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BMRN

BioMarin

$89.54

1.18 (1.34%)

08:35
05/15/18
05/15
08:35
05/15/18
08:35

BioMarin doses first patient in in a Phase 1/2 study evaluating valoctocogene

BioMarin Pharmaceutical announced that it has dosed the first patient in a Phase 1/2 study evaluating its investigational gene therapy, valoctocogene roxaparvovec, in severe hemophilia A patients with pre-existing AAV5 antibodies. The study is an open-label, single-arm, titer-escalation trial evaluating the safety and efficacy of valoctocogene roxaparvovec in AAV5+ hemophilia A patients. Patients with pre-existing AAV5 antibodies will be sequentially enrolled into two titer cohorts that will encompass the range of observed AAV5 antibody titer levels generally observed in the hemophilia population and be treated with the 6e13 vg/kg dose. The primary endpoint will evaluate safety of valoctocogene roxaparvovec in this population. Secondary endpoints include assessment of FVIII activity level, frequency of required FVIII replacement therapy, and the number of bleeding episodes requiring treatment after therapy.

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BMRN BioMarin
$89.54

1.18 (1.34%)

04/09/18
JEFF
04/09/18
NO CHANGE
JEFF
Jefferies highlights other gene theraphy players after AveXis takeover
Novartis' (NVS) deal to acquire AveXis (AVXS) for $8.7B should remind investors about the ongoing attractiveness within smid-cap biotech, Jefferies analyst Michael Yee tells investors in a research note. Novartis' two large gene therapy deals in four months will lead to a question of "who's next," the analyst adds. Yee says other mid-late stage gene therapy players include Bluebird Bio (BLUE), Spark Therapeutics (ONCE), BioMarin (BMRN), Abeona Therapeutics (ABEO), Regenxbio (RGNX), Nightstar Therapeutics (NITE) and Voyager Therapeutics (VYGR).
04/26/18
JPMS
04/26/18
NO CHANGE
Target $127
JPMS
Overweight
BioMarin optimistic ahead of pegvaliase PDUFA date, says JPMorgan
The most noteworthy takeaway from BioMarin's Q1 update was the company's "very evident optimism" ahead of next month's pegvaliase PDUFA date, JPMorgan analyst Cory Kasimov tells investors in a research note. While the stock has been relatively stagnant for a prolonged period given a perceived lack of catalysts, the potential approval is one of two potential near-term drivers of sentiment leading up to critical Phase 3 readouts in 2019, Kasimov adds. He reiterates an Overweight rating on BioMarin shares with a $127 price target.
04/30/18
BERN
04/30/18
NO CHANGE
Target $92
BERN
Market Perform
BioMarin price target lowered to $92 from $97 at Bernstein
Bernstein analyst Vincent Chen lowered his price target for BioMarin to $92 from $97 following quarterly results. The analyst reiterates a Market Perform rating on the shares.
05/07/18
LEER
05/07/18
NO CHANGE
Target $145
LEER
Outperform
BioMarin price target raised to $145 from $132 at Leerink
Leerink analyst Joseph Schwartz raised his price target to $145 from $132 to reflect new price assumptions for Valrox in hemophilia A following discussions with MEDACorp payor specialists. The analyst reiterates an Outperform rating on the shares.

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APTX

Aptinyx

$24.75

-0.76 (-2.98%)

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OVID

Ovid Therapeutics

$4.75

-0.42 (-8.12%)

21:39
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Ovid Therapeutics initiated at Cantor Fitzgerald »

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AXSM

Axsome Therapeutics

$2.82

-0.07 (-2.42%)

21:38
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Axsome Therapeutics initiated at Cantor Fitzgerald »

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DNLI

Denali Therapeutics

$17.53

0.24 (1.39%)

21:37
11/14/18
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21:37
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21:37
Initiation
Denali Therapeutics initiated at Cantor Fitzgerald »

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OTIC

Otonomy

$2.34

-0.07 (-2.90%)

21:35
11/14/18
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21:35
Initiation
Otonomy initiated at Cantor Fitzgerald »

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AAPL

Apple

$186.81

-5.42 (-2.82%)

20:46
11/14/18
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20:46
Hot Stocks
Apple supplier AMS AG discontinues FY18 targets »

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WEI

Weidai

$0.00

(0.00%)

20:33
11/14/18
11/14
20:33
11/14/18
20:33
Syndicate
Weidai 4.5M share IPO priced at $10.00 »

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CPB

Campbell Soup

$39.16

-0.1 (-0.25%)

20:31
11/14/18
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20:31
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20:31
Hot Stocks
Campbell Soup responds to ISS regarding board elections »

Campbell Soup issued the…

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CRM

Salesforce

$129.25

-2.93 (-2.22%)

20:25
11/14/18
11/14
20:25
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20:25
Periodicals
Breaking Periodicals news story on Salesforce »

Salesforce to accommodate…

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WMT

Walmart

$101.58

-1.37 (-1.33%)

, JCP

J.C. Penney

$1.23

-0.05 (-3.91%)

20:25
11/14/18
11/14
20:25
11/14/18
20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

WMT

Walmart

$101.58

-1.37 (-1.33%)

JCP

J.C. Penney

$1.23

-0.05 (-3.91%)

BERY

Berry Global

$45.91

-0.49 (-1.06%)

03/08/13
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BHVN

Biohaven Pharmaceutical

$33.70

-3.18 (-8.62%)

19:53
11/14/18
11/14
19:53
11/14/18
19:53
Recommendations
Biohaven Pharmaceutical analyst commentary at Piper Jaffray »

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LOXO

Loxo Oncology

$143.69

-15.62 (-9.80%)

19:51
11/14/18
11/14
19:51
11/14/18
19:51
Initiation
Loxo Oncology initiated at Raymond James »

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OCUL

Ocular Therapeutix

$5.06

-0.25 (-4.71%)

19:50
11/14/18
11/14
19:50
11/14/18
19:50
Initiation
Ocular Therapeutix initiated at Raymond James »

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VYGR

Voyager Therapeutics

$11.25

-0.54 (-4.58%)

19:49
11/14/18
11/14
19:49
11/14/18
19:49
Upgrade
Voyager Therapeutics rating change at Raymond James »

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GLPG

Galapagos NV

$103.79

1.03 (1.00%)

19:48
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Initiation
Galapagos NV initiated at Raymond James »

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COPY

CopyTele

$0.00

(0.00%)

19:47
11/14/18
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19:47
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19:47
Upgrade
CopyTele rating change at BMO Capital »

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VICI

VICI Properties

$21.43

-0.04 (-0.19%)

19:40
11/14/18
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19:40
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19:40
Syndicate
VICI Properties 30M share Secondary priced at $21.00 »

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WHD

Cactus

$32.37

-0.7 (-2.12%)

19:37
11/14/18
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19:37
Hot Stocks
Cactus names Stephen Tadlock new CFO »

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RVLT

Revolution Lighting

$1.42

(0.00%)

19:32
11/14/18
11/14
19:32
11/14/18
19:32
Hot Stocks
Revolution Lighting receives revised $1.50 per share proposal from RVL LLC »

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GE

General Electric

$8.34

-0.265 (-3.08%)

19:20
11/14/18
11/14
19:20
11/14/18
19:20
Periodicals
General Electric withdraws from Nigeria rail concession, Reuters says »

GE has withdrawn from a…

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BCSF

Bain Capital Specialty Finance

$0.00

(0.00%)

19:11
11/14/18
11/14
19:11
11/14/18
19:11
Syndicate
Bain Capital Specialty Finance 7.5M share IPO price $20.25 »

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  • 15

    Nov

TSLA

Tesla

$344.07

5.36 (1.58%)

19:07
11/14/18
11/14
19:07
11/14/18
19:07
Periodicals
Tesla Model 3 owners experience issues in cold weather, Electrek says »

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NGHC

National General

$24.75

-3.05 (-10.97%)

19:05
11/14/18
11/14
19:05
11/14/18
19:05
Syndicate
National General 5M share Secondary priced at $24.00 »

JPMorgan, Goldman Sachs…

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