 01

    Feb

SNE

Sony

$51.80

0.995 (1.96%)

14:10
01/23/18
01/23
14:10
01/23/18
14:10
Downgrade
Sony rating change  »

Sony downgraded to…

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  • 25

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14:10
01/23/18
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14:10
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14:10
General news
U.S. equities cooled off from record highs »

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BTC

Bitcoin

, BITCOIN

Bitcoin

14:09
01/23/18
01/23
14:09
01/23/18
14:09
Hot Stocks
Stripe says ending Bitcoin support »

Tom Karlo, Stripe's…

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Bitcoin

BITCOIN

Bitcoin

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REG

Regency Centers

$64.46

0.15 (0.23%)

14:08
01/23/18
01/23
14:08
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14:08
Hot Stocks
Regency Centers acquires Whole Foods Market-anchored center in New Jersey »

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  • 09

    Feb

TEVA

Teva

$20.80

-0.22 (-1.05%)

, JNJ

Johnson & Johnson

$142.63

-5.51 (-3.72%)

14:06
01/23/18
01/23
14:06
01/23/18
14:06
Hot Stocks
NYC sues drug manufacturers, distributors over opioid epidemic »

New York City Mayor Bill…

TEVA

Teva

$20.80

-0.22 (-1.05%)

JNJ

Johnson & Johnson

$142.63

-5.51 (-3.72%)

ENDP

Endo

$7.31

0.2 (2.81%)

MCK

McKesson

$171.56

-1.405 (-0.81%)

CAH

Cardinal Health

$73.46

-0.05 (-0.07%)

ABC

AmerisourceBergen

$102.96

0.3 (0.29%)

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SHLD

Sears

$3.45

-0.18 (-4.96%)

14:05
01/23/18
01/23
14:05
01/23/18
14:05
Hot Stocks
Fitch downgrades Sears Holdings to 'C' on distressed debt exchange announcement »

Fitch Ratings has…

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FOLD

Amicus

$15.97

0.07 (0.44%)

14:05
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01/23
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14:05
Options
Amicus call volume above normal and directionally bullish »

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NSC

Norfolk Southern

$150.81

-0.66 (-0.44%)

14:03
01/23/18
01/23
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14:03
Hot Stocks
Breaking Hot Stocks news story on Norfolk Southern »

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  • 24

    Jan

DIS

Disney

$110.10

-1 (-0.90%)

14:01
01/23/18
01/23
14:01
01/23/18
14:01
Hot Stocks
Disney to give over 125,000 employees one-time $1,000 cash bonus »

Disney chairman and CEO…

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  • 06

    Feb

JNJ

Johnson & Johnson

$142.74

-5.4 (-3.65%)

14:00
01/23/18
01/23
14:00
01/23/18
14:00
Hot Stocks
Johnson & Johnson Remicade patent loss upheld on appeal »

The United States Court…

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  • 23

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NVS

Novartis

$87.03

0.03 (0.03%)

, CMCSA

Comcast

$42.89

0.39 (0.92%)

13:59
01/23/18
01/23
13:59
01/23/18
13:59
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

NVS

Novartis

$87.03

0.03 (0.03%)

CMCSA

Comcast

$42.89

0.39 (0.92%)

GE

General Electric

$16.87

0.7034 (4.35%)

UTX

United Technologies

$135.42

0.2064 (0.15%)

ABT

Abbott

$59.32

-0.2501 (-0.42%)

GD

General Dynamics

$207.58

-0.62 (-0.30%)

ITW

Illinois Tool Works

$172.75

-0.645 (-0.37%)

NSC

Norfolk Southern

$150.90

-0.57 (-0.38%)

BHGE

Baker Hughes

$35.81

0.26 (0.73%)

PGR

Progressive

$57.18

-1.04 (-1.79%)

RCL

Royal Caribbean

$127.33

-1.37 (-1.06%)

SWK

Stanley Black & Decker

$174.31

-0.92 (-0.53%)

ROK

Rockwell Automation

$206.01

2.075 (1.02%)

NTRS

Northern Trust

$107.43

0.94 (0.88%)

GWW

Grainger

$230.43

0.57 (0.25%)

ROL

Rollins

$47.90

0.02 (0.04%)

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  • 24

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  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

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    Jan

  • 24

    Jan

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    Jan

  • 08

    Feb

  • 16

    Feb

  • 02

    Mar

  • 23

    Apr

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    May

TXN

Texas Instruments

$119.44

2.61 (2.23%)

, COF

Capital One

$105.09

-0.4 (-0.38%)

13:59
01/23/18
01/23
13:59
01/23/18
13:59
Earnings
Notable companies reporting after market close »

Notable companies…

TXN

Texas Instruments

$119.44

2.61 (2.23%)

COF

Capital One

$105.09

-0.4 (-0.38%)

UAL

United Continental

$77.39

0.52 (0.68%)

TSS

TSYS

$83.64

-0.11 (-0.13%)

NAVI

Navient

$13.52

-0.08 (-0.59%)

CREE

Cree

$36.69

0.4 (1.10%)

FUL

H.B. Fuller

$55.11

0.22 (0.40%)

03/08/13
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03/06/13
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  • 23

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