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NERV

Minerva

$6.55

-0.1 (-1.50%)

08:03
05/17/18
05/17
08:03
05/17/18
08:03

Minerva announces publication of roluperidone Phase 2B trial results

Minerva Neurosciences announced that The Journal of Clinical Psychiatry has published online results demonstrating cognitive improvements in patients with schizophrenia treated with roluperidone, or MIN-101. The results also demonstrated that cognitive improvements correlate with previously reported improvements in negative symptoms. The manuscript is entitled "Cognitive Effects of MIN-101 in Patients with Schizophrenia and Negative Symptoms: Results from a Randomized Controlled Trial." Roluperidone is a novel compound with affinities for 5HT2A and sigma2 receptors and no direct binding to dopamine receptors. In this regard, roluperidone differs from drugs currently indicated for schizophrenia, all of which directly interfere with dopamine neurotransmission. Results presented in this publication suggest a benefit of roluperidone on cognitive performance in schizophrenia patients with stable positive symptoms and moderate to severe negative symptoms. Researchers hypothesized that because roluperidone lacks the detrimental effects associated with currently available medications that do not benefit cognitive performance in patients with schizophrenia, the potential beneficial effects on cognition induced by 5HT2A antagonism and sigma antagonism would not be disrupted or diminished by other aspects of the compound's mechanism of action.

NERV Minerva
$6.55

-0.1 (-1.50%)

09/01/17
SBSH
09/01/17
INITIATION
Target $11
SBSH
Buy
Minerva Neurosciences initiated with a Buy at Citi
Citi analyst Joel Beatty started Minerva Neurosciences with a Buy rating and $11 price target. The Phase 3 trial for lead agent MIN-101 in negative symptoms of schizophrenia is well positioned for success, Beatty tells investors in a research note. He sees negative symptoms of schizophrenia as an attractive market opportunity because there are no approved drugs for the indication.
09/01/17
09/01/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. DowDuPont (DWDP) initiated with an Outperform at Bernstein. 2. Minerva (NERV) Neurosciences initiated with a Buy at Citi. 3. VMware (VMW) resumed with a Sector Weight at KeyBanc. 4. Provident Financial (PFS) initiated with a Neutral at DA Davidson. 5. Maximus (MMS) initiated with a Neutral at Baird. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

DAC

Danaos

$1.60

0.05 (3.23%)

16:52
09/24/18
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Earnings
Danaos reports Q2 EPS 27c, one estimate 23c »

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  • 25

    Sep

AWK

American Water

$87.80

-0.8 (-0.90%)

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American Water to spend $2M to upgrade water main in Missouri »

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  • 29

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COLD

Americold Realty Trust

$25.25

-0.09 (-0.36%)

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PRNB

Principia Biopharma

$27.34

0.24 (0.89%)

16:45
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Breaking Hot Stocks news story on Principia Biopharma »

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DCPH

Deciphera

$39.80

0.78 (2.00%)

16:42
09/24/18
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Initiation
Deciphera initiated  »

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  • 01

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BJ

BJ's Wholesale

$28.47

-0.68 (-2.33%)

16:42
09/24/18
09/24
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Syndicate
BJ's Wholesale files to sell 28M shares of common stock for holders »

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  • 28

    Oct

BPMC

Blueprint Medicines

$71.56

1.8 (2.58%)

16:41
09/24/18
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16:41
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16:41
Initiation
Blueprint Medicines initiated  »

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SGEN

Seattle Genetics

$78.57

0.53 (0.68%)

16:41
09/24/18
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Initiation
Seattle Genetics initiated  »

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LOXO

Loxo Oncology

$163.07

3.91 (2.46%)

16:40
09/24/18
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16:40
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16:40
Initiation
Loxo Oncology initiated  »

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  • 26

    Nov

  • 27

    Nov

INCY

Incyte

$66.48

-0.11 (-0.17%)

16:40
09/24/18
09/24
16:40
09/24/18
16:40
Initiation
Incyte initiated  »

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  • 22

    Oct

AGIO

Agios Pharmaceuticals

$75.39

1.84 (2.50%)

16:40
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Initiation
Agios Pharmaceuticals initiated  »

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SMLR

Semler Scientific

$0.00

(0.00%)

16:40
09/24/18
09/24
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16:40
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Breaking Hot Stocks news story on Semler Scientific »

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CLVS

Clovis

$32.63

0.22 (0.68%)

16:39
09/24/18
09/24
16:39
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16:39
Initiation
Clovis initiated  »

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SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$291.09

-0.94 (-0.32%)

16:39
09/24/18
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16:39
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Periodicals
Trump inks revised trade pact with South Korea, CNBC says »

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SPX

S&P 500

$0.00

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SPY

SPDR S&P 500 ETF Trust

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-0.94 (-0.32%)

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TSRO

Tesaro

$36.41

-1.27 (-3.37%)

16:39
09/24/18
09/24
16:39
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16:39
Initiation
Tesaro initiated  »

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  • 01

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  • 02

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BGNE

BeiGene

$166.12

2.15 (1.31%)

16:38
09/24/18
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16:38
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16:38
Initiation
BeiGene initiated  »

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  • 02

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BW

Babcock & Wilcox

$1.03

0.005 (0.49%)

16:38
09/24/18
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Babcock & Wilcox to relocate Headquarters to Ohio »

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JAGX

Jaguar Health

$0.63

-0.022 (-3.37%)

16:37
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HST

Host Hotels

$20.89

-0.23 (-1.09%)

, VNO

Vornado

$73.52

-1.58 (-2.10%)

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Host Hotels sells New York Marriott Marquis Retail to Vornado for $442M »

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HST

Host Hotels

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VNO

Vornado

$73.52

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  • 25

    Sep

CWEN

Clearway Energy

$19.85

-0.1 (-0.50%)

16:33
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Syndicate
Clearway Energy announces offering of 3.92M shares of Class C common stock »

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KIRK

Kirkland's

$9.30

-0.02 (-0.21%)

16:33
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16:33
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Kirkland's announces new $10M share repurchase program »

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SUM

Summit Materials

$18.76

-0.285 (-1.50%)

16:32
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Summit Materials sells GJP to Ferguson Waterworks, terms not stated »

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KIRK

Kirkland's

$9.30

-0.02 (-0.21%)

16:32
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Kirkland's names Steve Woodward as CEO, Mike Cairnes as COO »

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WRE

Washington REIT

$30.60

-0.32 (-1.03%)

16:32
09/24/18
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Periodicals
Washington REIT explores sale of retail portfolio, Bloomberg reports »

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  • 26

    Oct

SPX

S&P 500

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(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$291.09

-0.94 (-0.32%)

16:31
09/24/18
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Periodicals
Trump says second meeting with Kim Jong Un likely 'quite soon,' AP says »

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S&P 500

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