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MRK

Merck

$53.36

-1.17 (-2.15%)

06:46
04/09/18
04/09
06:46
04/09/18
06:46

Merck: Phase 3 KEYNOTE-042 trial met primary endpoint of overall survival

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MRK Merck
$53.36

-1.17 (-2.15%)

04/06/18
WBLR
04/06/18
DOWNGRADE
WBLR
Market Perform
William Blair downgrades Incyte after metastatic melanoma study failure
William Blair analyst Katherine Xu downgraded Incyte (INCY) to Market Perform from Outperform after the company and partner Merck (MRK) announced that ECHO-301 did not meet one of the primary endpoints of improving progression-free survival and that overall survival, the other co-primary endpoint, was not expected to be met either. After taking epacadostat out of her model, the analyst's fair value estimate for Incyte drops to $88 from $170. The stock in premarket trading is down 21%, or $17.08, to $65.99. It is unclear whether the biomarker data derived from ECHO-301 could guide other Phase III studies, and whether the other Phase III studies are to continue, Xu tells investors in a research note. She sees the next key catalysts for Incyte shares as the baricitinib advisory panel on April 23, and data from Jakafi Phase II pivotal REACH1 study in steroid-refractory acute graft-versus-host disease in the first half 2018.
04/06/18
CANT
04/06/18
NO CHANGE
Target $26
CANT
Overweight
Cantor says premature to assume NewLink trial will fail like Incyte's
NewLink Genetics' (NLNK) indoximod, which acts as a tryptophan mimetic rather than an IDO enzymatic inhibitor, has shown differentiated data versus Incyte's (INCY) epacadostat, Cantor Fitzgerald analyst Mara Goldstein tells investors in a research note. NewLink is trading down 37.5%, or $2.75, to $4.57 after Incyte announced that its ECHO-301 study of epacadostat plus Merck's (MRK) Keytruda versus Keytruda alone was unsuccessful in treating advanced melanoma. Goldstein thinks assuming failure of indoximod "may be premature," but she acknowledges that NewLink shares are likely to be pressured with the company's Phase III trial end likely over a year away. If indoximod is truly differentiated, however, NewLink shares will be higher than $26 given the "now likely limited competition," Goldstein contends. She reiterates an Overweight rating on the shares with a $26 price target.
04/06/18
MZHO
04/06/18
NO CHANGE
Target $103
MZHO
Buy
Mizuho says failure of Incyte's epacadostat ups chances of Nektar takeover
Mizuho analyst Difei Yang raised her price target on Nektar Therapeutics (NKTR) to $103 from $89 after Incyte (INCY) announced this morning the failure of epacadostat in combination with Merck's (MRK) Keytruda in a phase 3 study in melanoma patients. Recent clinical data presented by Nektar reinforced her view of NKTR-214 as one of the most impressive combo agent for checkpoint inhibitors, said Yang, who believes that the failure of epacadostat raises the possibility of a takeout by Bristol-Myers (BMY) in the coming months. She maintains a Buy rating on Nektar shares, which are down 8.5% to $92.75 in afternoon trading.
04/09/18
JEFF
04/09/18
DOWNGRADE
Target $4
JEFF
Hold
NewLink Genetics downgraded to Hold with $4 target at Jefferies
Jefferies analyst Biren Amin late Friday downgraded NewLink Genetics (NLNK) to Hold from Buy and cut his price target for the shares to $4 from $17. The stock closed Friday down 43%, or $3.12, to $4.20. The analyst does not see a scenario in which the company's IDO inhibitor can avoid the same fate as Incyte and Merck's epacadostat plus Keytruda failed study.

TODAY'S FREE FLY STORIES

ECOL

US Ecology

$70.69

-1.29 (-1.79%)

09:11
11/21/18
11/21
09:11
11/21/18
09:11
Hot Stocks
US Ecology sees FY18 at lower end of prior guidance after Grand View explosion »

In a regulatory 8-K…

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ZOES

Zoe's Kitchen

$12.75

(0.00%)

09:09
11/21/18
11/21
09:09
11/21/18
09:09
Hot Stocks
Breaking Hot Stocks news story on Zoe's Kitchen »

Zoes Kitchen trading…

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COLD

Americold Realty Trust

$26.11

-0.27 (-1.02%)

09:05
11/21/18
11/21
09:05
11/21/18
09:05
Recommendations
Americold Realty Trust analyst commentary  »

Americold Realty Trust…

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09:05
11/21/18
11/21
09:05
11/21/18
09:05
General news
Treasury Action: Treasury yields have slipped from earlier highs »

Treasury Action: Treasury…

TGP

Teekay LNG

$12.79

-0.77 (-5.68%)

09:04
11/21/18
11/21
09:04
11/21/18
09:04
Recommendations
Teekay LNG analyst commentary  »

Teekay LNG price target…

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LGND

Ligand

$149.14

0.46 (0.31%)

09:02
11/21/18
11/21
09:02
11/21/18
09:02
Hot Stocks
Ligand announces OmniAb partnership with iMetabolic Biopharma »

Ligand Pharmaceuticals…

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    Dec

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DE

Deere

$138.49

-4.04 (-2.83%)

, AGCO

Agco

$57.86

0.5 (0.87%)

09:01
11/21/18
11/21
09:01
11/21/18
09:01
Hot Stocks
Fly Intel: Pre-market Movers »

HIGHER: Amazon (AMZN), up…

DE

Deere

$138.49

-4.04 (-2.83%)

AGCO

Agco

$57.86

0.5 (0.87%)

AMZN

Amazon.com

$1,495.60

-16.07 (-1.06%)

FB

Facebook

$132.47

0.85 (0.65%)

FL

Foot Locker

$46.10

-2.69 (-5.51%)

GPS

Gap

$24.65

-0.79 (-3.11%)

ABIL

Ability

$2.83

-0.15 (-5.03%)

ADSK

Autodesk

$122.99

-2.76 (-2.19%)

BZUN

Baozun

$30.07

-0.98 (-3.16%)

BILI

Bilibili

$13.61

0.575 (4.41%)

03/08/13
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09:00
11/21/18
11/21
09:00
11/21/18
09:00
General news
U.S. equities rebounded from correction lows »

U.S. equities rebounded…

TSM

TSMC

$35.64

-0.41 (-1.14%)

, INTC

Intel

$47.38

-0.61 (-1.27%)

08:57
11/21/18
11/21
08:57
11/21/18
08:57
Periodicals
TSMC set to win 'major coup' with IBM server chip deal, Nikkei says »

Well-placed supply chain…

TSM

TSMC

$35.64

-0.41 (-1.14%)

INTC

Intel

$47.38

-0.61 (-1.27%)

IBM

IBM

$117.17

-3.2 (-2.66%)

03/08/13
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TJX

TJX

$46.81

-2.16 (-4.41%)

, BURL

Burlington Stores

$148.36

-8.145 (-5.20%)

08:56
11/21/18
11/21
08:56
11/21/18
08:56
Recommendations
TJX, Burlington Stores analyst commentary  »

TJX apparel category…

TJX

TJX

$46.81

-2.16 (-4.41%)

BURL

Burlington Stores

$148.36

-8.145 (-5.20%)

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  • 28

    Nov

DE

Deere

$138.49

-4.04 (-2.83%)

08:55
11/21/18
11/21
08:55
11/21/18
08:55
Technical Analysis
Technical Take: Deere falls after results »

The shares were last down…

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  • 21

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AAPL

Apple

$177.10

-8.7 (-4.68%)

, BAC

Bank of America

$27.39

-0.375 (-1.35%)

08:55
11/21/18
11/21
08:55
11/21/18
08:55
Options
Notable open interest changes for November 21st »

Tuesday's total…

AAPL

Apple

$177.10

-8.7 (-4.68%)

BAC

Bank of America

$27.39

-0.375 (-1.35%)

GE

General Electric

$7.67

-0.165 (-2.11%)

NVDA

Nvidia

$149.14

4.48 (3.10%)

03/08/13
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08:55
11/21/18
11/21
08:55
11/21/18
08:55
General news
The 3k initial claims rise to 224k »

The 3k initial claims…

ROST

Ross Stores

$82.65

-8.54 (-9.37%)

08:51
11/21/18
11/21
08:51
11/21/18
08:51
Recommendations
Ross Stores analyst commentary  »

Ross Stores price target…

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LMB

Limbach Holding

$4.85

-1.04 (-17.66%)

08:50
11/21/18
11/21
08:50
11/21/18
08:50
Downgrade
Limbach Holding rating change  »

Limbach Holding…

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AMZN

Amazon.com

$1,495.60

-16.07 (-1.06%)

, AAPL

Apple

$177.10

-8.7 (-4.68%)

08:50
11/21/18
11/21
08:50
11/21/18
08:50
Periodicals
Amazon working on getting Amazon Pay into physical stores, WSJ says »

Amazon (AMZN) is working…

AMZN

Amazon.com

$1,495.60

-16.07 (-1.06%)

AAPL

Apple

$177.10

-8.7 (-4.68%)

PYPL

PayPal

$77.76

-2.4 (-2.99%)

WMT

Walmart

$94.21

-2.59 (-2.68%)

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08:50
11/21/18
11/21
08:50
11/21/18
08:50
General news
FX Action: The dollar »

FX Action: The dollar…

08:45
11/21/18
11/21
08:45
11/21/18
08:45
General news
U.S. durable goods orders dropped 4.4% in October »

U.S. durable goods orders…

BGS

B&G Foods

$30.69

0.44 (1.45%)

, GGB

Gerdau

$4.11

-0.19 (-4.42%)

08:45
11/21/18
11/21
08:45
11/21/18
08:45
Options
Largest borrow rate increases among liquid names »

Latest data shows the…

BGS

B&G Foods

$30.69

0.44 (1.45%)

GGB

Gerdau

$4.11

-0.19 (-4.42%)

CRON

Cronos Group

$8.19

-0.05 (-0.61%)

QID

ProShares UltraShort QQQ

$46.41

1.57 (3.50%)

SSO

ProShares Ultra S&P 500

$104.01

-4.03 (-3.73%)

NEPT

Neptune Wellness

$3.10

-0.125 (-3.88%)

NFX

Newfield Exploration

$17.67

-1.69 (-8.73%)

CVX

Chevron

$116.19

-3.23 (-2.70%)

EWY

iShares MSCI South Korea Index Fund

$58.89

-1.05 (-1.75%)

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  • 26

    Nov

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    Dec

08:45
11/21/18
11/21
08:45
11/21/18
08:45
General news
Treasury Action: yields ebbed to lows »

Treasury Action: yields…

08:45
11/21/18
11/21
08:45
11/21/18
08:45
General news
U.S. initial jobless claims rose 3k in the week ended November 17 to 224k »

U.S. initial jobless…

BW

Babcock & Wilcox

$0.90

-0.0052 (-0.58%)

08:41
11/21/18
11/21
08:41
11/21/18
08:41
Conference/Events
Babcock & Wilcox to host conference call »

As previously announced…

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AZO

AutoZone

$793.73

-35.77 (-4.31%)

08:40
11/21/18
11/21
08:40
11/21/18
08:40
Recommendations
AutoZone analyst commentary  »

AutoZone price target…

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  • 04

    Dec

MUFG

Mitsubishi UFJ

$5.56

-0.005 (-0.09%)

08:40
11/21/18
11/21
08:40
11/21/18
08:40
Periodicals
U.S. prosecutors probing Mitsubishi UFJ money laundering controls, NY Times says »

Mitsubishi UFJ Financial,…

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DSX

Diana Shipping

$3.06

-0.11 (-3.47%)

08:40
11/21/18
11/21
08:40
11/21/18
08:40
Hot Stocks
Diana Shipping announces time charter contract for m/v Alcmeme with BG Shipping »

Diana Shipping announced…

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  • 26

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