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EXEL

Exelixis

$29.65

-0.73 (-2.40%)

, IPSEY

Ipsen

$31.19

(0.00%)

17:06
01/16/18
01/16
17:06
01/16/18
17:06

Exelixis and Ipsen disclose Phase 3 results of Cabozantinib

Exelixis (EXEL) and Ipsen (IPSEY) announced detailed results of the pivotal phase 3 CELESTIAL trial in patients with previously treated advanced hepatocellular carcinoma, which will be presented in a late-breaking oral session at the 2018 ASCO-GI Symposium being held in San Francisco, January 18-20, 2018. In CELESTIAL, cabozantinib provided a statistically significant and clinically meaningful improvement versus placebo in overall survival, the trial's primary endpoint, at the planned second interim analysis for the population of second- and third-line patients enrolled in this study. Median OS was 10.2 months with cabozantinib versus 8.0 months with placebo. Median progression-free survival was more than doubled, at 5.2 months with cabozantinib and 1.9 months with placebo . Objective response rates per RECIST 1.1 were 4 percent with cabozantinib and 0.4 percent with placebo. Disease control was achieved by 64 percent of the cabozantinib group compared with 33 percent of the placebo group. In a subgroup analysis of patients whose only prior therapy for advanced HCC was sorafenib, median OS was 11.3 months with cabozantinib versus 7.2 months with placebo. Median PFS in the subgroup was 5.5 months with cabozantinib versus 1.9 months with placebo. Adverse events were consistent with the known safety profile of cabozantinib.

EXEL

Exelixis

$29.65

-0.73 (-2.40%)

IPSEY

Ipsen

$31.19

(0.00%)

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EXEL Exelixis
$29.65

-0.73 (-2.40%)

10/16/17
RHCO
10/16/17
NO CHANGE
Target $35
RHCO
Buy
Cabo result better positions Exelixis as acquisition target, says SunTrust
SunTrust analyst Peter Lawson raised his price target on Exelixis (EXEL) to $35 from $33 and maintained his Buy rating, saying the latest CELESTIAL trial cabozantinib positions the treatment well against its main competitor - Bayer's (BAYRY) Regorafenib. Lawson adds that the trial result validates the expansion of cabozantinib beyond kidney cancer and better positions Exelixis as a potentially attractive M&A target.
10/16/17
PIPR
10/16/17
NO CHANGE
Target $33
PIPR
Overweight
Exelixis price target raised to $33 from $29 at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff raised his price target for Exelixis shares to $33 after the company said the Phase III Celestial trial of Cabometyx met the primary endpoint. The analyst is confident front-line approval next year will grow renal cell carcinoma product sales to $392M in 2018. He reiterates an Overweight rating on Exelixis.
10/17/17
NEED
10/17/17
NO CHANGE
Target $33
NEED
Buy
Exelixis price target raised to $33 from $30 at Needham
Needham analyst Chad Messer raised his price target on Exelixis (EXEL) to $33, noting the latest trial data for advanced renal cell carcinoma treatment, Cabozantinib, positions it for near and long term growth. Messer says the results may be sufficient to allay competitive concerns from the recently approved Bayer (BAYRY) Stivarga, as cabozantinib offers a potentially more attractive efficacy profile.
01/04/18
PIPR
01/04/18
NO CHANGE
Target $37
PIPR
Overweight
Piper ups Exelixis target to $37, names a top pick for 2018
Piper Jaffray analyst Edward Tenthoff names Exelixis a top pick for 2018 and raised his price target for the shares to $37 from $33. The analyst expects Cabometyx growth from driven label expansion and is positive into the Phase III Cotexo data in the first half of 2018.
IPSEY Ipsen
$31.19

(0.00%)

09/19/17
SOCG
09/19/17
UPGRADE
SOCG
Buy
Ipsen upgraded to Buy from Hold at Societe Generale
Societe Generale analyst Delphine Le Louet upgraded Ipsen to Buy with a price target of EUR 126.

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INTU

Intuit

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INTU

Intuit

$216.47

2.06 (0.96%)

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CSX

CSX

$64.42

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INTU

Intuit

$216.47

2.06 (0.96%)

08:35
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TWTR

Twitter

$44.70

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Downgrade
Twitter, Amazon.com, Facebook, Apple, Alphabet Class A, Alphabet, eBay rating change  »

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TWTR

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$44.70

0.45 (1.02%)

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$1,844.00

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eBay

$37.82

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LTXB

LegacyTexas Financial

$39.01

-0.04 (-0.10%)

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FHN

First Horizon

$17.18

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SYF

Synchrony

$32.82

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INTU

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ERIC

Ericsson

$7.64

-0.015 (-0.20%)

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TEUM

Pareteum

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PYPL

PayPal

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BWP

Boardwalk Pipeline

$0.00

(0.00%)

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Options
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HCSG

Healthcare Services

$42.38

-0.3297 (-0.77%)

, GEN

Genesis Healthcare

$1.45

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FPI

Farmland Partners

$6.28

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08:26
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Upgrade
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