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CAPR

Capricor Therapeutics

$1.43

-0.07 (-4.67%)

07:08
04/19/18
04/19
07:08
04/19/18
07:08

Capricor announces new pre-clinical data on CAP-1002

Capricor Therapeutics announced that researchers found that repeat dosing of the company's proprietary cellular therapy yields an increase in exercise performance in a disease model of Duchenne muscular dystrophy, the mdx mouse. The company has previously presented data showing that single doses lead to significant improvement in treadmill run times. In an abstract presentation at the 11th Annual Neuromuscular Translational Research Conference in Cambridge, England, researchers reported that while the therapy, CAP-1002, is recognized by the immune system, its low immunogenic profile and immunomodulatory capabilities allowed it to be administered multiple times without significant safety issues. They also reported that repeat dosing was shown to sustain the effect of the therapeutic. A previous clinical trial, the HOPE-Duchenne trial, found a single intracoronary dose of CAP-1002 was generally safe, well tolerated and demonstrated significant and sustained signals of improvement in cardiac and skeletal muscle function in boys and young men in advanced stages of Duchenne muscular dystrophy. The HOPE-2 clinical trial will test the safety and efficacy of repeat doses of CAP-1002 in boys and young men with Duchenne muscular dystrophy, a devastating and fatal genetic disorder with limited treatment options and no cure. Up to 84 boys and young men with Duchenne muscular dystrophy will be enrolled in the Phase 2, randomized, double-blind, placebo-controlled trial. HOPE-2 will test repeat doses of CAP-1002 in participants with advanced stages of Duchenne muscular dystrophy. Capricor has been granted the RMAT and orphan disease designations by the U.S. Food and Drug Administration. These designations will enable the company to work closely with the FDA in finalizing the regulatory approval pathway for CAP-1002 and to receive expedited FDA reviews.

CAPR Capricor Therapeutics
$1.43

-0.07 (-4.67%)

07/18/17
RODM
07/18/17
NO CHANGE
Target $2.15
RODM
Buy
FDA decision encouraging for Capricor Duchenne drug, says Rodman & Renshaw
Rodman & Renshaw analyst Joseph Pantginis notes that Capricor Therapeutics' CAP-1002 took an important regulatory step forward with the FDA granting Rare Pediatric Disease Designation for Duchenne muscular dystrophy. Should the positive CAP-1002 data continue to be positive and the therapy approved, Capricor could also be eligible for a Priority Review Voucher, or PRV, the analyst points out, adding that a key potential outcome to a PRV is not only an accelerated path to market, but the ability to sell the PRV for significant non-dilutive funding. Pantginis reiterates a Buy rating and $2.15 price target on the shares. In late morning trading, Capricor Therapeutics' stock has more than doubled to $1.44.
09/15/17
HCWC
09/15/17
NO CHANGE
Target $6.5
HCWC
Buy
Capricor Therapeutics price target raised to $6.50 from $2.15 at H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis raised his price target Capricor Therapeutics to $6.50 after increasing his projected chance of success for CAP-1002 in Duchenne muscular dystrophy to 15% from 5%. The analyst sees "significant" FDA visibility for the company's DMD program and believe catalysts next quarter could "reinvigorate interest in the shares." He keeps a Buy rating on Capricor.
01/26/18
HCWC
01/26/18
NO CHANGE
Target $8.6
HCWC
Buy
Capricor Therapeutics price target raised to $8.60 from $6.50 at H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis raised his price target for Capricor Therapeutics to $8.60 following a meeting with management. The analyst increased his projected chance of success for CAP-1002 in Duchenne muscular dystrophy from 15% to 20% and reiterates a Buy rating on the shares.

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