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NKTR

Nektar

$53.91

0.45 (0.84%)

10:02
06/14/18
06/14
10:02
06/14/18
10:02

Nektar presents NKTR-181 data showing 'consistently low abuse potential'

Nektar Therapeutics announced that new clinical and preclinical data for NKTR-181 were presented this week at the 80th Annual Scientific Meeting of the College on Problems of Drug Dependence in San Diego, California. NKTR-181 is a new molecular entity and the first analgesic opioid molecule to exhibit a reduced incidence of specific CNS-mediated side effects, such as euphoria, through the targeted alteration of brain-entry kinetics. "We are privileged that these meaningful new data from our clinical trials, as well as our translational research, were recognized for oral presentation at the prestigious CPDD meeting," said Steve Doberstein, Ph.D., SVP and Chief Research and Development Officer of Nektar Therapeutics. "The data presented show that NKTR-181 demonstrates consistently low abuse potential when we look at a range of measurements used to understand potential abuse liability of investigational medicines including the MADDERS assessment. In addition, we demonstrated in our preclinical research that NKTR-181 has a unique neuropharmacodynamic profile with slow brain uptake and a blunted dopamine response as compared to oxycodone." Nektar recently submitted a New Drug Application for NKTR-181 for the treatment of chronic low back pain in adult patients new to opioid therapy. The NDA is supported by an extensive clinical and nonclinical data package. The clinical data submitted in the NDA comprised 15 studies in 2,234 subjects and includes: a 600-patient efficacy study in patients with chronic low back pain who are new to opioid therapy; a 630-patient long-term 52-week safety study in patients with noncancer pain, who are new to opioid therapy, as well as those who are experienced with opioid therapy; pharmacokinetic/pharmacodynamic studies in over 450 subjects; and two human abuse potential studies evaluating both therapeutic and supratherapeutic doses of NKTR-181 versus an oxycodone control in recreational drug users.

NKTR Nektar
$53.91

0.45 (0.84%)

06/11/18
06/11/18
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. SemGroup (SEMG) downgraded to Market Perform from Outperform at Wells Fargo with analyst Michael Blum saying he believes its growth trajectory is mostly reflected in valuation. 2. Host Hotels (HST) and Park Hotels (PK) were downgraded to Sell from Neutral at Goldman Sachs, Host Hotels was also downgraded to In Line from Outperform at Evercore ISI. 3. NXP Semiconductors (NXPI) downgraded to Hold from Buy at SunTrust with analyst William Stein saying the current stock price is above fair value and demands "an explicit view" that the Qualcomm (QCOM) bid will receive approval from China regulators. 4. Nektar (NKTR) downgraded to Neutral from Buy at H.C. Wainwright with analyst Debjit Chattopadhyay saying an updated cut of NKTR-214 data presented at an investor conference on June 06, does not assuage fears on the outlook of NKTR-214 in the post ECHO-301, immuno-oncology combination therapy landscape. 5. DDR Corp. (DDR) downgraded to Underperform from In Line at Evercore ISI. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
06/11/18
HCWC
06/11/18
DOWNGRADE
Target $54
HCWC
Neutral
Nektar downgraded to Neutral from Buy at H.C. Wainwright
H.C. Wainwright analyst Debjit Chattopadhyay downgraded Nektar Therapeutics to Neutral and cut his price target for the shares to $54 from $97. The stock closed Friday up $1.17 to $54.14. An updated cut of NKTR-214 data presented at an investor conference on June 06, does not assuage fears on the outlook of NKTR-214 in the post ECHO-301, immuno-oncology combination therapy landscape, Chattopadhyay tells investors in a research note. This has been "further punctured by the lack of meaningful updates" in non-small-cell lung carcinoma, the primary driver of NKTR-214's valuation in an environment where competition is better positioned, the analyst contends. Chattopadhyay now has a "less than sanguine read of the emerging data" from Nektar.
06/05/18
ADAM
06/05/18
NO CHANGE
Target $94
ADAM
Buy
Nektar data suggests it could play pivotal role in cancer, says Canaccord
Canaccord analyst Arlinda Lee said data for Nektar's NKTR-214+Opdivo continues to show promise and she believes it is indicative of having a central role in cancer therapy with its broad mechanism of expanding and activating T-effector cells and efficacy. She reiterated her Buy rating and $94 price target on Nektar shares, which fell nearly 42% to $52.57 yesterday.
06/04/18
WBLR
06/04/18
NO CHANGE
WBLR
Outperform
William Blair optimism on NKTR-214 remains unchanged
William Blair analyst Andy Hsieh says his long-term optimism on Nektar Therapeutics' NKTR-214 remains unchanged following this weekend's update. Given the recent epacadostat setback, there has been increasing scrutiny around data generated from single-arm uncontrolled studies from both the medical and investment communities, Hsieh tells investors in a research note. The analyst thinks the new data will not quell the bearish views on NKTR-21 and that investor confusion about the Fleming analysis could further add volatility to today's trading session. He believes the true potential of NKTR-214 might not be fully realized until later this year and keeps an Outperform rating on Nektar.

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TOT

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Equinor

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CVX

Chevron

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COP

ConocoPhillips

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BP

BP

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Washington REIT

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Apple

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AMZN

Amazon.com

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JBGS

JBG Smith Properties

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1.34 (0.61%)

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ARNC

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ENLK

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HLX

Helix Energy

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HLX

Helix Energy

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UAL

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Intelsat

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CDNS

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SS&C

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BRO

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DIS

Disney

$118.22

-0.59 (-0.50%)

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HSBC

HSBC

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WSFS

WSFS Financial

$43.08

-0.46 (-1.06%)

18:49
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IQV

Iqvia

$126.36

-0.52 (-0.41%)

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$142.92

2.47 (1.76%)

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Iqvia

$126.36

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Salesforce

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BK

BNY Mellon

$46.47

-0.94 (-1.98%)

18:20
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CLGX

CoreLogic

$45.36

-0.01 (-0.02%)

18:07
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ABBV

AbbVie

$84.27

-3.74 (-4.25%)

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