ChemoCentryx reports 'positive' survival results from CCX872 trial
ChemoCentryx announced positive overall survival results from an ongoing Phase Ib clinical trial of the company's second CCR2 inhibitor - CCX872 - in the treatment of locally advanced/metastatic pancreatic cancer. The study demonstrated OS of 29% at 18 months with CCX872 and FOLFIRINOX combination therapy in all patients treated. The OS rate of 29% in the present study of CCX872 compares favorably with previously published OS rates of 18.6% using FOLFIRINOX alone to treat pancreatic cancer patients with metastatic disease. The findings will be presented during the ASCO-SITC Clinical Immuno-Oncology Symposium, being held January 25-27, 2018 in San Francisco, CA. "The positive findings from our pancreatic cancer trial demonstrate that improved patient survival could result from selectively inhibiting CCR2 with CCX872, thereby blocking the immune-suppressing cells that CCR2 maintains in the tumor environment. This is a new approach aimed at liberating the body's own potential for a powerful anti-tumor immune response," said Thomas J. Schall, Ph.D., President and Chief Executive Officer of ChemoCentryx. "These data support CCX872 as a very promising, novel immunotherapeutic approach to treating this deadly form of cancer. Building on these highly encouraging results, we look forward to the opportunity to advance CCX872 in combination with other therapies."