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TTPH

Tetraphase

$5.43

-0.03 (-0.55%)

16:08
02/13/18
02/13
16:08
02/13/18
16:08

Tetraphase says IGNITE3 trial did not achieve its co-primary endpoints

Tetraphase Pharmaceuticalsannounced that its IGNITE3 clinical trial evaluating the efficacy and safety of once-daily intravenouseravacycline compared to ertapenem for the treatment of patients with complicated urinary tract infections did not achieve statistical non-inferiority of eravacycline to ertapenem. The study failed to meet the co-primary efficacy endpoints of responder rate in the microbiological intent-to-treat (micropopulation at the end-of-IV treatment visit and at the test-of-cure (TOC) visit, which were evaluated using a 10% non-inferiority margin. Eravacycline was well tolerated in IGNITE3, with a safety profile consistent with prior studies. "We are surprised and obviously very disappointed that the IGNITE3 trial did not achieve its co-primary endpoints and are fully analyzing the data to understand this outcome," said Guy Macdonald, President and CEO of Tetraphase. "Independent of this outcome, we continue to move forward with our registration strategy for eravacycline in complicated intra-abdominal infections. We currently have an NDA under review with the FDA as well as an MAA under review by the EMA in Europe, which are based on the positive outcomes demonstrating high cure rates and favorable tolerability in the IGNITE1 and IGNITE4 phase 3 clinical trials of IV eravacycline in cIAI. We are actively preparing for the commercialization of eravacycline as a treatment in cIAI in both the U.S and in Europe, assuming regulatory approvals."

TTPH Tetraphase
$5.43

-0.03 (-0.55%)

11/06/17
HCWC
11/06/17
NO CHANGE
Target $17
HCWC
Buy
Tetraphase price target raised to $17 from $15 at H.C. Wainwright
H.C. Wainwright analyst Ed Arce raised his price target for Tetraphase to $17 saying the six corporate milestones laid out in the Q3 earnings release "highlight several potential value-creating stock catalysts in 2018." The analyst believes the company is well positioned to achieve the milestones. He keeps a Buy rating on the shares.
02/06/18
HCWC
02/06/18
NO CHANGE
Target $17
HCWC
Buy
Tetraphase risk/reward 'highly favorable' into data, says H.C. Wainwright
H.C. Wainwright analyst Ed Arce says the imminent data readout of the Phase 3 Ignite3 study is a "major potential catalyst" for the shares of Tetraphase Pharmaceuticals. The analyst believes the trial "will be a solid, clean win." He views the Ignite3 readout as a "highly favorable" risk/reward equity position, with a risk-adjusted expected value of the shares of about $9.50 post-data. The analyst affirms a Buy rating on Tetraphase with a $17 price target.
02/12/18
RILY
02/12/18
INITIATION
Target $11
RILY
Buy
Tetraphase initiated with a Buy at B. Riley FBR
B. Riley FBR analyst Madhu Kumar started Tetraphase Pharmaceuticals with a Buy rating and $11 price target. The analyst sees "broad" antibiotic potential for the company and believes its Phase III readout in Q1 is de-risked.
02/12/18
02/12/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. First Solar (FSLR) initiated with an Underperform at Credit Suisse. The firm also started SunPower (SPWR) with a Neutral and Sunrun (RUN) with an Outperform. 2. Genocea (GNCA) initiated with an Outperform at Baird. 3. Tetraphase (TTPH) initiated with a Buy at B. Riley FBR. 4. Aspen Group (ASPU) initiated with a Buy at Craig-Hallum. 5. Vermilion Energy (VET) initiated with an Overweight at JPMorgan. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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SNHY

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LUV

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CREE

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DB

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MNLO

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