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NERV

Minerva

$6.55

-0.1 (-1.50%)

08:03
05/17/18
05/17
08:03
05/17/18
08:03

Minerva announces publication of roluperidone Phase 2B trial results

Minerva Neurosciences announced that The Journal of Clinical Psychiatry has published online results demonstrating cognitive improvements in patients with schizophrenia treated with roluperidone, or MIN-101. The results also demonstrated that cognitive improvements correlate with previously reported improvements in negative symptoms. The manuscript is entitled "Cognitive Effects of MIN-101 in Patients with Schizophrenia and Negative Symptoms: Results from a Randomized Controlled Trial." Roluperidone is a novel compound with affinities for 5HT2A and sigma2 receptors and no direct binding to dopamine receptors. In this regard, roluperidone differs from drugs currently indicated for schizophrenia, all of which directly interfere with dopamine neurotransmission. Results presented in this publication suggest a benefit of roluperidone on cognitive performance in schizophrenia patients with stable positive symptoms and moderate to severe negative symptoms. Researchers hypothesized that because roluperidone lacks the detrimental effects associated with currently available medications that do not benefit cognitive performance in patients with schizophrenia, the potential beneficial effects on cognition induced by 5HT2A antagonism and sigma antagonism would not be disrupted or diminished by other aspects of the compound's mechanism of action.

NERV Minerva
$6.55

-0.1 (-1.50%)

09/01/17
SBSH
09/01/17
INITIATION
Target $11
SBSH
Buy
Minerva Neurosciences initiated with a Buy at Citi
Citi analyst Joel Beatty started Minerva Neurosciences with a Buy rating and $11 price target. The Phase 3 trial for lead agent MIN-101 in negative symptoms of schizophrenia is well positioned for success, Beatty tells investors in a research note. He sees negative symptoms of schizophrenia as an attractive market opportunity because there are no approved drugs for the indication.
09/01/17
09/01/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. DowDuPont (DWDP) initiated with an Outperform at Bernstein. 2. Minerva (NERV) Neurosciences initiated with a Buy at Citi. 3. VMware (VMW) resumed with a Sector Weight at KeyBanc. 4. Provident Financial (PFS) initiated with a Neutral at DA Davidson. 5. Maximus (MMS) initiated with a Neutral at Baird. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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AMZN

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3.73 (0.23%)

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ADSK

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SJM

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DB

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TOT

Total

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IGLD

Internet Gold

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NTNX

Nutanix

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-0.19 (-0.34%)

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TAHO

Tahoe Resources

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-0.195 (-3.68%)

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NKE

Nike

$72.03

0.71 (1.00%)

, UA

Under Armour

$18.34

0.45 (2.52%)

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NKE

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IGLD

Internet Gold

$3.22

0.21 (6.98%)

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Earnings
Internet Gold jumps 20% to $3.65 after disclosing Q1 results 

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IP

International Paper

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$NSD

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$NYE

NYSE Market Internals

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NYSE market internals summary »

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YNDX

Yandex

$33.72

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14:15
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OUT

Outfront Media

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13:50
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ECA

Encana

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PYPL

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SSP

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, DIS

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GM

General Motors

$38.42

0.57 (1.51%)

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  • 20

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ACCO

ACCO Brands

$12.95

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  • 31

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BECN

Beacon Roofing

$41.97

2.18 (5.48%)

13:26
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Conference/Events
Beacon Roofing management to meet with KeyBanc »

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