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MRK

Merck

$53.36

-1.17 (-2.15%)

06:46
04/09/18
04/09
06:46
04/09/18
06:46

Merck: Phase 3 KEYNOTE-042 trial met primary endpoint of overall survival

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MRK Merck
$53.36

-1.17 (-2.15%)

04/06/18
WBLR
04/06/18
DOWNGRADE
WBLR
Market Perform
William Blair downgrades Incyte after metastatic melanoma study failure
William Blair analyst Katherine Xu downgraded Incyte (INCY) to Market Perform from Outperform after the company and partner Merck (MRK) announced that ECHO-301 did not meet one of the primary endpoints of improving progression-free survival and that overall survival, the other co-primary endpoint, was not expected to be met either. After taking epacadostat out of her model, the analyst's fair value estimate for Incyte drops to $88 from $170. The stock in premarket trading is down 21%, or $17.08, to $65.99. It is unclear whether the biomarker data derived from ECHO-301 could guide other Phase III studies, and whether the other Phase III studies are to continue, Xu tells investors in a research note. She sees the next key catalysts for Incyte shares as the baricitinib advisory panel on April 23, and data from Jakafi Phase II pivotal REACH1 study in steroid-refractory acute graft-versus-host disease in the first half 2018.
04/06/18
CANT
04/06/18
NO CHANGE
Target $26
CANT
Overweight
Cantor says premature to assume NewLink trial will fail like Incyte's
NewLink Genetics' (NLNK) indoximod, which acts as a tryptophan mimetic rather than an IDO enzymatic inhibitor, has shown differentiated data versus Incyte's (INCY) epacadostat, Cantor Fitzgerald analyst Mara Goldstein tells investors in a research note. NewLink is trading down 37.5%, or $2.75, to $4.57 after Incyte announced that its ECHO-301 study of epacadostat plus Merck's (MRK) Keytruda versus Keytruda alone was unsuccessful in treating advanced melanoma. Goldstein thinks assuming failure of indoximod "may be premature," but she acknowledges that NewLink shares are likely to be pressured with the company's Phase III trial end likely over a year away. If indoximod is truly differentiated, however, NewLink shares will be higher than $26 given the "now likely limited competition," Goldstein contends. She reiterates an Overweight rating on the shares with a $26 price target.
04/06/18
MZHO
04/06/18
NO CHANGE
Target $103
MZHO
Buy
Mizuho says failure of Incyte's epacadostat ups chances of Nektar takeover
Mizuho analyst Difei Yang raised her price target on Nektar Therapeutics (NKTR) to $103 from $89 after Incyte (INCY) announced this morning the failure of epacadostat in combination with Merck's (MRK) Keytruda in a phase 3 study in melanoma patients. Recent clinical data presented by Nektar reinforced her view of NKTR-214 as one of the most impressive combo agent for checkpoint inhibitors, said Yang, who believes that the failure of epacadostat raises the possibility of a takeout by Bristol-Myers (BMY) in the coming months. She maintains a Buy rating on Nektar shares, which are down 8.5% to $92.75 in afternoon trading.
04/09/18
JEFF
04/09/18
DOWNGRADE
Target $4
JEFF
Hold
NewLink Genetics downgraded to Hold with $4 target at Jefferies
Jefferies analyst Biren Amin late Friday downgraded NewLink Genetics (NLNK) to Hold from Buy and cut his price target for the shares to $4 from $17. The stock closed Friday down 43%, or $3.12, to $4.20. The analyst does not see a scenario in which the company's IDO inhibitor can avoid the same fate as Incyte and Merck's epacadostat plus Keytruda failed study.

TODAY'S FREE FLY STORIES

OPTN

Optinose

$12.86

-6.64 (-34.05%)

15:28
08/14/18
08/14
15:28
08/14/18
15:28
Recommendations
Optinose analyst commentary  »

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BOOT

Boot Barn

$27.93

1.04 (3.87%)

15:20
08/14/18
08/14
15:20
08/14/18
15:20
Options
Sweep call buyers in Boot Barn as shares lift on heavy volume »

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    Aug

CREE

Cree

$49.94

-0.34 (-0.68%)

15:19
08/14/18
08/14
15:19
08/14/18
15:19
Options
Cree options imply 15.2% move in share price post-earnings, above median historical move »

Pre-earnings options…

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

15:17
08/14/18
08/14
15:17
08/14/18
15:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

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$NYE

NYSE Market Internals

$0.00

(0.00%)

15:16
08/14/18
08/14
15:16
08/14/18
15:16
Technical Analysis
NYSE market internals summary »

Volume is below average…

03/08/13
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CSBR

Champions Oncology

$7.80

0.315 (4.21%)

15:12
08/14/18
08/14
15:12
08/14/18
15:12
Conference/Events
Champions Oncology management to meet with Craig-Hallum »

.Meetings to be held in…

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GLF

GulfMark Offshore

$38.18

0.48 (1.27%)

15:10
08/14/18
08/14
15:10
08/14/18
15:10
Hot Stocks
Breaking Hot Stocks news story on GulfMark Offshore »

GulfMark Offshore Inc…

03/08/13
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SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$284.02

1.89 (0.67%)

15:06
08/14/18
08/14
15:06
08/14/18
15:06
Technical Analysis
Technical Take: SPDR S&P 500 ETF near session highs in final hour of trading »

The SPDR S&P 500 ETF…

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$284.02

1.89 (0.67%)

03/08/13
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A

Agilent

$67.01

1.06 (1.61%)

15:04
08/14/18
08/14
15:04
08/14/18
15:04
Options
Agilent options imply 9.7% move in share price post-earnings, above median historical move »

Pre-earnings options…

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CLF

Cleveland-Cliffs

$9.97

-0.235 (-2.30%)

15:00
08/14/18
08/14
15:00
08/14/18
15:00
Options
15K Cleveland Cliffs Aug - Oct 8 call spreads bought for 17c »

15K Cleveland Cliffs Aug…

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  • 11

    Sep

15:00
08/14/18
08/14
15:00
08/14/18
15:00
General news
Treasury Closing Summary: »

Treasury Closing Summary:…

WMT

Walmart

$90.90

1.24 (1.38%)

14:59
08/14/18
08/14
14:59
08/14/18
14:59
Hot Stocks
Walmart opens distribution center in Mobile, Alabama »

Walmart commemorated the…

03/08/13
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  • 16

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SPR

Spirit AeroSystems

$86.53

-0.23 (-0.27%)

14:57
08/14/18
08/14
14:57
08/14/18
14:57
Hot Stocks
Spirit AeroSystems VP Michelle Lohmeier sells almost $300K in company stock »

Spirit AeroSystems VP…

03/08/13
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SPOT

Spotify

$193.85

2.4 (1.25%)

, UXIN

Uxin

$5.54

-0.61 (-9.92%)

14:57
08/14/18
08/14
14:57
08/14/18
14:57
Hot Stocks
Tiger Global adds Spotify and Adobe, exits United Continental »

Chase Coleman's…

SPOT

Spotify

$193.85

2.4 (1.25%)

UXIN

Uxin

$5.54

-0.61 (-9.92%)

COUP

Coupa Software

$67.20

1.66 (2.53%)

ADBE

Adobe

$255.81

2.23 (0.88%)

GDS

GDS Holdings

$30.05

-2.58 (-7.91%)

EHIC

eHi Car Services

$12.90

0.05 (0.39%)

ARCC

Ares Capital

$17.37

0.015 (0.09%)

UAL

United Continental

$81.84

0.58 (0.71%)

TWTR

Twitter

$33.04

0.24 (0.73%)

FB

Facebook

$180.91

0.83 (0.46%)

NOW

ServiceNow

$184.66

-0.38 (-0.21%)

MLI

Mueller Industries

$31.95

0.18 (0.57%)

RUN

Sunrun

$12.99

-0.22 (-1.67%)

RDFN

Redfin

$18.04

-0.5 (-2.70%)

JD

JD.com

$33.55

-1.51 (-4.31%)

TDG

TransDigm

$355.86

-0.2 (-0.06%)

MSFT

Microsoft

$109.51

1.27 (1.17%)

AMZN

Amazon.com

$1,915.47

19.96 (1.05%)

03/08/13
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DENN

Denny's

$14.66

0.12 (0.83%)

14:53
08/14/18
08/14
14:53
08/14/18
14:53
Conference/Events
Denny's participates in a conference call with Stephens »

Conference call with…

03/08/13
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WPM

Wheaton Precious Metals

$19.94

-0.1 (-0.50%)

14:49
08/14/18
08/14
14:49
08/14/18
14:49
Options
Wheaton Precious Metals options imply 5.1% move in share price post-earnings, above median historical move »

Pre-earnings options…

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  • 15

    Aug

DWSN

Dawson Geophysical

$5.90

0.04 (0.68%)

14:48
08/14/18
08/14
14:48
08/14/18
14:48
Hot Stocks
Dawson Geophysical director William Barrett buys over $100K in stock »

Dawson Geophysical…

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FB

Facebook

$180.92

0.84 (0.47%)

, GOOG

Alphabet

$1,242.00

6.9 (0.56%)

14:48
08/14/18
08/14
14:48
08/14/18
14:48
Conference/Events
William Blair digital media analyst to hold a meeting »

Analysts, along with the…

FB

Facebook

$180.92

0.84 (0.47%)

GOOG

Alphabet

$1,242.00

6.9 (0.56%)

03/08/13
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    Oct

14:46
08/14/18
08/14
14:46
08/14/18
14:46
Conference/Events
William Blair SaaS analyst to hold a group luncheon »

Software as a Service…

GLF

GulfMark Offshore

$38.18

0.48 (1.27%)

14:45
08/14/18
08/14
14:45
08/14/18
14:45
Hot Stocks
Breaking Hot Stocks news story on GulfMark Offshore »

GulfMark Offshore Inc…

03/08/13
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KR

Kroger

$30.38

0.63 (2.12%)

, BABA

Alibaba

$171.94

-5.715 (-3.22%)

14:44
08/14/18
08/14
14:44
08/14/18
14:44
Hot Stocks
Kroger announces pilot for sales in China via Alibaba's Tmall platform »

Kroger (KR) announced a…

KR

Kroger

$30.38

0.63 (2.12%)

BABA

Alibaba

$171.94

-5.715 (-3.22%)

03/08/13
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03/06/13
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  • 23

    Aug

  • 10

    Sep

14:43
08/14/18
08/14
14:43
08/14/18
14:43
Conference/Events
Stephens retail/hardlines analyst to hold luncheon meeting »

Retail/Hardlines Analyst…

TWTR

Twitter

$33.03

0.23 (0.70%)

14:43
08/14/18
08/14
14:43
08/14/18
14:43
Hot Stocks
Twitter suspends accounts for trying to evade account suspension »

Twitter's Safety…

03/08/13
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  • 28

    Aug

PLNT

Planet Fitness

$51.74

2.75 (5.61%)

14:40
08/14/18
08/14
14:40
08/14/18
14:40
Options
Bullish flow in Planet Fitness as shares rebound »

Bullish flow in Planet…

03/08/13
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PYPL

PayPal

$87.59

0.56 (0.64%)

14:30
08/14/18
08/14
14:30
08/14/18
14:30
Options
Bullish option play opened in Paypal »

Bullish option play…

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