Compugen presents new data demonstrating features of the PVRIG pathway
Compugen announced new preclinical data demonstrating distinctive features of the PVRIG pathway and the potential of COM701, a first-in-class therapeutic antibody candidate targeting PVRIG, for treating multiple solid tumors. The data, presented at the Keystone Symposia Conference, A3: T Cell Dysfunction, Cancer and Infection, being held January 16-20, 2018, at the Beaver Run Resort, Breckenridge, CO, provide indication for a dominant role of the PVRIG/TIGIT axis in cancer evasion of immune response in multiple cancers. The data also support the Company's biomarker strategy and clinical development program for COM701, as a monotherapy and in combination treatment with COM902, Compugen's therapeutic antibody candidate targeting TIGIT, and with PD-1 blockers. The poster titled "PVRIG Expression is Associated with T Cell Exhaustion and Synergizes with TIGIT to Inhibit Anti-Tumor Responses" (Poster no. 2028) includes data showing higher expression of PVRL2, the ligand for PVRIG, compared to expression of PVR, the ligand for TIGIT, in tumor types that include breast, endometrial, and ovarian cancers. These results suggest that PVRIG may be the dominant checkpoint in diverse patient populations with tumors that express elevated PVRL2, many of which are not responsive to PD-1 inhibitors, and which may have an increased likelihood of responding to COM701 as a monotherapy treatment.