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BMRN

BioMarin

$86.93

-0.48 (-0.55%)

12:16
02/07/18
02/07
12:16
02/07/18
12:16

BioMarin 'encouraged' by interim data from BMN 250 Phase 1/2 trial

BioMarin Pharmaceutical announced that it presented interim data from a Phase 1/2 trial for BMN 250, an investigational enzyme replacement therapy using a novel fusion of recombinant human alpha-N-acetylglucosaminidase with a peptide derived from insulin-like growth factor 2, for the treatment of Sanfilippo B syndrome or mucopolysaccharidosis IIIB at WORLDSymposium 2018. Discovered by BioMarin, BMN 250 is being studied in a multicenter, international clinical trial evaluating safety and tolerability, as well as cognitive function of patients with Sanfilippo B receiving BMN 250. Designed to restore functional NAGLU activity in the brain, BMN 250 is administered via intracerebroventricular infusion. "These studies are generating a robust data set to determine the safety and efficacy of BMN 250 in Sanfilippo B," said Hank Fuchs, M.D., President, Worldwide Research and Development at BioMarin. "While it is still very early, we are encouraged that the interim data is showing normalization of an important biomarker and liver size, as well as suggesting a stabilization in cognitive decline. We appreciate the support of the Sanfilippo community to study this experimental treatment, and we remain committed to contributing to the body of scientific knowledge of this devastating disease."

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BMRN BioMarin
$86.93

-0.48 (-0.55%)

12/15/17
12/15/17
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Foot Locker (FL) upgraded to Buy from Hold by Canaccord analyst Camilo Lyon, who believes the company is approaching the end of the inventory clearance cycle it has been in for the past three quarters and that the company's relationship with Nike (NKE) is "strong and symbiotic." 2. Stifel analyst Jim Duffy upgraded Under Armour (UAA) to Buy from Hold, saying he expects the company's business to be in a much better position entering 2019 and for the stock to begin to anticipate improvements before it shows in reported results. 3. Argus analyst John Staszak upgraded Skechers (SKX) to Buy from Hold with a price target of $44, citing signs that a recovery in the company's domestic wholesale business has commenced. 4. Goldman analyst Robert Jones upgraded AmerisourceBergen (ABC) to Buy from Neutral, telling investors he believes an EBIT inflection in FY18 is coming. 5. Goldman Sachs analyst Jami Rubin added BioMarin (BMRN) and Alnylam (ALNY) to the firm's Conviction Buy List, upgrading them both from Buy. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
12/18/17
SBSH
12/18/17
NO CHANGE
SBSH
Citi downgrades stance on large-cap Biotechnology to Neutral
Citi analyst Robyn Karnauskas downgraded her view on the large-cap Biotechnology sector to Neutral heading into 2018. The negative sentiment on the space may not change in the near term as valuations are not cheap and there are few catalysts in 2018, Karnauskas tells investors in a research note. Valuations in the group do not appear cheap when you look at the growth profile of large-cap biotech versus the broader market, the analyst contends. She believes the "only way out for the sector is innovation," and prefers to move to the sidelines "until we see something there." Where Karnauskas does see upside in 2018 is in shares of Alexion (ALXN), BioMarin (BMRN), Vertex (VRTX) and Tesaro (TSRO).
12/18/17
MSCO
12/18/17
NO CHANGE
MSCO
Morgan Stanley sees opportunities in biotech amid 'limited' investor conviction
With clinical catalysts in large-cap Biotechnology limited to only five key Phase III readouts - three of which are from Alexion (ALXN) - investors are describing their 2018 picks in the space as the "least worst" of the group, according to Morgan Stanley analyst Matthew Harrison. However, he believes this lack of conviction creates real opportunity for outsized moves in 2018, with Amgen (AMGN) identified by Harrison as the biggest potential beneficiary of M&A given "its likely newfound access" to about $39B in offshore cash. Other biotech names the analyst highlights on the up side include Biogen (BIIB), BioMarin (BMRN), Biohaven (BHVN) and Sarepta (SRPT). Meanwhile, Harrison highlights his concerns about potential downside for BioVerativ (BIVV) and Innoviva (INVA), on both of which he keeps Underweight ratings.
01/18/18
FBCO
01/18/18
INITIATION
Target $113
FBCO
Outperform
BioMarin assumed with an Outperform at Credit Suisse
Credit Suisse analyst Martin Auster assumed coverage of BioMarin with an Outperform rating and $113 price target, pointing to 2018 and 2019 catalysts that include the May 2018 PDUFA for pegvaliase, the emergence of its valrox gene therapy for hemophilia and progress with vosoritide.

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