Breaking News Instant updates and real-time market news.

BIIB

Biogen

$296.08

-20.91 (-6.60%)

, MRK

Merck

$54.98

0.08 (0.15%)

11:13
02/15/18
02/15
11:13
02/15/18
11:13

Analysts caution against overreacting to Biogen's Alzheimer's trial change

At an industry conference yesterday, Biogen (BIIB) said the company has decided to add 510 patients to the Phase 3 aducanumab trials after seeing more "variability" than expected in a sample size re-estimation, sending its shares into negative territory. William Blair analyst Matt Phipps, however, argued that an enrollment increase is not unusual, with his peer at Piper Jaffray recommending investors buy Biogen shares amid the weakness. INCREASE 'PRUDENT, NOT UNUSUAL': Commenting on Biogen's announcement, William Blair's Phipps told investors that the increase in variability in and of itself does not preclude trial success. Further, the analyst said he believes increasing enrollment to ensure appropriate powering and confidence interval error margin is "prudent and not unusual." The trial is sufficiently powered to detect a benefit significantly below what was observed in the Phase Ib trial, he contended. Phipps also pointed out that he sees "very limited" downside at current price levels if aducanumab were to fail, and added that success of Biogen's growing earlier stage pipeline has the potential to provide additional upside. The analyst reiterated an Outperform rating on the stock. Also keeping an Overweight rating on Biogen's shares, Piper Jaffray analyst Christopher Raymond recommended using the selloff in the stock as a buying opportunity. While it is "a bit unnerving," particularly on the heels of another Phase 3 Alzheimer's failure for Merck's (MRK) verubecestat, the study remains blinded and variability on the primary endpoint can stem from a host of reasons, not all of them bad, Raymond told investors in a research note of his own. The analyst pointed out that variability in CDR-SB could be caused by a number of factors, such as a heterogeneous patient population, which would not necessarily doom it to failure either, or potentially a larger effect size, among other possibilities. Overall, Raymond does not think the news says much about the chances for an interim analysis or about aducanumab's efficacy profile. ALZHEIMER'S UNCERTAINTY RETURNS: Not as bullish after Biogen provided some updates to its Phase 3 Alzheimer's study, Jefferies analyst Michael Yee told investors that the changes do not necessarily dramatically change the probability of success, but do change Wall Street's "sense of confidence." The analyst said he believes the market will "swing back to uncertainty" on the Alzheimer's pendulum, and thinks Biogen needs to acquire de-risked "neuro/orphan companies" to "change the narrative" from being a binary Alzheimer's company. He reiterated a Hold rating and $375 price target on the shares. PRICE ACTION: In morning trading, shares of Biogen were fractionally down to $295.20 after dropping over 5% yesterday.

BIIB

Biogen

$296.08

-20.91 (-6.60%)

MRK

Merck

$54.98

0.08 (0.15%)

  • 15

    Feb

  • 08

    Mar

  • 25

    Mar

  • 03

    Apr

  • 04

    Apr

  • 23

    Apr

  • 30

    May

  • 23

    Oct

BIIB Biogen
$296.08

-20.91 (-6.60%)

02/15/18
PIPR
02/15/18
NO CHANGE
Target $407
PIPR
Overweight
Biogen selloff yesterday a buying opportunity, says Piper Jaffray
Piper Jaffray analyst Christopher Raymond recommends using the selloff yesterday in shares of Biogen (BIIB) as a buying opportunity. The stock pulled back after management disclosed at a conference plans to up-size the Phase 3 aducanumab program by 510 patients total. While "this is a bit unnerving," particularly on the heels of another Phase 3 Alzheimer's failure for Merck's (MRK) verubecestat, the study remains blinded and variability on the primary endpoint can stem from a host of reasons, not all of them bad, Raymond tells investors in a research note titled "Aducanumab P3 Upsizing Doesn't Tell Us Much." The analyst does not think yesterday's news says much about the chances for an interim analysis or about aducanumab's efficacy profile. He keeps an Overweight rating on Biogen with a $407 price target.
02/15/18
ADAM
02/15/18
NO CHANGE
Target $350
ADAM
Hold
Biogen trial change does not alter efficacy assumptions, says Canaccord
Canaccord analyst Sumant Kulkarni noted Biogen announced an upsizing to its Alzheimer drug trial due to greater variability on the primary endpoint. The analyst said this was based on a pre-specified plan and does not change the efficacy assumptions of the drug. As a result he expects the shares to recover some of their losses. Kulkarni maintained his Hold rating and $350 price target on Biogen shares.
02/15/18
WBLR
02/15/18
NO CHANGE
WBLR
Outperform
Biogen enrollment increase is not unusual, says William Blair
William Blair analyst Matt Phipps believes increasing enrollment of Biogen's Phase III trials of aducanumab in prodromal Alzheimer's disease to ensure appropriate powering and confidence interval error margin, which caused yesterday's share selloff, is "prudent and not unusual." Based on his analysis, the trial is sufficiently powered to detect a benefit significantly below what was observed in the Phase Ib trial. The increase in variability in and of itself does not preclude trial success, Phipps tells investors in a research note. He sees "very limited" downside at current price levels if aducanumab were to fail, and adds that success of Biogen's growing earlier stage pipeline has the potential to provide additional upside. The analyst sees upside potential of over 50%, to $500 per share, if Phase III trials of aducanumab are successful, and a base support level slightly below $300 per share if the trials fail. Phipps keeps an Outperform rating on Biogen.
02/15/18
MSCO
02/15/18
NO CHANGE
Target $385
MSCO
Overweight
Morgan Stanley says Biogen Alzheimer trial change could be positive or negative
Morgan Stanley analyst Matthew Harrison noted that Biogen management indicated during an industry conference presentation that the enrollment for the Phase 3 aducanumab trials in Alzheimer's was being increased by 510 patients. Investors clearly took this as bad news, but "we just don't have enough information to know if the reason driving the change is bad or good," Harrison tells investors. The higher variability could be driven by a larger than expected treatment effect and "it is completely possible...aducanumab is actually doing better than expected," he added. Stating that the news doesn't fundamentally change his positive view on Biogen, Harrison maintains an Overweight rating on the shares.
MRK Merck
$54.98

0.08 (0.15%)

01/17/18
BMOC
01/17/18
NO CHANGE
Target $72
BMOC
Outperform
Merck price target raised to $72 from $68 at BMO Capital
BMO Capital analyst Alex Arfaei raised his price target on Merck to $72 from $68, keeping his Outperform rating following a 6% move higher in the stock price yesterday. The analyst says he remains bullish based on a "meaningful upside for Keytruda" and better performance from supporting drug franchises such as Gardasil. Arfaei warns however that while Keytruda has solidified its lead in non-small cell lung cancer market, it remains the company's only major growth driver while immuno oncology becomes increasingly more competitive.
02/14/18
BMOC
02/14/18
NO CHANGE
Target $65
BMOC
Outperform
Merck price target lowered to $65 from $70 at BMO Capital
BMO Capital analyst Alex Arfaei lowered his price target on Merck to $65 after the company discontinued its APECS study. The analyst sees this as "another setback that increases Merck's dependence on Keytruda" and contends that the company needs other meaningful drivers. Arfaei keeps his Outperform rating based on his confidence in Keytruda growth and Merck's Immuno-oncology execution.
02/15/18
02/15/18
UPGRADE
Target $78

Overweight
Bristol-Myers upgraded on immuno-oncology growth prospects at Morgan Stanley
As previously reported, Morgan Stanley analyst David Risinger upgraded Bristol-Myers (BMY) to Overweight from Equal Weight as he has become more optimistic on the immuno-oncology Opdivo + Yervoy combo in first-line lung cancer, which he notes is the largest cancer market. After the analyst reviewed combo toxicity in select combo studies with similar dosing as Bristol's CM-227 and compared cross trial against Merck's (MRK) Keynote-021G trial that tested Keytruda + chemo, he concluded that discontinuation rates due to side effects appear roughly comparable and now thinks Opdivo + Yervoy toxicity in lung cancer is likely to be acceptable. Risinger raised his price target on Bristol-Myers shares to $78 from $63.

TODAY'S FREE FLY STORIES

LOGI

Logitech

$44.24

0.25 (0.57%)

16:56
06/22/18
06/22
16:56
06/22/18
16:56
Initiation
Logitech initiated  »

Logitech initiated with a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

PAGS

PagSeguro Digital

$30.35

0.925 (3.14%)

16:51
06/22/18
06/22
16:51
06/22/18
16:51
Hot Stocks
Breaking Hot Stocks news story on PagSeguro Digital »

Point72 Asset Management…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Jun

APLS

Apellis

$21.75

-0.2 (-0.91%)

16:50
06/22/18
06/22
16:50
06/22/18
16:50
Conference/Events
Apellis to host research and development day »

Research and Development…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$274.75

0.47 (0.17%)

16:50
06/22/18
06/22
16:50
06/22/18
16:50
Periodicals
SEC investigates whether companies rounded up earnings, WSJ reports »

The U.S. Securites and…

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$274.75

0.47 (0.17%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

THRM

Gentherm

$38.20

-0.75 (-1.93%)

16:45
06/22/18
06/22
16:45
06/22/18
16:45
Conference/Events
Gentherm to hold a strategic update »

Strategic Update for the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MGTX

MeiraGTx

$11.86

-0.97 (-7.56%)

16:43
06/22/18
06/22
16:43
06/22/18
16:43
Hot Stocks
Breaking Hot Stocks news story on MeiraGTx »

Perceptive Advisors…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MDT

Medtronic

$86.80

0.51 (0.59%)

16:39
06/22/18
06/22
16:39
06/22/18
16:39
Conference/Events
Medtronic to hold an analyst and investor briefing »

In conjunction with the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Jun

  • 25

    Jun

  • 26

    Jun

  • 12

    Jul

FOXA

21st Century Fox

$48.59

0.25 (0.52%)

, FOX

21st Century Fox

$48.28

0.31 (0.65%)

16:35
06/22/18
06/22
16:35
06/22/18
16:35
Hot Stocks
21st Century Fox extends CFO John Nallen's employment contract to 2021 »

On June 22, 21st Century…

FOXA

21st Century Fox

$48.59

0.25 (0.52%)

FOX

21st Century Fox

$48.28

0.31 (0.65%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

FENC

Fennec

$10.97

0.5 (4.78%)

16:34
06/22/18
06/22
16:34
06/22/18
16:34
Hot Stocks
Breaking Hot Stocks news story on Fennec »

Opaleye Management…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SBBP

Strongbridge Biopharma

$6.20

-0.15 (-2.36%)

16:33
06/22/18
06/22
16:33
06/22/18
16:33
Hot Stocks
Breaking Hot Stocks news story on Strongbridge Biopharma »

Opaleye Management…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 26

    Jun

16:30
06/22/18
06/22
16:30
06/22/18
16:30
Options
Preliminary option volume of 16.8M today »

Preliminary option volume…

COOL

PolarityTE

$38.91

-0.09 (-0.23%)

16:28
06/22/18
06/22
16:28
06/22/18
16:28
Conference/Events
PolarityTE to hold a meeting »

Management hosts a Key…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 25

    Jun

  • 26

    Jun

NOG

Northern Oil and Gas

$2.74

0.09 (3.40%)

16:25
06/22/18
06/22
16:25
06/22/18
16:25
Syndicate
Breaking Syndicate news story on Northern Oil and Gas »

Northern Oil and Gas…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

NOG

Northern Oil and Gas

$2.74

0.09 (3.40%)

16:23
06/22/18
06/22
16:23
06/22/18
16:23
Syndicate
Breaking Syndicate news story on Northern Oil and Gas »

Northern Oil and Gas…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SNH

Senior Housing

$18.19

0.29 (1.62%)

16:21
06/22/18
06/22
16:21
06/22/18
16:21
Syndicate
Breaking Syndicate news story on Senior Housing »

Senior Housing files…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

AAWW

Atlas Air

$73.45

-0.5 (-0.68%)

16:21
06/22/18
06/22
16:21
06/22/18
16:21
Conference/Events
Atlas Air to host analyst day »

Analyst meeting to be…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 11

    Sep

  • 12

    Sep

SPY

SPDR S&P 500 ETF Trust

$274.75

0.47 (0.17%)

, USO

United States Oil Fund

$14.02

0.71 (5.33%)

16:20
06/22/18
06/22
16:20
06/22/18
16:20
General news
Weekly CFTC Commitment of Traders highlights »

S&P500 net long 2.9K…

SPY

SPDR S&P 500 ETF Trust

$274.75

0.47 (0.17%)

USO

United States Oil Fund

$14.02

0.71 (5.33%)

GLD

SPDR Gold Trust

$120.33

0.27 (0.22%)

FXE

Euro Currency Trust

$111.91

0.42 (0.38%)

FXC

CurrencyShares Canadian Dollar Trust

$74.31

0.15 (0.20%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

VIX

Volatility Index S&P 500 Options

$0.00

(0.00%)

16:20
06/22/18
06/22
16:20
06/22/18
16:20
Options
Closing CBOE SPX and VIX Index summary for June 22nd »

The CBOE Volatility Index…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

DFS

Discover

$73.38

0.36 (0.49%)

16:19
06/22/18
06/22
16:19
06/22/18
16:19
Syndicate
Breaking Syndicate news story on Discover »

Discover files automatic…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SRNE

Sorrento Therapeutics

$6.55

0.4 (6.50%)

16:18
06/22/18
06/22
16:18
06/22/18
16:18
Hot Stocks
Breaking Hot Stocks news story on Sorrento Therapeutics »

China In Shine Investment…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

NFLX

Netflix

$411.09

-4.39 (-1.06%)

16:18
06/22/18
06/22
16:18
06/22/18
16:18
Hot Stocks
Netflix chief communications officer Friedland to leave company »

Netflix chief…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 16

    Jul

$NSD

NASDAQ Market Internals

$0.00

(0.00%)

16:17
06/22/18
06/22
16:17
06/22/18
16:17
Technical Analysis
NASDAQ market internals summary »

Volume was above average…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

DIS

Disney

$106.37

0.48 (0.45%)

, FOX

21st Century Fox

$48.28

0.31 (0.65%)

16:16
06/22/18
06/22
16:16
06/22/18
16:16
General news
On The Fly: Top stock stories for Friday »

Stocks opened higher but…

DIS

Disney

$106.37

0.48 (0.45%)

FOX

21st Century Fox

$48.28

0.31 (0.65%)

FOXA

21st Century Fox

$48.59

0.25 (0.52%)

CMCSA

Comcast

$33.82

1.02 (3.11%)

CMCSK

Comcast

$0.00

(0.00%)

CIT

CIT Group

$51.38

0.51 (1.00%)

CMA

Comerica

$95.38

-0.62 (-0.65%)

ZION

Zions Bancorp

$55.48

-1.04 (-1.84%)

GS

Goldman Sachs

$225.90

-1.13 (-0.50%)

MS

Morgan Stanley

$48.84

-0.94 (-1.89%)

RHT

Red Hat

$142.23

-23.39 (-14.12%)

AMZN

Amazon.com

$1,715.07

-15.13 (-0.87%)

WSC

Williams Scotsman

$15.25

3.15 (26.03%)

KMX

CarMax

$80.20

9.15 (12.88%)

CDNA

CareDx

$13.00

-1.6 (-10.96%)

NTR

Nutrien

$53.71

0.965 (1.83%)

BB

BlackBerry

$10.68

-1.015 (-8.68%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 22

    Jun

  • 22

    Jun

  • 22

    Jun

  • 22

    Jun

  • 25

    Jun

  • 17

    Jul

XSPA

XpresSpa

$0.41

-0.02 (-4.65%)

16:16
06/22/18
06/22
16:16
06/22/18
16:16
Hot Stocks
XpresSpa CFO Anastasia Nyrkovskaya resigns to pursue other opportunities »

XpresSpa Group announced…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

NOG

Northern Oil and Gas

$2.74

0.09 (3.40%)

16:16
06/22/18
06/22
16:16
06/22/18
16:16
Syndicate
Breaking Syndicate news story on Northern Oil and Gas »

Northern Oil and Gas…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.