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AZN

AstraZeneca

$35.59

0.19 (0.54%)

, MRK

Merck

$58.56

0.96 (1.67%)

12:46
01/12/18
01/12
12:46
01/12/18
12:46

AstraZeneca, Merck say FDA approves Lynparza

AstraZeneca (AZN) and Merck (MRK) announced that the US Food and Drug Administration has approved LYNPARZA, for use in patients with deleterious or suspected deleterious germline BRCA-mutated, human epidermal growth factor receptor 2-negative metastatic breast cancer who have been previously treated with chemotherapy in the neoadjuvant, adjuvant or metastatic setting. Patients with hormone receptor positive breast cancer should have been treated with a prior endocrine therapy or be considered inappropriate for endocrine therapy. Patients are selected for therapy based on an FDA-approved companion diagnostic from Myriad Genetics. Dave Fredrickson, Executive Vice President, Head of the Oncology Business Unit, AstraZeneca, said: "This new approval for LYNPARZA makes it the first and only PARP inhibitor approved in metastatic breast cancer, and the only PARP inhibitor approved beyond ovarian cancer. This is significant for breast cancer patients, as the identification of BRCA status, in addition to hormone receptor and HER2 status, becomes a potentially critical step in the management of their disease."

AZN

AstraZeneca

$35.59

0.19 (0.54%)

MRK

Merck

$58.56

0.96 (1.67%)

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AZN AstraZeneca
$35.59

0.19 (0.54%)

12/05/17
DBAB
12/05/17
NO CHANGE
DBAB
Buy
AstraZeneca positioned to lead in ovarian cancer, says Deutsche Bank
Deutsche Bank analyst Richard Parkes believes recent "strong data" of Tagrisso/Imfinzi mark a turning point for AstraZeneca and the profitability of its lung cancer franchise. The analyst says his survey of 47 U.S. physicians treating patients with ovarian cancer suggests "strong uptake" of the PARP inhibitors class across multiple lines of therapy. Physicians perceive the various approved drugs as comparable on efficacy but with tolerability favoring AstraZeneca's Lynparza, Parkes tells investors in a research note. He believes AstraZeneca will emerge as market leader in a potential greater than $7B class, with "significant upside potential" to consensus forecasts. The analyst reiterates a Buy rating on the shares.
12/29/17
JPMS
12/29/17
UPGRADE
JPMS
Overweight
AstraZeneca upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst James Gordon upgraded AstraZeneca to Overweight and raised his price target for the shares to 55 pounds from 48 pounds. The company's "superior medium-term growth outlook," which is twice the peer average, warrants a 25% sector premium, Gordon tells investors in a research note. He believes downside risk around the Mystic trial failure and "overly high base business expectations" have now lessened with consensus earnings forecasts declining 15%. The analyst expects AstraZeneca to return to sales growth in 2018, even without further immuno-oncology trial success. Astra has 10 Phase III readouts, with fairly low expectations across the board, Gordon argues.
12/29/17
12/29/17
NO CHANGE

On The Fly: Top five analyst actions
Catch up on today's top five analyst actions with this list compiled by The Fly: 1. AstraZeneca (AZN) upgraded to Overweight from Neutral at JPMorgan with analyst James Gordon saying the company's "superior medium-term growth outlook," which is twice the peer average, warrants a 25% sector premium. 2. PriceSmart (PSMT) upgraded to Outperform from Market Perform at IFS Securities. 3. Novo Nordisk (NVO) upgraded to Neutral from Underweight at JPMorgan with analyst Richard Vosser saying he expects "strong" oral semaglutide Phase III newsflow in 2018. 4. Syntel (SYNT) downgraded to Underperform from Market Perform at Wells Fargo with analyst Ed Caso saying he sees the company's "weak" positioning for the ongoing shift in information technology demand from "legacy" low-cost offshore-centric software services to more onshore-necessary "digital" solutions as dragging down its growth and margins. 5. RioCan REIT downgraded to Sector Perform from Outperform at RBC Capital. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
01/02/18
ADAM
01/02/18
NO CHANGE
Target $77
ADAM
Buy
ANI Pharmaceuticals best positioned in emerging generics space, says Canaccord
Canaccord analyst Dewey Steadman said ANI Pharmaceuticals (ANIP) is one of the best positioned names in the emerging generics space. He noted the company has a basket of additional branded tail assets from its AstraZeneca (AZN) acquisitions, additional cash on hand and credit facilities for future transactions, and a solid core business. Steadman reiterated his Buy rating and raised his price target to $77 from $75 on ANI Pharmaceuticals shares.
MRK Merck
$58.56

0.96 (1.67%)

11/16/17
JEFF
11/16/17
NO CHANGE
JEFF
Buy
Jefferies names Roche new top global pick in Pharmaceuticals
Jefferies analyst Jeffrey Holford names Roche (RHHBY) his new "Top Pick Globally" in Pharmaceuticals following the strong share performance of his previous top pick for 2017, AbbVie (ABBV). The analyst believes the company's growth outlook is better than many investors think. Roche is nearing sentiment lows and investors "need to look hard at the replacement power" offered by assets Tecentriq, Ocrevus, Gazyva, ACE910 and Perjeta, Holford tells investors in a research note. Following Roche, the analyst has the highest conviction on Novartis (NVS), Bayer (BAYRY), AbbVie, Johnson & Johnson (JNJ), Zoetis (ZTS) and Eli Lilly (LLY). His least preferred stocks in Pharmaceuticals are Merck (MRK), Novo Nordisk (NVO) and AstraZeneca (AZN).
11/24/17
DBAB
11/24/17
NO CHANGE
Target $59
DBAB
Hold
Deutsche cuts Merck target to $59 on competition from AbbVie, GSK
Deutsche Bank analyst Gregg Gilbert lowered his price target for Merck (MRK) to $59 from $62 citing expectations for more competitive pressure on Zepatier and Zostavax. The stock closed Wednesday up 10c to $54.37. Demand trends for Merck's hepatitis C virus drug Zepatier have continued to decline as AbbVie's (ABBV) Mavyret has gained traction, Gilbert told investors in a research note. The analyst also assumes "significant pressure" on Merck's shingles vaccine Zostavax from the near-term competitive launch of GlaxoSmithKline's (GSK) Shingrix. Gilbert views Merck's risk/reward as fairly balanced and he keeps a Neutral rating on the shares.
11/28/17
BOFA
11/28/17
INITIATION
Target $64
BOFA
Buy
Merck reinstated with a Buy at BofA/Merrill
BofA/Merrill analyst Jason Gerberry reinstated coverage on Merck with a Buy and $64 price target citing attractive valuation, diversified revenue streams, pipeline potential, and a history of returning cash.
12/07/17
PIPR
12/07/17
NO CHANGE
PIPR
Roche lung cancer data underwhelming versus Merck's, says Piper Jaffray
Piper Jaffray analyst Richard Purkiss says that while Roche's (RHHBY) IMpower150 data are strong and suggesting a likelihood that the combination of Tecentriq with Avastin and chemo will be approved in non-small cell lung cancer, the data also appear underwhelming compared to Merck's (MRK) KN-21G trial data. The analyst does expect Tecentriq approval in lung cancer next year and reiterates an Overweight rating on Roche. Whether KN-021G represents the "high water mark" for efficacy can only be answered following full presentation of the remaining pivotal Phase 3 trials in this setting, and until then confusion is likely to remain, Purkiss tells investors in a research note. Merck in premarket trading is up 85c to $55.20 while Roche is down 93c to $30.40.

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TGT

Target

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Omnicom

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Johnson & Johnson

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LLY

Eli Lilly

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Valero

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Emerson

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MU

Micron

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Altice USA

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Micron

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Xilinx

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Xilinx

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ZTE Corp.

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Daimler AG

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FCAU

Fiat Chrysler

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Honda

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Nissan

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F

Ford

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General Motors

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TM

Toyota

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VLKAY

Volkswagen

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Bank of America

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Citi

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Goldman Sachs

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JPM

JPMorgan

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Morgan Stanley

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U.S. Bancorp

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Wells Fargo

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Twitter

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Alcoa

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Century Aluminum

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American Outdoor Brands

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HCLP

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Abiomed

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Wyndham

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Hot Stocks
Abiomed to enter S&P 500 index on May 31 »

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Microsemi

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PRA Health

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GameStop

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Fred's

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Roadrunner

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PRA Health

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Wyndham

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Microsemi

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PG&E

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Farmer Bros.

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NDLS

Noodles & Company

$8.90

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Breaking Syndicate news story on Noodles & Company »

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WIN

Windstream

$1.22

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Noodles & Company

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EPD

Enterprise Products

$27.87

-0.12 (-0.43%)

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INO

Inovio

$4.89

0.06 (1.24%)

16:37
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Breaking Syndicate news story on Inovio »

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RCII

Rent-A-Center

$10.14

0.13 (1.30%)

16:36
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AKER

Akers Biosciences

$0.59

0.0086 (1.48%)

16:34
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Akers Biosciences receives delinquency notice from NASDAQ »

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DHCP

Ditech

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0.37 (5.94%)

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GPS

Gap

$28.15

-4.82 (-14.62%)

, FL

Foot Locker

$55.97

9.585 (20.67%)

16:30
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General news
On The Fly: Top stock stories for Friday »

Stocks on Wall Street…

GPS

Gap

$28.15

-4.82 (-14.62%)

FL

Foot Locker

$55.97

9.585 (20.67%)

HLF

Herbalife Nutrition

$48.76

-5.09 (-9.45%)

IEP

Icahn Enterprises

$69.41

0.22 (0.32%)

FCAU

Fiat Chrysler

$21.82

-0.445 (-2.00%)

DGX

Quest Diagnostics

$105.89

5 (4.96%)

UNH

UnitedHealth

$244.96

2.23 (0.92%)

ROST

Ross Stores

$77.35

-5.6 (-6.75%)

ADSK

Autodesk

$132.80

-5.96 (-4.30%)

AAL

American Airlines

$44.89

1.34 (3.08%)

LUV

Southwest

$52.86

1.65 (3.22%)

DAL

Delta Air Lines

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1.48 (2.72%)

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16:30
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Options
Preliminary option volume of 16.4M today »

Preliminary option volume…

VTL

Vital Therapies

$5.65

-0.475 (-7.76%)

16:26
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05/25
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16:26
Syndicate
Breaking Syndicate news story on Vital Therapies »

Vital Therapies files to…

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