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KDMN

Kadmon

$3.60

-0.16 (-4.26%)

18:49
02/22/18
02/22
18:49
02/22/18
18:49

Kadmon updates 'positive' results from Phase 2 study of KD025 in cGVHD

Kadmon announced updated "positive" results from an ongoing Phase 2 clinical trial evaluating KD025, its Rho-associated coiled-coil kinase 2 inhibitor, in patients with chronic graft-versus-host disease. The results are being presented in an oral presentation at the BMT Tandem Meetings in Salt Lake City. Updated data from Cohort 2 of the trial showed an Overall Response Rate of 69%. Responses in Cohort 1 remained the same, showing an ORR of 65%. Responses were rapid, with approximately 70% of patients across Cohorts 1 and 2 achieving responses after 8 weeks of treatment. Responses were observed across all affected organs. 64% of patients were able to reduce steroid dose, and four patients completely discontinued steroid use. KD025 was well tolerated, with no drug-related serious adverse events in either cohort. Kadmon expects to enroll an expansion cohort of approximately 40 patients after the optimal dose has been determined. In October 2017, KD025 received orphan drug designation from the FDA for cGVHD.

KDMN Kadmon
$3.60

-0.16 (-4.26%)

10/09/17
WBBS
10/09/17
DOWNGRADE
WBBS
Sell
Kadmon downgraded to Sell from Hold at WBB Securities
12/21/17
JEFF
12/21/17
NO CHANGE
Target $9
JEFF
Buy
Kadmon Q1 data could bring 'significant' upside, says Jefferies
Jefferies analyst Biren Amin believes Kadmon's Phase II data for KD025 in chronic graft-versus-host disease, expected in Q1 of 2018, represent "significant" upside with little downside risk. KD025 has shown "encouraging activity" in a difficult to treat population, Amin tells investors in a research note. He assumes U.S. market entry of KD025 for treatment of chronic graft-versus-host disease in 2020 and estimates U.S. peak sales of 333.1M. The analyst has a Buy rating on Kadmon shares with a $9 price target.
02/13/18
JEFF
02/13/18
NO CHANGE
Target $16
JEFF
Buy
Kadmon price target raised to $16 from $9 at Jefferies
Jefferies analyst Biren Amin raised his price target for Kadmon Holdings to $16 after the company announced positive data on its Phase II trial of KD025 in idiopathic pulmonary fibrosis. The absolute improvement of 127 mL between arms surpasses the bar of 45-85 mL seen with existing therapies and the shares should react positively, Amin tells investors in a research note. He keeps a Buy rating on Kadmon shares.
02/13/18
PIPR
02/13/18
NO CHANGE
Target $9
PIPR
Overweight
Kadmon price target raised to $9 after data on KD025 at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff noted that Kadmon announced "positive" topline Phase 2 data on KD025 in 29 evaluable idiopathic pulmonary fibrosis, or IPF, patients. Upon adding value for KD025 in IPF, the analyst increased his price target on Kadmon shares to $9 from $7 and reiterated his Overweight rating on the stock.

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LOW

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VIX

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

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