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BMRN

BioMarin

$89.54

1.18 (1.34%)

08:35
05/15/18
05/15
08:35
05/15/18
08:35

BioMarin doses first patient in in a Phase 1/2 study evaluating valoctocogene

BioMarin Pharmaceutical announced that it has dosed the first patient in a Phase 1/2 study evaluating its investigational gene therapy, valoctocogene roxaparvovec, in severe hemophilia A patients with pre-existing AAV5 antibodies. The study is an open-label, single-arm, titer-escalation trial evaluating the safety and efficacy of valoctocogene roxaparvovec in AAV5+ hemophilia A patients. Patients with pre-existing AAV5 antibodies will be sequentially enrolled into two titer cohorts that will encompass the range of observed AAV5 antibody titer levels generally observed in the hemophilia population and be treated with the 6e13 vg/kg dose. The primary endpoint will evaluate safety of valoctocogene roxaparvovec in this population. Secondary endpoints include assessment of FVIII activity level, frequency of required FVIII replacement therapy, and the number of bleeding episodes requiring treatment after therapy.

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BMRN BioMarin
$89.54

1.18 (1.34%)

04/09/18
JEFF
04/09/18
NO CHANGE
JEFF
Jefferies highlights other gene theraphy players after AveXis takeover
Novartis' (NVS) deal to acquire AveXis (AVXS) for $8.7B should remind investors about the ongoing attractiveness within smid-cap biotech, Jefferies analyst Michael Yee tells investors in a research note. Novartis' two large gene therapy deals in four months will lead to a question of "who's next," the analyst adds. Yee says other mid-late stage gene therapy players include Bluebird Bio (BLUE), Spark Therapeutics (ONCE), BioMarin (BMRN), Abeona Therapeutics (ABEO), Regenxbio (RGNX), Nightstar Therapeutics (NITE) and Voyager Therapeutics (VYGR).
04/26/18
JPMS
04/26/18
NO CHANGE
Target $127
JPMS
Overweight
BioMarin optimistic ahead of pegvaliase PDUFA date, says JPMorgan
The most noteworthy takeaway from BioMarin's Q1 update was the company's "very evident optimism" ahead of next month's pegvaliase PDUFA date, JPMorgan analyst Cory Kasimov tells investors in a research note. While the stock has been relatively stagnant for a prolonged period given a perceived lack of catalysts, the potential approval is one of two potential near-term drivers of sentiment leading up to critical Phase 3 readouts in 2019, Kasimov adds. He reiterates an Overweight rating on BioMarin shares with a $127 price target.
04/30/18
BERN
04/30/18
NO CHANGE
Target $92
BERN
Market Perform
BioMarin price target lowered to $92 from $97 at Bernstein
Bernstein analyst Vincent Chen lowered his price target for BioMarin to $92 from $97 following quarterly results. The analyst reiterates a Market Perform rating on the shares.
05/07/18
LEER
05/07/18
NO CHANGE
Target $145
LEER
Outperform
BioMarin price target raised to $145 from $132 at Leerink
Leerink analyst Joseph Schwartz raised his price target to $145 from $132 to reflect new price assumptions for Valrox in hemophilia A following discussions with MEDACorp payor specialists. The analyst reiterates an Outperform rating on the shares.

TODAY'S FREE FLY STORIES

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PSTG

Pure Storage

$22.00

0.2 (0.92%)

15:04
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Options
Pure Storage options imply 10.8% move in share price post-earnings, above median historical move »

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CASY

Casey's General Stores

$116.05

1.33 (1.16%)

15:01
08/21/18
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Conference/Events
Casey's General Stores management to meet with Jefferies »

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RIGL

Rigel Pharmaceuticals

$2.67

0.08 (3.09%)

15:00
08/21/18
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Rigel's Rodriguez says 'work has just begun' with Tavalisse launch »

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EA

Electronic Arts

$127.21

-0.47 (-0.37%)

15:00
08/21/18
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15:00
Options
Electronic Arts attracts a bullish option play »

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URBN

Urban Outfitters

$47.40

-0.12 (-0.25%)

14:49
08/21/18
08/21
14:49
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14:49
Options
Urban Outfitters options imply 12.9% move in share price post-earnings, above median historical move »

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SFIX

Stitch Fix

$34.77

1.92 (5.84%)

14:45
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14:45
Options
Stitch Fix call volume above normal and directionally bullish »

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ATVI

Activision Blizzard

$69.63

0.7 (1.02%)

14:40
08/21/18
08/21
14:40
08/21/18
14:40
Periodicals
Breaking Periodicals news story on Activision Blizzard »

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NURO

NeuroMetrix

$1.26

0.04 (3.28%)

, GSK

GlaxoSmithKline

$41.57

0.25 (0.61%)

14:32
08/21/18
08/21
14:32
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14:32
Hot Stocks
NeuroMetrix receives $3.8M milestone payment under its pact with GSK »

NeuroMetrix (NURO)…

NURO

NeuroMetrix

$1.26

0.04 (3.28%)

GSK

GlaxoSmithKline

$41.57

0.25 (0.61%)

03/08/13
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14:30
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14:30
General news
Canada Retail Sales Preview »

Canada Retail Sales…

14:25
08/21/18
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14:25
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14:25
General news
Treasury Option Action: more bond positioning »

Treasury Option Action:…

MDT

Medtronic

$95.02

4.96 (5.51%)

14:20
08/21/18
08/21
14:20
08/21/18
14:20
Recommendations
Medtronic analyst commentary  »

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MS

Morgan Stanley

$48.75

0.48 (0.99%)

14:20
08/21/18
08/21
14:20
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14:20
Options
Mega option block in Morgan Stanley »

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

14:17
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NASDAQ market internals summary »

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RIGL

Rigel Pharmaceuticals

$2.65

0.06 (2.32%)

14:16
08/21/18
08/21
14:16
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14:16
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Rigel CEO says impact of any Trump policy still unclear »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

14:16
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08/21
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NYSE market internals summary »

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NFLX

Netflix

$339.67

11.92 (3.64%)

, AAPL

Apple

$216.73

1.25 (0.58%)

14:07
08/21/18
08/21
14:07
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14:07
Periodicals
Netflix testing how to bypass iTunes billing in 33 countries, TechCrunch says »

Netflix (NFLX) is…

NFLX

Netflix

$339.67

11.92 (3.64%)

AAPL

Apple

$216.73

1.25 (0.58%)

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  • 21

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UAL

United Continental

$86.00

0.765 (0.90%)

14:06
08/21/18
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14:06
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14:06
Periodicals
United's Kirby sees average airfares improving, Bloomberg reports »

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  • 06

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APO

Apollo Global

$34.44

0.22 (0.64%)

, BX

Blackstone

$36.48

-0.32 (-0.87%)

14:04
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14:04
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14:04
Periodicals
PE firms eyeing acquisitions of local TV assets, CNBC reports »

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APO

Apollo Global

$34.44

0.22 (0.64%)

BX

Blackstone

$36.48

-0.32 (-0.87%)

NXST

Nexstar

$80.25

1.05 (1.33%)

TRCO

Tribune Media

$35.98

0.91 (2.59%)

SBGI

Sinclair Broadcast

$29.30

0.55 (1.91%)

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UAL

United Continental

$86.32

1.085 (1.27%)

14:00
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14:00
Options
Heavy call activity in UAL as shares take off »

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  • 06

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RIGL

Rigel Pharmaceuticals

$2.66

0.07 (2.70%)

13:52
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13:52
Hot Stocks
Rigel's Rodriguez says physician response to Tavalisse 'very positive' »

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JCI

Johnson Controls

$39.84

1.11 (2.87%)

13:50
08/21/18
08/21
13:50
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13:50
Options
Notable call spread in Johnson Controls as shares rally »

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SPY

SPDR S&P 500 ETF Trust

$287.20

1.52 (0.53%)

, SPX

S&P 500

$0.00

(0.00%)

13:46
08/21/18
08/21
13:46
08/21/18
13:46
Periodicals
Michael Cohen enters plea deal with federal prosecutors, ABC News says »

Tom Llamas, ABC…

SPY

SPDR S&P 500 ETF Trust

$287.20

1.52 (0.53%)

SPX

S&P 500

$0.00

(0.00%)

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GME

GameStop

$16.35

0.5 (3.15%)

13:45
08/21/18
08/21
13:45
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13:45
Options
GameStop call volume above normal and directionally bullish »

Bullish option flow…

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13:40
08/21/18
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13:40
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FOMC minutes preview: »

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