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INCY

Incyte

$83.07

-0.91 (-1.08%)

, MRK

Merck

$54.53

-0.01 (-0.02%)

07:37
04/06/18
04/06
07:37
04/06/18
07:37

Incyte, Merck announce ECHO-301/KEYNOTE-252 study did not meet endpoints

Incyte (INCY) and Merck (MRK) announced that an external Data Monitoring Committee, or eDMC, review of the pivotal Phase 3 ECHO-301/KEYNOTE-252 study results evaluating Incyte's epacadostat in combination with Merck's Keytruda in patients with unresectable or metastatic melanoma determined that the study did not meet the primary endpoint of improving progression-free survival in the overall population compared to Keytruda monotherapy. The study's second primary endpoint of overall survival also is not expected to reach statistical significance. Based on these results, and at the recommendation of the eDMC, the study will be stopped. The safety profile observed in ECHO-301/KEYNOTE-252 was consistent with that observed in previously reported studies of epacadostat in combination with Keytruda. Incyte and Merck will inform investigators of the results and work with investigators to appropriately conclude the study in a manner consistent with the best interests of each patient. Data from this study will be analyzed and submitted for presentation at an upcoming scientific congress.

INCY

Incyte

$83.07

-0.91 (-1.08%)

MRK

Merck

$54.53

-0.01 (-0.02%)

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INCY Incyte
$83.07

-0.91 (-1.08%)

04/05/18
LEHM
04/05/18
NO CHANGE
LEHM
Barclays upgrades Merck, downgrades Biogen and Pfizer in sector reassessment
Barclays analyst Geoff Meacham made some rating changes while reassessing the Biopharmaceutical sector. Biopharma sentiment has been negative since the start of 2018, despite a modest pick-up in deals and diminished rhetoric on drug pricing, Meacham tells investors in a research note titled "U.S. Biopharmaceuticals: Where to from here?" The analyst believes "more transformative" acquisitions, "clean" Phase 3 wins, and even a relatively strong Q1 earnings season could help "re-rate the sector" and get investors more engaged in the group. Ahead of the Q1 earnings season, Meacham upgraded Merck (MRK) to Overweight from Equal Weight and downgraded to Equal Weight from Overweight shares of Biogen (BIIB), Pfizer (PFE), Biohaven Pharmaceutical (BHVN) and Myovant Sciences (MYOV). The analyst also lowered his price target for Equal Weight-rated AbbVie (ABBV) to $102 from $120, for Equal Weight-rated Amgen (AMGN) to $180 from $180, for Overweight-rated Prothena (PRTA) to $50 from $70 and for Overweight-rated Incyte (INCY) to $135 from $165.
02/15/18
BMOC
02/15/18
NO CHANGE
BMOC
Incyte risk/reward is favorable, says BMO Capital
01/22/18
OPCO
01/22/18
NO CHANGE
Target $110
OPCO
Perform
Incyte price target lowered to $110 from $120 at Oppenheimer
Oppenheimer analyst Jay Olson lowered his price target for Incyte to $110 from $120 as he now sees a higher hurdle in NSCLC for epa and consequently lower probability of success than previously. The analyst reiterates a Perform rating on the shares.
01/16/18
MZHO
01/16/18
DOWNGRADE
Target $23
MZHO
Neutral
Concert Pharmaceuticals downgraded to Neutral from Buy at Mizuho
Mizuho downgraded Concert Pharmaceuticals (CNCE) to Neutral with a $23 price target after the Patent Trial and Appeal Board did not grant the company a Post Grant Review in the ongoing Patent '355 dispute with Incyte Pharma (INCY). While the firm believes this development has no implications for the ultimate outcome of the trial, it does mean the litigation overhang will remain in the foreseeable future. Further, Mizuho sees the stock as fairly valued.
MRK Merck
$54.53

-0.01 (-0.02%)

04/05/18
04/05/18
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Merck (MRK) upgraded to Overweight from Equal Weight at Barclays with analyst Geoffrey Meacham saying he believes the company will continue to take share in first-line lung cancer, driven by positive KN-189 and KN-042 data. 2. Acuity Brands (AYI) upgraded to Outperform from Market Perform at JMP Securities with analyst Joseph Osha saying he believes the stock is finally trading at a "reasonable valuation based on reasonable expectations." 3. AMD (AMD) upgraded to Buy from Hold at Stifel with analyst Kevin Cassidy citing valuation and the company's margin expansion potential. 4. Tiffany (TIF) upgraded to Buy from Hold at Loop Capital with analyst Laura Champine saying her initial meeting with the company's new CEO Alessandro Bogliogo added to her confidence. 5. Citi (C) and Wells Fargo (WFC) were upgraded to Buy from Neutral at UBS. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
04/05/18
LEHM
04/05/18
UPGRADE
Target $64
LEHM
Overweight
Merck upgraded to Overweight from Equal Weight at Barclays
Barclays analyst Geoffrey Meacham upgraded Merck to Overweight and raised his price target for the shares to $64 from $62. The analyst believes the company will continue to take share in first-line lung cancer, driven by positive KN-189 and KN-042 data.
03/12/18
03/12/18
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Time Warner (TWX) upgraded to Buy from Neutral at UBS with analyst John Hodulik saying while he expects the takeover by AT&T (T) to receive regulatory approval, he believes the current environment would make Time Warner's assets "highly attractive" to other media companies and Internet-based competitors were the deal to be blocked. 2. Carlyle Group (CG) and Apollo Global (APO) were upgraded to Buy from Neutral at Citi. 3. Merck (MRK) upgraded to Outperform from Market Perform at Leerink with analyst Seamus Fernandez saying Keytruda will continue to dominate the first-line non-small cell lung cancer market. 4. SAP (SAP) upgraded to Outperform from In Line at Evercore ISI with analyst Stewart Materne III saying that he believes the risk/reward is more attractive at current levels following the stock's 6% pullback. 5. Aratana Therapeutics (PETX) upgraded to Buy on valuation at CL King with the firm citing favorable risk/reward. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

CNMD

CONMED

$63.14

1.36 (2.20%)

21:15
04/25/18
04/25
21:15
04/25/18
21:15
Recommendations
CONMED analyst commentary at Piper Jaffray »

CONMED price target…

03/08/13
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03/06/13
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03/06/13
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SSNLF

Samsung

20:48
04/25/18
04/25
20:48
04/25/18
20:48
Hot Stocks
Samsung sees Q2 DRAM demand to stay solid and NAND demand to strengthen »

Sees Q2 demand for…

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03/08/13
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03/06/13
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03/06/13
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  • 18

    May

AXS

Axis Capital

$56.82

-0.255 (-0.45%)

20:34
04/25/18
04/25
20:34
04/25/18
20:34
Earnings
Axis Capital reports Q1 adjusted EPS $1.46, consensus $1.16 »

Reports Q1 revenue…

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 26

    Apr

VERI

Veritone

$16.92

-0.18 (-1.05%)

20:31
04/25/18
04/25
20:31
04/25/18
20:31
Hot Stocks
Veritone to integrate BrainChip Holding AI machine learning applications »

BrainChip Holdings…

03/08/13
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03/08/13
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03/06/13
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03/06/13
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    May

ENB

Enbridge

$29.27

-0.13 (-0.44%)

, EEP

Enbridge Energy

$10.55

0.29 (2.83%)

20:28
04/25/18
04/25
20:28
04/25/18
20:28
Hot Stocks
Enbridge completes assessment of judge recommendations on Line 3 replacement »

After review of the…

ENB

Enbridge

$29.27

-0.13 (-0.44%)

EEP

Enbridge Energy

$10.55

0.29 (2.83%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
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03/06/13
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  • 09

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    May

PEP

PepsiCo

$101.11

-0.32 (-0.32%)

, ABBV

AbbVie

$91.91

0.57 (0.62%)

20:25
04/25/18
04/25
20:25
04/25/18
20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

PEP

PepsiCo

$101.11

-0.32 (-0.32%)

ABBV

AbbVie

$91.91

0.57 (0.62%)

UNP

Union Pacific

$136.11

3.3 (2.48%)

UPS

UPS

$108.54

0.34 (0.31%)

BMY

Bristol-Myers

$51.78

0.2 (0.39%)

COP

ConocoPhillips

$65.07

-0.24 (-0.37%)

TWX

Time Warner

$96.27

0.25 (0.26%)

RTN

Raytheon

$213.25

-5.5 (-2.51%)

CME

CME Group

$161.07

-0.52 (-0.32%)

GM

General Motors

$38.10

0.18 (0.47%)

ITW

Illinois Tool Works

$151.68

2.1 (1.40%)

SPGI

S&P Global

$189.68

0.62 (0.33%)

VLO

Valero

$108.68

0.37 (0.34%)

PX

Praxair

$149.84

3.05 (2.08%)

LUV

Southwest

$53.85

-0.03 (-0.06%)

HLT

Hilton

$81.85

-0.19 (-0.23%)

RCL

Royal Caribbean

$118.49

1.2 (1.02%)

ALXN

Alexion

$106.07

-0.37 (-0.35%)

IP

International Paper

$53.44

0.68 (1.29%)

MGM

MGM Resorts

$35.32

-0.2 (-0.56%)

HSY

Hershey

$93.51

0.7 (0.75%)

DHI

D.R. Horton

$44.94

1.195 (2.73%)

NLSN

Nielsen

$34.34

0.835 (2.49%)

DPZ

Domino's Pizza

$233.00

0.925 (0.40%)

TSCO

Tractor Supply

$62.21

1 (1.63%)

DNKN

Dunkin' Brands

$62.13

0.92 (1.50%)

CRI

Carter's

$104.96

0.95 (0.91%)

TREE

LendingTree

$307.20

-20.45 (-6.24%)

SAVE

Spirit Airlines

$37.64

-0.615 (-1.61%)

KBR

KBR

$16.02

-0.255 (-1.57%)

03/08/13
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03/08/13
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03/06/13
Citigroup
03/06/13
Barclays

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ROK

Rockwell Automation

$167.30

5.335 (3.29%)

20:08
04/25/18
04/25
20:08
04/25/18
20:08
Downgrade
Rockwell Automation rating change at Vertical Research »

Rockwell Automation…

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 25

    Apr

SNDE

Sundance Energy

$4.53

-0.03 (-0.66%)

, PXD

Pioneer Natural

$198.97

2.96 (1.51%)

20:02
04/25/18
04/25
20:02
04/25/18
20:02
Hot Stocks
Sundance Energy Australia acquires Eagle Ford assets, announces equity raise »

Sundance Energy Australia…

SNDE

Sundance Energy

$4.53

-0.03 (-0.66%)

PXD

Pioneer Natural

$198.97

2.96 (1.51%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
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  • 03

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    May

SSNLF

Samsung

19:51
04/25/18
04/25
19:51
04/25/18
19:51
Earnings
Samsung reports Q1 net profit KRW 11.61T »

Compares to…

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 18

    May

CHKP

Check Point

$96.33

-6.62 (-6.43%)

19:42
04/25/18
04/25
19:42
04/25/18
19:42
Recommendations
Check Point analyst commentary at Jefferies »

Check Point price target…

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03/08/13
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03/06/13
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03/06/13
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  • 25

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QTS

QTS Realty Trust

$34.04

0.31 (0.92%)

19:35
04/25/18
04/25
19:35
04/25/18
19:35
Recommendations
QTS Realty Trust analyst commentary at MUFG »

QTS Realty Trust price…

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  • 01

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STB

Student Transportation

19:23
04/25/18
04/25
19:23
04/25/18
19:23
Hot Stocks
Student Transportation obtains court order approving Spinner Can Acquireco deal »

Student Transportation is…

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NCMGY

Newcrest Mining

19:15
04/25/18
04/25
19:15
04/25/18
19:15
Hot Stocks
Newcrest Mining reports Q3 gold production 576K oz, down 6% from last quarter »

Reports Q3 copper…

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PSA

Public Storage

$193.62

-0.115 (-0.06%)

19:04
04/25/18
04/25
19:04
04/25/18
19:04
Hot Stocks
Public Storage names Natalia Johnson chief HR officer »

Ronald L. Havner, Jr.,…

03/08/13
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03/06/13
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03/06/13
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CADE

Cadence Bancorp

$28.80

-0.14 (-0.48%)

19:03
04/25/18
04/25
19:03
04/25/18
19:03
Earnings
Cadence Bancorp reports Q1 EPS 46c, consensus 44c »

Reports Q1 revenue…

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 26

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USAK

USA Truck

$25.56

-0.84 (-3.18%)

19:02
04/25/18
04/25
19:02
04/25/18
19:02
Hot Stocks
USA Truck names Tim Guin as EVP and Chief Commercial Officer »

USA Truck announced that…

03/08/13
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03/06/13
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03/06/13
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  • 27

    Apr

BCS

Barclays

$12.01

-0.085 (-0.70%)

, PYPL

PayPal

$74.00

-1.29 (-1.71%)

19:01
04/25/18
04/25
19:01
04/25/18
19:01
Hot Stocks
Barclays, PayPal announces strategic partnership »

Barclays (BCS) announced…

BCS

Barclays

$12.01

-0.085 (-0.70%)

PYPL

PayPal

$74.00

-1.29 (-1.71%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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    Jun

ORLY

O'Reilly Automotive

$228.03

3.31 (1.47%)

, CMG

Chipotle

$339.30

6.4 (1.92%)

19:00
04/25/18
04/25
19:00
04/25/18
19:00
Hot Stocks
On The Fly: After Hours Movers »

UP AFTER EARNINGS:…

ORLY

O'Reilly Automotive

$228.03

3.31 (1.47%)

CMG

Chipotle

$339.30

6.4 (1.92%)

PCMI

PCM, Inc.

$10.60

0.1 (0.95%)

AMD

AMD

$9.72

-0.37 (-3.67%)

FB

Facebook

$159.69

0.03 (0.02%)

ECHO

Echo Global

$27.80

0.15 (0.54%)

XLNX

Xilinx

$63.70

-0.34 (-0.53%)

PYPL

PayPal

$74.00

-1.29 (-1.71%)

ALGN

Align Technology

$245.24

5.72 (2.39%)

CTXS

Citrix

$96.54

0.04 (0.04%)

V

Visa

$121.00

-0.41 (-0.34%)

CLGX

CoreLogic

$43.85

-0.57 (-1.28%)

F

Ford

$11.11

0.16 (1.46%)

QCOM

Qualcomm

$49.77

-0.17 (-0.34%)

LVS

Las Vegas Sands

$72.42

-1.38 (-1.87%)

LM

Legg Mason

$37.64

0.25 (0.67%)

INTU

Intuit

$176.38

-2.25 (-1.26%)

TWTR

Twitter

$29.88

-0.6 (-1.97%)

FARO

FARO Technologies

$60.50

-1.85 (-2.97%)

LMAT

LeMaitre

$39.00

0.19 (0.49%)

UHS

Universal Health

$122.03

1.5 (1.24%)

EBAY

eBay

$40.98

-0.2 (-0.49%)

T

AT&T

$35.19

0.19 (0.54%)

KEX

Kirby

$82.95

-1.85 (-2.18%)

GG

Goldcorp

$13.97

-0.38 (-2.65%)

BMRN

BioMarin

$81.41

0.33 (0.41%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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NBIX

Neurocrine

$78.13

-0.3 (-0.38%)

18:59
04/25/18
04/25
18:59
04/25/18
18:59
Hot Stocks
Neurocrine says Ingrezza improved TD symptoms regardless of body region »

Neurocrine Biosciences…

03/08/13
Wedge Partners
03/08/13
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03/06/13
Citigroup
03/06/13
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  • 30

    Apr

AZPN

Aspen Technology

$85.50

0.39 (0.46%)

18:54
04/25/18
04/25
18:54
04/25/18
18:54
Earnings
Aspen Technology raises FY18 adj. EPS view to $2.24-$2.27 from $2.16-$2.21 »

Consensus $2.21. Raises…

03/08/13
Wedge Partners
03/08/13
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03/06/13
Citigroup
03/06/13
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  • 25

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    Jun

AZPN

Aspen Technology

$85.50

0.39 (0.46%)

18:53
04/25/18
04/25
18:53
04/25/18
18:53
Earnings
Aspen Technology sees Q4 adjusted EPS 53c-55c, consensus 57c »

Sees Q4 revenue…

03/08/13
Wedge Partners
03/08/13
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03/06/13
Citigroup
03/06/13
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  • 25

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    Jun

ESV

Ensco

$6.03

-0.15 (-2.43%)

18:52
04/25/18
04/25
18:52
04/25/18
18:52
Earnings
Ensco reports Q1 adjusted EPS (32c), consensus (27c) »

Reports Q1 revenue…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

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  • 26

    Apr

CLB

Core Laboratories

$120.25

2.07 (1.75%)

18:50
04/25/18
04/25
18:50
04/25/18
18:50
Earnings
Core Laboratories sees Q2 EPS 64c-66c, consensus 66c »

Expects Q2 revenue…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

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  • 26

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    May

SPY

SPDR S&P 500 ETF Trust

$263.64

0.52 (0.20%)

, SPX

S&P 500

18:47
04/25/18
04/25
18:47
04/25/18
18:47
Periodicals
Breaking Periodicals news story on SPDR S&P 500 ETF Trust, S&P 500 »

France's Macron sees…

SPY

SPDR S&P 500 ETF Trust

$263.64

0.52 (0.20%)

SPX

S&P 500

03/08/13
Wedge Partners
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Credit Suisse
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Citigroup
03/06/13
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Samsung

18:41
04/25/18
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Periodicals
Breaking Periodicals news story on Samsung »

Samsung to sell Hanwha…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

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