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SBBP

Strongbridge Biopharma

$8.00

0.2 (2.56%)

14:50
03/18/18
03/18
14:50
03/18/18
14:50

Strongbridge Biopharma presents new data from in vitro study of levoketoconazole

Strongbridge Biopharma announced that results from an in vitro study of levoketoconazole, the active ingredient in RECORLEV, were presented at ENDO 2018, the Annual Meeting of the Endocrine Society, taking place in Chicago, Illinois from March 17 - 20, 2018. The study aimed to characterize the potency and mechanism of 2S,4R-ketoconazole - levoketoconazole, the active ingredient of RECORLEV - inhibition of human steroidogenic enzymes in intact cells in vitro. Levoketoconazole was significantly more potent than the 2R,4S-isomer and approximately twice as potent as racemic ketoconazole for CYPs 11A1, 11B1 and 17A1; the potency differences were less marked for CYP 11B2. Ketoconazole or its enantiomers did not inhibit CYPs 19A1 or 21A2 at up to 1000 nanomolar concentration. The degree of potency differences suggests that levoketoconazole accounts for essentially all of the activity of racemic ketoconazole to inhibit cortisol biosynthesis in humans. Spectral binding constants were about three to five times higher than the IC50 for CYPs 17A1 and 11B1 in intact cells, suggesting that, for these enzymes, a second mode of inhibition not involving the canonical binding pockets of these steroidogenic enzymes accounts for a significant portion of the much greater inhibition potency of levoketoconazole as compared with its mirror-opposite isomer 2R,4S-ketoconazole. RECORLEV, or levoketoconazole, is an investigational cortisol synthesis inhibitor being evaluated in LOGICS and SONICS, two Phase 3 clinical trials for endogenous Cushing's syndrome. The safety and efficacy of RECORLEV for the treatment of endogenous Cushing's syndrome have not been established.

  • 20

    Mar

  • 05

    Apr

SBBP Strongbridge Biopharma
$8.00

0.2 (2.56%)

08/10/17
OPCO
08/10/17
INITIATION
Target $12
OPCO
Outperform
Strongbridge Biopharma initiated with an Outperform at Oppenheimer
Oppenheimer analyst Hartaj Singh started Strongbridge Biopharma with an Outperform rating and $12 price target. The company's two assets, Keveyis and Recorlev, both have "proven clinical data and prior use in their respective therapeutic categories," the analyst contends. He's "bullish on the story."
08/11/17
08/11/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Strongbridge Biopharma (SBBP) initiated with an Outperform at Oppenheimer. 2. Discovery (DISCA) initiated with a Neutral at Piper Jaffray. 3. MannKind (MNKD) initiated with a Buy at Maxim. 4. Veritone (VERI) initiated with a Buy at Roth Capital. 5. Esperion (ESPR) initiated with a Neutral at BofA/Merrill. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
12/05/17
CANT
12/05/17
INITIATION
Target $14
CANT
Overweight
Strongbridge Biopharma initiated with an Overweight at Cantor Fitzgerald
Cantor Fitzgerald started Strongbridge Biopharma with an Overweight rating and $14 price target.
12/06/17
CANT
12/06/17
INITIATION
Target $14
CANT
Overweight
Cantor calls Strongbridge 'significantly undervalued' in initiation report
Cantor Fitzgerald analyst Elemer Piros last night initiated coverage of Strongbridge Biopharma with an Overweight rating and $14 price target. The analyst believes the ongoing commercialization of ultra orphan drug Keveyis in primary periodic paralysis as well as late-stage development of Recorlev in Cushing's makes Strongbridge attractive. Success on either front could drive a "major inflection point for the shares," the analyst contends. Piros views the company as "significantly undervalued."

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