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INCY

Incyte

$83.07

-0.91 (-1.08%)

, MRK

Merck

$54.53

-0.01 (-0.02%)

07:37
04/06/18
04/06
07:37
04/06/18
07:37

Incyte, Merck announce ECHO-301/KEYNOTE-252 study did not meet endpoints

Incyte (INCY) and Merck (MRK) announced that an external Data Monitoring Committee, or eDMC, review of the pivotal Phase 3 ECHO-301/KEYNOTE-252 study results evaluating Incyte's epacadostat in combination with Merck's Keytruda in patients with unresectable or metastatic melanoma determined that the study did not meet the primary endpoint of improving progression-free survival in the overall population compared to Keytruda monotherapy. The study's second primary endpoint of overall survival also is not expected to reach statistical significance. Based on these results, and at the recommendation of the eDMC, the study will be stopped. The safety profile observed in ECHO-301/KEYNOTE-252 was consistent with that observed in previously reported studies of epacadostat in combination with Keytruda. Incyte and Merck will inform investigators of the results and work with investigators to appropriately conclude the study in a manner consistent with the best interests of each patient. Data from this study will be analyzed and submitted for presentation at an upcoming scientific congress.

INCY

Incyte

$83.07

-0.91 (-1.08%)

MRK

Merck

$54.53

-0.01 (-0.02%)

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INCY Incyte
$83.07

-0.91 (-1.08%)

01/16/18
MZHO
01/16/18
DOWNGRADE
Target $23
MZHO
Neutral
Concert Pharmaceuticals downgraded to Neutral from Buy at Mizuho
Mizuho downgraded Concert Pharmaceuticals (CNCE) to Neutral with a $23 price target after the Patent Trial and Appeal Board did not grant the company a Post Grant Review in the ongoing Patent '355 dispute with Incyte Pharma (INCY). While the firm believes this development has no implications for the ultimate outcome of the trial, it does mean the litigation overhang will remain in the foreseeable future. Further, Mizuho sees the stock as fairly valued.
01/22/18
OPCO
01/22/18
NO CHANGE
Target $110
OPCO
Perform
Incyte price target lowered to $110 from $120 at Oppenheimer
Oppenheimer analyst Jay Olson lowered his price target for Incyte to $110 from $120 as he now sees a higher hurdle in NSCLC for epa and consequently lower probability of success than previously. The analyst reiterates a Perform rating on the shares.
02/15/18
BMOC
02/15/18
NO CHANGE
BMOC
Incyte risk/reward is favorable, says BMO Capital
04/05/18
LEHM
04/05/18
NO CHANGE
LEHM
Barclays upgrades Merck, downgrades Biogen and Pfizer in sector reassessment
Barclays analyst Geoff Meacham made some rating changes while reassessing the Biopharmaceutical sector. Biopharma sentiment has been negative since the start of 2018, despite a modest pick-up in deals and diminished rhetoric on drug pricing, Meacham tells investors in a research note titled "U.S. Biopharmaceuticals: Where to from here?" The analyst believes "more transformative" acquisitions, "clean" Phase 3 wins, and even a relatively strong Q1 earnings season could help "re-rate the sector" and get investors more engaged in the group. Ahead of the Q1 earnings season, Meacham upgraded Merck (MRK) to Overweight from Equal Weight and downgraded to Equal Weight from Overweight shares of Biogen (BIIB), Pfizer (PFE), Biohaven Pharmaceutical (BHVN) and Myovant Sciences (MYOV). The analyst also lowered his price target for Equal Weight-rated AbbVie (ABBV) to $102 from $120, for Equal Weight-rated Amgen (AMGN) to $180 from $180, for Overweight-rated Prothena (PRTA) to $50 from $70 and for Overweight-rated Incyte (INCY) to $135 from $165.
MRK Merck
$54.53

-0.01 (-0.02%)

03/12/18
03/12/18
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Time Warner (TWX) upgraded to Buy from Neutral at UBS with analyst John Hodulik saying while he expects the takeover by AT&T (T) to receive regulatory approval, he believes the current environment would make Time Warner's assets "highly attractive" to other media companies and Internet-based competitors were the deal to be blocked. 2. Carlyle Group (CG) and Apollo Global (APO) were upgraded to Buy from Neutral at Citi. 3. Merck (MRK) upgraded to Outperform from Market Perform at Leerink with analyst Seamus Fernandez saying Keytruda will continue to dominate the first-line non-small cell lung cancer market. 4. SAP (SAP) upgraded to Outperform from In Line at Evercore ISI with analyst Stewart Materne III saying that he believes the risk/reward is more attractive at current levels following the stock's 6% pullback. 5. Aratana Therapeutics (PETX) upgraded to Buy on valuation at CL King with the firm citing favorable risk/reward. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
04/05/18
LEHM
04/05/18
UPGRADE
Target $64
LEHM
Overweight
Merck upgraded to Overweight from Equal Weight at Barclays
Barclays analyst Geoffrey Meacham upgraded Merck to Overweight and raised his price target for the shares to $64 from $62. The analyst believes the company will continue to take share in first-line lung cancer, driven by positive KN-189 and KN-042 data.
04/05/18
04/05/18
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Merck (MRK) upgraded to Overweight from Equal Weight at Barclays with analyst Geoffrey Meacham saying he believes the company will continue to take share in first-line lung cancer, driven by positive KN-189 and KN-042 data. 2. Acuity Brands (AYI) upgraded to Outperform from Market Perform at JMP Securities with analyst Joseph Osha saying he believes the stock is finally trading at a "reasonable valuation based on reasonable expectations." 3. AMD (AMD) upgraded to Buy from Hold at Stifel with analyst Kevin Cassidy citing valuation and the company's margin expansion potential. 4. Tiffany (TIF) upgraded to Buy from Hold at Loop Capital with analyst Laura Champine saying her initial meeting with the company's new CEO Alessandro Bogliogo added to her confidence. 5. Citi (C) and Wells Fargo (WFC) were upgraded to Buy from Neutral at UBS. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

VNOM

Viper Energy

$38.34

0.91 (2.43%)

21:49
08/16/18
08/16
21:49
08/16/18
21:49
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Viper Energy rating change  »

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LIFE

aTyr Pharma

$0.63

(0.00%)

21:45
08/16/18
08/16
21:45
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21:45
Upgrade
aTyr Pharma rating change  »

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HLT

Hilton

$77.25

1.04 (1.36%)

21:44
08/16/18
08/16
21:44
08/16/18
21:44
Downgrade
Hilton rating change  »

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TSLA

Tesla

$335.46

-3.2 (-0.94%)

20:50
08/16/18
08/16
20:50
08/16/18
20:50
Periodicals
Tesla Fremont facility workers left 3.5 hours early on Wednesday, BI reports »

Workers at Tesla's…

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  • 29

    Oct

SPX

S&P 500

$0.00

(0.00%)

, FXI

iShares China Large-Cap ETF

$41.00

0.41 (1.01%)

20:43
08/16/18
08/16
20:43
08/16/18
20:43
Periodicals
Pentagon: China expanded bomber training to overwater areas, Reuters says »

In its annual report, the…

SPX

S&P 500

$0.00

(0.00%)

FXI

iShares China Large-Cap ETF

$41.00

0.41 (1.01%)

BA

Boeing

$345.89

14.16 (4.27%)

HII

Huntington Ingalls

$244.50

3.68 (1.53%)

LMT

Lockheed Martin

$325.86

8.31 (2.62%)

NOC

Northrop Grumman

$291.97

0.45 (0.15%)

03/08/13
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DE

Deere

$137.38

1.68 (1.24%)

20:25
08/16/18
08/16
20:25
08/16/18
20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

03/08/13
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  • 17

    Aug

MCD

McDonald's

$161.71

1.82 (1.14%)

19:48
08/16/18
08/16
19:48
08/16/18
19:48
Hot Stocks
FDA updates on investigation of McDonald's salad-related Cyclospora illnesses »

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  • 24

    Sep

TRP

TransCanada

$43.82

0.05 (0.11%)

19:40
08/16/18
08/16
19:40
08/16/18
19:40
Hot Stocks
TransCanada does not endorse mini-tender by TRC Capital »

TransCanada has been…

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SGMS

Scientific Games

$30.70

1.4 (4.78%)

, INSE

Inspired Entertainment

$7.15

(0.00%)

19:21
08/16/18
08/16
19:21
08/16/18
19:21
Hot Stocks
Scientific Games and Pennsylvania Lottery launch virtual sports »

Scientific Games (SGMS)…

SGMS

Scientific Games

$30.70

1.4 (4.78%)

INSE

Inspired Entertainment

$7.15

(0.00%)

03/08/13
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03/06/13
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03/06/13
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KRYS

Krystal Biotech

$15.63

0.23 (1.49%)

19:19
08/16/18
08/16
19:19
08/16/18
19:19
Syndicate
Krystal Biotech announces $10M private placement with Frazier Healthcare »

Krystal Biotech announced…

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  • 04

    Sep

LBC

Luther Burbank

$10.90

-0.09 (-0.82%)

19:08
08/16/18
08/16
19:08
08/16/18
19:08
Hot Stocks
Luther Burbank authorizes stock buyback of up to $15M »

Luther Burbank…

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  • 04

    Sep

ARAY

Accuray

$3.50

0.05 (1.45%)

, JWN

Nordstrom

$52.30

0.44 (0.85%)

19:00
08/16/18
08/16
19:00
08/16/18
19:00
Hot Stocks
On The Fly: After Hours Movers »

UP AFTER EARNINGS:…

ARAY

Accuray

$3.50

0.05 (1.45%)

JWN

Nordstrom

$52.30

0.44 (0.85%)

CRMT

America's Car-Mart

$66.95

1.85 (2.84%)

ATAI

ATA Inc.

$6.87

0.13 (1.93%)

CORT

Corcept Therapeutics

$12.51

0.01 (0.08%)

VJET

voxeljet

$3.51

0.11 (3.24%)

VNET

21Vianet

$9.45

0.44 (4.88%)

ATGE

Adtalem Global Education

$55.70

-0.3 (-0.54%)

NVDA

Nvidia

$257.57

-1.41 (-0.54%)

AMAT

Applied Materials

$47.42

-0.07 (-0.15%)

MU

Micron

$47.10

-0.38 (-0.80%)

LRCX

Lam Research

$174.22

1.42 (0.82%)

ZOES

Zoe's Kitchen

$9.52

0.04 (0.42%)

VCEL

Vericel

$11.50

-0.075 (-0.65%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 06

    Nov

NVEE

NV5 Global

$84.05

1.55 (1.88%)

18:55
08/16/18
08/16
18:55
08/16/18
18:55
Hot Stocks
NV5 Global CEO sells 190,500 common shares »

In a regulatory filing,…

03/08/13
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  • 13

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GOOG

Alphabet

$1,206.00

-7.65 (-0.63%)

, GOOGL

Alphabet Class A

$1,223.55

-8.75 (-0.71%)

18:54
08/16/18
08/16
18:54
08/16/18
18:54
Periodicals
Google submits plans for Moffett Park development, SVBJ reports »

Alphabet's Google…

GOOG

Alphabet

$1,206.00

-7.65 (-0.63%)

GOOGL

Alphabet Class A

$1,223.55

-8.75 (-0.71%)

03/08/13
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  • 22

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WMT

Walmart

$98.63

8.39 (9.30%)

18:38
08/16/18
08/16
18:38
08/16/18
18:38
Recommendations
Walmart analyst commentary at Baird »

Walmart price target…

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  • 16

    Aug

AVEO

Aveo Pharmaceuticals

$2.26

0.085 (3.91%)

18:35
08/16/18
08/16
18:35
08/16/18
18:35
Syndicate
Aveo Pharmaceuticals files to sell common stock, no amount given »

Piper Jaffray & Co.…

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  • 04

    Sep

ZN

Zion Oil & Gas

$2.53

0.16 (6.75%)

18:15
08/16/18
08/16
18:15
08/16/18
18:15
Hot Stocks
Zion Oil & Gas confirms active petroleum system in Megiddo-Jezreel #1 well »

Zion Oil & Gas…

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AMRS

Amyris

$7.49

0.07 (0.94%)

18:14
08/16/18
08/16
18:14
08/16/18
18:14
Syndicate
Amyris files to sell 7.4M shares of common stock for holders »

In connection with the…

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CORT

Corcept Therapeutics

$12.51

0.01 (0.08%)

18:07
08/16/18
08/16
18:07
08/16/18
18:07
Hot Stocks
Corcept Therapeutics board member Leonard Baker buys $2.2M in common stock »

Corcept Therapeutics…

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  • 04

    Sep

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ETSY

Etsy

$45.68

0.83 (1.85%)

17:44
08/16/18
08/16
17:44
08/16/18
17:44
Hot Stocks
Etsy chairman Frederick Wilson sells $1M in common stock »

Etsy chairman Frederick…

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  • 04

    Sep

NVDA

Nvidia

$257.57

-1.41 (-0.54%)

, TCEHY

Tencent

$0.00

(0.00%)

17:37
08/16/18
08/16
17:37
08/16/18
17:37
Hot Stocks
Nvidia says 'Fortnite,' 'PUBG' have strengthened video game market »

Nvidia (NVDA) says gaming…

NVDA

Nvidia

$257.57

-1.41 (-0.54%)

TCEHY

Tencent

$0.00

(0.00%)

DIS

Disney

$112.49

-0.42 (-0.37%)

MSFT

Microsoft

$107.65

-0.02 (-0.02%)

03/08/13
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  • 16

    Aug

  • 04

    Sep

  • 12

    Sep

RCUS

Arcus Biosciences

$12.89

-0.05 (-0.39%)

17:37
08/16/18
08/16
17:37
08/16/18
17:37
Hot Stocks
Arcus Biosciences CEO Terry Rosen buys over 28K shares of company stock »

Arcus Biosciences CEO…

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  • 12

    Sep

GLD

SPDR Gold Trust

$111.11

-0.1 (-0.09%)

17:30
08/16/18
08/16
17:30
08/16/18
17:30
Hot Stocks
SPDR Gold Trust holdings fall to 773.41MT from 774.59MT »

This is the 4th…

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FSTR

L.B. Foster

$23.05

-0.1 (-0.43%)

17:28
08/16/18
08/16
17:28
08/16/18
17:28
Hot Stocks
Breaking Hot Stocks news story on L.B. Foster »

Legion Partners lowers…

03/08/13
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HALO

Halozyme

$17.10

-0.1 (-0.58%)

17:25
08/16/18
08/16
17:25
08/16/18
17:25
Hot Stocks
Halozyme director and beneficial owner Randal Kirk sells over 490K shares »

Halozyme director and…

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  • 05

    Sep

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