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NTLA

Intellia Therapeutics

$29.01

2.89 (11.06%)

09:30
02/27/18
02/27
09:30
02/27/18
09:30

Intellia announces preclinical data showing effective CRISPR/Cas9 genome editing

Intellia Therapeutics announced that Cell Reports will publish at noon ET today its manuscript, "A single administration of CRISPR/Cas9 lipid nanoparticles achieves robust and persistent in vivo genome editing." The lipid nanoparticle delivery of Cas9 mRNA and sgRNA resulted in 97% reduction in mouse transthyretin protein levels in the liver, and the reduction was sustained for at least 12 months. The publication also documents that CRISPR/Cas9 components were undetectable in mice within three days after administration of Intellia's LNP delivery system. Researchers further demonstrated that Intellia's LNP technology is a similarly robust and effective delivery method for CRISPR/Cas9-mediated knockdown in rats, a higher rodent species.

  • 27

    Feb

NTLA Intellia Therapeutics
$29.01

2.89 (11.06%)

10/31/17
LEER
10/31/17
NO CHANGE
Target $37
LEER
Outperform
Intellia Therapeutics price target raised to $37 from $29 at Leerink
Leerink analyst Joseph Schwartz said Intellia Therapeutics' (NTLA) demonstration of gene editing across multiple animal models brings the company one-step closer to an IND filing. He also believes investors are pricing in an M&A premium following Gilead's (GILD) acquisition of Kite and the approvals of Novartis' (NVS) Kymriah and Gilead's Yescarta. Noting that his valuation "now incorporates a very small fraction" of the Kite acquisition value, he raised his price target on Intellia to $37 from $29 and keeps an Outperform rating on the shares.
10/31/17
JEFF
10/31/17
NO CHANGE
Target $42
JEFF
Buy
Intellia Therapeutics price target raised to $42 from $36 at Jefferies
01/08/18
LEER
01/08/18
NO CHANGE
LEER
Outperform
Intellia Therapeutics selloff on bioRxiv article overdone, says Leerink
Leerink analyst Joseph Schwartz attributes today's selloff in shares of Intellia Therapeutics to concerns raised about the genome editing approach using CRISPR/Cas9 in a paper published by bioRxiv. However, he points out that the articles on that site are not peer-reviewed and he questions the quality of the data. The analyst, who also contends the humoral response issue raised in the repot is unlikely to be material for Intellia, believes today's selloff is overdone and reiterates an Outperform rating on Intellia shares, which are down about 15% in early afternoon trading.
01/09/18
JEFF
01/09/18
NO CHANGE
Target $42
JEFF
Buy
Intellia selloff yesterday a buying opportunity, says Jefferies
Jefferies analyst Maury Raycroft views yesterday's selloff in shares of Intellia Therapeutics as a buying opportunity. The analyst calls the pullback "excessive" based on his analysis of Friday's publication related to CRISPR/Cas9 that raised safety/efficacy questions pertaining to the genome-editing technology. The analyst views the data in the publication as early and limited. He keeps a Buy rating on Intellia with a $42 price target.

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